The Effects of Quercetin on Apoptosis and Antioxidant Activity in a Renal Ischemia/Reperfusion Injury Animal Model

Bagheri, Amin; Radman, Ghazal; Aria, Negar; Rezaei, Fatemeh; Khajenouri, Mohammad; Ghiabi, Shamim; Bagheri, Yasin

doi:10.1055/a-1999-7600

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…Quercetin, which also has potent antioxidant and anti-inflammatory actions [15], may enhance aerobic exercise performance [16] and power output during sprint exercise when administered together with Zynamite ® [4,5]. Animal and cell culture experiments have shown that both mangiferin [13,[17][18][19] and quercetin exert protection against damage caused by ischemia-reperfusion [20][21][22][23], which could, in part, be explained by their inhibitory effects on XO and NOX [24,25].…”

Section: Introductionmentioning

confidence: 99%

A Mango Leaf Extract (Zynamite®) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle

Martinez-Canton,

Galvan-Alvarez,

Garcia-Gonzalez

et al. 2023

Nutrients

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Zynamite PX®, a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite® + 140 mg quercetin/8 h for 2 days). Then, they performed incremental exercise to exhaustion (IE) followed by occlusion of the circulation in one leg for 60 s. Afterwards, the cuff was released, and a 30 s sprint was performed, followed by 90 s circulatory occlusion (same leg). Vastus lateralis muscle biopsies were obtained at baseline, 20 s after IE (occluded leg) and 10 s after Wingate (occluded leg), and bilaterally at 90 s and 30 min post exercise. Compared to the controls, the Zynamite PX® group showed increased basal protein expression of Thr287-CaMKIIδD (2-fold, p = 0.007) and Ser9-GSK3β (1.3-fold, p = 0.005) and a non-significant increase of total NRF2 (1.7-fold, p = 0.099) and Ser40-NRF2 (1.2-fold, p = 0.061). In the controls, there was upregulation with exercise and recovery of total NRF2, catalase, glutathione reductase, and Thr287-CaMKIIδD (1.2–2.9-fold, all p < 0.05), which was not observed in the Zynamite PX® group. In conclusion, Zynamite PX® elicits muscle signaling changes in resting skeletal muscle resembling those described for exercise training and partly abrogates the stress kinases responses to exercise as observed in trained muscles.

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