The effects of pulsatile and nonpulsatile systemic perfusion on renal sympathetic nerve activity in anesthetized dogs

Fukae, Kouji; Tominaga, Ryuji; Tokunaga, Shigehiko; Kawachi, Yoshito; Imaizumi, Tsutomu; Yasui, Hirofumi

doi:10.1016/s0022-5223(96)70459-2

Cited by 71 publications

(45 citation statements)

References 19 publications

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“…In previous studies the urine output value is used as an indicator for renal function -this has been shown to be the case by Urzua et al [25] and Badner et al [26] who reported a direct relationship of both urine output and glomerular fi ltration rate with systemic perfusion pressure. This may also explain the failure of urine output during cardiopulmonary bypass to predict postoperative renal function [27]. Colloid transfusion and urine output are shown in fi gure 1 .…”

Section: Resultsmentioning

confidence: 99%

Pulsatile Flow Improves Renal Function in High-Risk Cardiac Operations

Kocakulak

Aşkın²,

Küçükaksu³

et al. 2005

Blood Purif

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The effects of pulsatile perfusion on microcirculation and renal function in high-risk patients were evaluated in this study. Pulsatile roller pumps with a pulsatile control module and membrane oxygenator were used in a clinical setting. 40 patients undergoing elective cardiac surgery with a high risk of either having chronically obstructive pulmonary disease or chronic renal failure were randomly included in the study to be perfused using pulsatile or continuous flows. Blood samples were collected at induction of anesthesia, at the time of aortic clamping and declamping and 1 and 24 h following cessation of the bypass. Urea and creatinine concentrations in blood were measured and systemic vascular resistance was calculated. Urine output, crystalloid and colloid infusions were recorded. We observed that pulsatile roller pump perfusion and the extracorporeal circuit used in the clinical study improved microcirculation and renal function in high-risk patients undergoing cardiopulmonary bypass.

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Section: Resultsmentioning

confidence: 99%

Pulsatile Flow Improves Renal Function in High-Risk Cardiac Operations

Kocakulak

Aşkın²,

Küçükaksu³

et al. 2005

Blood Purif

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“…Already in 1972 Calne et al [34] described a squirt liver perfusion of porcine liver and showed superior results when the perfusate was administered intermittently at higher pressures as a squirt of a bolus of perfusate. Studies of kidney preservation also suggested better organ function and microcirculation by using a pulsatile rather than a nonpulsatile perfusion technique [35,36].…”

Section: Discussionmentioning

confidence: 99%

Hypothermic Oscillating Liver Perfusion Stimulates ATP Synthesis prior to Transplantation

Dutkowski¹,

Odermatt²,

Heinrich³

et al. 1998

Journal of Surgical Research

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“…Additionally, CPB patients have a higher risk of stroke (5,6). There are many possible reasons for those phenomena, such as embolism (7,8) caused by the cannula jet hitting the aortic wall (9)(10)(11), or manipulation of the aorta by cannulae or clamps (12)(13)(14). Different cannulae have been developed to improve the cerebral perfusion during CPB (15,16).…”

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confidence: 99%

The Impact of Aortic/Subclavian Outflow Cannulation for Cardiopulmonary Bypass and Cardiac Support: A Computational Fluid Dynamics Study

Kaufmann¹,

Hormes²,

Laumen³

et al. 2009

Artificial Organs

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Approximately 100 000 cases of oxygen deficiency in the brain occur during cardiopulmonary bypass (CPB) procedures each year. In particular, perfusion of the carotid and vertebral arteries is affected. The position of the outflow cannula influences the blood flow to the cardiovascular system and thus end organ perfusion. Traditionally, the cannula returns blood into the ascending aorta. But some surgeons prefer cannulation to the right subclavian artery. A computational fluid dynamics study was initially undertaken for both approaches. The vessel model was created from real computed tomography/magnetic resonance imaging data of young healthy patients. The simulations were run with usual CPB conditions. The flow distribution for different cannula positions in the aorta was studied, as well as the impact of the cannula tip distance to vertebral artery for the subclavian position. The study presents a fast method of analyzing the flow distribution in the cardiovascular system, and can be adapted for other applications such as ventricular assist device support. It revealed that two effects cause the loss of perfusion seen clinically: a vortex under the brachiocephalic trunk and low pressure regions near the cannula jet. The results suggest that cannulation to the subclavian artery is preferred if the cannula tip is sufficiently far away from the branch of the vertebral artery. For the aortic positions, however, the cannula should be injected from the left body side.

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The effects of pulsatile and nonpulsatile systemic perfusion on renal sympathetic nerve activity in anesthetized dogs

Cited by 71 publications

References 19 publications

Pulsatile Flow Improves Renal Function in High-Risk Cardiac Operations

Pulsatile Flow Improves Renal Function in High-Risk Cardiac Operations

Hypothermic Oscillating Liver Perfusion Stimulates ATP Synthesis prior to Transplantation

The Impact of Aortic/Subclavian Outflow Cannulation for Cardiopulmonary Bypass and Cardiac Support: A Computational Fluid Dynamics Study

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