The effects of protein malnutrition and experimental infection with Trypanosoma brucei on gossypol treatment in the rat: Haematological and serum biochemical changes

Akingbemi, B. T.; Ogwuegbu, S. O.; Onwuka, SK; Oke, B. O.; Aire, Tom A.

doi:10.1016/s0021-9975(05)80017-9

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…In addition, plasma HDL-C and LDL-C levels in the gossypol-treated group were significantly increased and decreased, respectively, together with numerically lowered plasma TC, TG, and milk fat contents, indicating a reduction in peripheral lipid metabolism and enhanced hepatic lipid accumulation, which is in line with previous studies. − A study of adult male cynomolgus monkeys found that gossypol, administered orally at 10 mg/kg/day for 6 months, caused a significant decrease in total plasma cholesterol and LDL . Studies in rabbits have also shown that dietary cottonseed protein effectively lowers the concentration of plasma cholesterol when compared with the animal protein casein, which may be attributed to the presence of gossypol in the cottonseed protein .…”

Section: Discussionsupporting

confidence: 85%

“…Studies in rabbits have also shown that dietary cottonseed protein effectively lowers the concentration of plasma cholesterol when compared with the animal protein casein, which may be attributed to the presence of gossypol in the cottonseed protein . Thrice-weekly subcutaneous gossypol injections of 20 mg/kg body weight to rats for 4 weeks also resulted in lower serum cholesterol . Another study in rats demonstrated that gossypol consumption had a significant effect on alcohol dehydrogenase and had a profound influence on the regulation of hepatic cholesterol levels .…”

Section: Discussionmentioning

confidence: 99%

“…26 Thrice-weekly subcutaneous gossypol injections of 20 mg/kg body weight to rats for 4 weeks also resulted in lower serum cholesterol. 25 Another study in rats demonstrated that gossypol consumption had a significant effect on alcohol dehydrogenase and had a profound influence on the regulation of hepatic cholesterol levels. 24 A subsequent study in rats showed that the administration of gossypol at 20 mg/kg body weight/rat/day for 8 weeks significantly decreased serum cholesterol levels.…”

Section: ■ Discussionmentioning

confidence: 99%

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Metabolic Characterization of Dairy Cows Treated with Gossypol by Blood Biochemistry and Body Fluid Untargeted Metabolome Analyses

Tang

Zhang

Zhan

et al. 2017

J. Agric. Food Chem.

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To characterize the metabolic disorders of dairy cows treated with gossypol, 12 dairy cows were assigned to either a control group or a treatment group that was fed 1000 mg of gossypol per kilogram of dry matter feed for 28 days. Milk quality was adversely affected, as both milk protein and lactose levels were significantly decreased in the gossypol-treated group (3.40% vs 3.16%, P = 0.044; 5.15% vs 4.91%, P = 0.027; respectively). Plasma samples revealed increases in alanine aminotransferase (P = 0.092), choline esterase (P = 0.02), and glutathione transferase (P = 0.0005) and decreases in glucose (P = 0.076) in the gossypol-treated group. Mass spectrometry based comparative metabolomic analyses showed reduced concentrations of the gluconeogenesis precursor l-glutamine (P = 0.047), with significant decreases (P < 0.05) in plasma l-lysine, l-threonine, and homoserine levels after gossypol treatment. HDL-C and LDL-C levels in the gossypol-treated group were increased (P = 0.044) and decreased (P = 0.023), respectively. These results demonstrate that gossypol induced oxidative stress and hepatotoxicity; reduced peripheral lipid metabolism, and enhanced hepatic lipid accumulation; decreased amino acid bioavailability and milk protein synthesis; and decreased gluconeogenesis and milk lactose in dairy cows.

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