The effects of prostaglandins E1, A1, and F2a on the cerebral circulation of dogs and monkeys

Abstract

✓ Alterations in cerebrovascular tone caused by the intracarotid administration of prostaglandin E1, A1, and F2a were evaluated by means of a standard perfusion technique in dogs and monkeys. Only PGF2a evoked a selective increase in cerebrovascular tone. This effect was observed in both species and resembled the action of serotonin. On the other hand, prostaglandin E1 selectively reduced cerebrovascular tone in dogs, but had no such specific action in the monkey. Prostaglandin A1 lacked a specific influence on the cerebral circulation of either species. Since different prostaglandins produced specific and diametrically opposite effects on cerebral circulation, these substances may be useful in experimental studies of vasospasm, and may normally influence cerebrovascular tone.

Role of Prostaglandins and Arachidonic Acid Derivatives in the Coupling of Cerebral Blood Flow to Cerebral Metabolism

“…Only in those investigations where there is the possibility of extracranial contamination has the suggestion been made that PGE! or PGE2 might be vasodilatory (Denton et al , 1972;Pelofsky et aI. , 1972;Nakano et aI.…”

Brain Prostaglandins E₂ and F_2α following Neonatal Asphyxia in the Guinea Pig

“…Several of the prostaglandins are potent vasoactive sub stances, capable of either dilating or con stricting vessels [4,6,8,15,20,21,25,26]. Levels of prostaglandins increase in the cere brospinal fluid following a variety of insults to the adult brain such as stroke, hemorrhage, and trauma [3,7,13], and it has been sug gested that the increased levels of vasocon strictor prostaglandins in the brain may lead to cerebral artery constriction, thereby re stricting blood flow and enhancing the extent of brain damage in these conditions.…”

The effect of latanoprost on ocular blood flow

“…PGF 2a has been shown to induce both the constriction and relaxation of smooth muscle in different studies [17][18][19]. The administration of PGF 2a induced a selective increase in cerebral vascular tone in canine and monkey models, while causing smooth muscle relaxation in the canine uterine artery [17][18][19].…”

“…Based on physiologic data and dependent on the concentration and the exposed vascular bed, prostaglandin F 2a (PGF 2a ) may have a variety of vascular effects [16]. Studies have shown that in animal models PGF 2a causes relaxation and constriction in different vascular beds [17][18][19].…”