The effect of latanoprost on ocular blood flow

Harris, Alon; Garzozi, Hanna J.; McCranor, L.; Rechtman, Ehud; Yung, Chi Wah; Siesky, Brent

doi:10.1007/s10792-008-9190-x

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…The published effects of latanoprost on OBF are also heterogeneous. Whereas some authors have found a neutral effect on OBF in healthy subjects33 and in patients with primary open-angle glaucoma,28,34–37 others have described an increase of OBF in heathy volunteers38 and in patients with primary open-angle glaucoma 33,39. In ex vivo studies, latanoprost reduced the endothelin-induced vasoconstriction of isolated rabbit ciliary arteries40 and in in vivo studies with rabbits, latanoprost mitigated the endothelin-induced reduction of optic nerve head blood flow 40.…”

Section: Discussionmentioning

confidence: 85%

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Konieczka

Koch

Hauenstein

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose The aim of this study was to investigate the effects of the glaucoma drugs latanoprost, brimonidine, and the combination of both on the central corneal temperature (CT) of healthy subjects by means of infrared thermography. Changes of the central CT may reflect changes of ocular blood flow. Methods Before application and during 2 hours after the application of latanoprost, brimonidine, or the combination of both in one eye, the CT in both eyes of 40 healthy subjects was measured repeatedly. Results Brimonidine reduced CT by approximately 0.5°C. This effect was statistically significant ( P < 0.0001). Latanoprost, however, had a very small and insignificant influence ( P = 0.47). Accordingly, the combination of brimonidine and latanoprost also reduced CT up to 0.5°C, and this effect was statistically significant ( P < 0.0001). Conclusions Brimonidine, but not latanoprost, had a significant effect on central CT. This cooling effect of brimonidine is most probably due to a drug-induced reduction of blood circulation in the ciliary body and iris and to a certain extent also to a reduction of blood flow in the fundus of the eye. Translational Relevance This study shows evidence that thermography of the cornea provides indirect information on the influence of drugs on the blood flow to the anterior segment of the patient's eye.

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Section: Discussionmentioning

confidence: 85%

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Konieczka

Koch

Hauenstein

et al. 2019

Trans. Vis. Sci. Tech.

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“…We believe that the effect of PG analogs on ocular blood flow may be limited. Some other studies reported that there was no significant change in ocular circulation after the instillation of latanoprost [38–40]. Akaishi et al reported that the increase in the ONH blood flow induced by tafluprost was greater than that induced by latanoprost [11].…”

Section: Discussionmentioning

confidence: 99%

Pulse Waveform Analysis of the Ocular Blood Flow Using Laser Speckle Flowgraphy before and after Glaucoma Treatment

Masai

Ishida

Anraku

et al. 2019

Journal of Ophthalmology

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Although reduction in intraocular pressure (IOP) is the principle of glaucoma treatment, impaired ocular blood flow is believed to play a role in the progression of glaucoma. This study evaluated the effect of glaucoma treatment on pulse waveforms for optic nerve head (ONH) microcirculation in patients with glaucoma. Fifty-one subjects were included on the basis of the glaucoma treatment administered, which involved instillation of prostaglandin (PG) analogs (PG group; n = 28) or trabeculectomy (trabeculectomy group; n = 23). ONH blood flow, represented by the mean blur rate (MBRT) and pulse waveforms, was measured using laser speckle flowgraphy before and 1 and 3 months after treatment. Three months after treatment, IOP exhibited a significant decrease (p < 0.05). Although there was no significant change in MBRT after treatment, the acceleration time index (ATI) significantly decreased (p=0.034) in the PG group. In the trabeculectomy group, there was no significant change in the MBRT after treatment, while fluctuation (p=0.019) and blowout score (BOS) (p=0.036) exhibited significant decrease and increase, respectively. Multiple regression analysis showed that mean deviation was significantly associated with the rate of change in the BOS (p=0.013), age was a significant contributing factor for the rate of change in fluctuation in the trabeculectomy group, reflection was significantly associated with the ATI (p=0.037) in the in the PG group. Both glaucoma treatments can change the pulse waveforms, with MBRT remaining unchanged, and IOP reduction owing to the treatment may contribute to stable blood flow in the tissue area of the ONH. As impaired ocular blood flow plays a role in the progression of glaucomatous damage, it would be beneficial if glaucoma treatment could improve the stability of ONH microcirculation.

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“…Some studies showed a decrease in ocular blood flow during treatment with prostaglandin analogues. In a study on 12 healthy subjects receiving either latanoprost or placebo, there was no change in the retrobulbar blood flow velocity as measured by CDI, but there was a slight decrease in the retinal microcirculation as measured in the 10th and 25th percentile of the supero‐temporal region of the Heidelberg retina flowmeter (HRF) (Harris et al. 2009).…”

Section: Drug Treatment and Gas Perturbation Influencing Blood Flow Amentioning

confidence: 99%

Contrast sensitivity, ocular blood flow and their potential role in assessing ischaemic retinal disease

Shoshani¹,

Harris²,

Rusia³

et al. 2011

Acta Ophthalmologica

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ABSTRACT.Purpose: To examine the definition, evaluation methodology, association to ocular blood flow and potential clinical value of contrast sensitivity (CS) testing in clinical and research settings, focusing in patients with ischemic retinal disease. Methods: A review of the medical literature focusing on CS and ocular blood flow in ischemic retinal disease. Results: CS may be more sensitive than other methods at detecting subtle defects or improvements in primarily central retinal ganglion cell function early on in a disease process. CS testing attempts to provide spatial detection differences which are not directly assessed with standard visual acuity chart testing. Analyzing all studies that have assessed both CS change and ocular blood flow, it is apparent that both choroidal circulation and retinal circulation may have an important role in influencing CS. Conclusion: The concept that CS is directly influenced by ocular blood flow is supported by reviewing the studies involving both. Although the studies in the literature have not established a direct cause and effect relationship per se, the literature review makes it logical to assume that changes in retinal and choroidal blood flow influence CS. This raises the possibility that a subjective visual characteristic, specifically CS, may be able to be evaluated more objectively by studying blood flow. It appears appropriate to study the relationship between blood flow and CS more extensively to develop improved ways of measuring various aspects of blood flow to the eye and to best quantify early changes in visual function.

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The effect of latanoprost on ocular blood flow

Abstract: Latanoprost has mostly neutral effects on ocular circulation. These findings must be investigated in glaucoma patients who may respond differently than healthy subjects due to faulty vascular autoregulation.

Cited by 15 publications

References 34 publications

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Pulse Waveform Analysis of the Ocular Blood Flow Using Laser Speckle Flowgraphy before and after Glaucoma Treatment

Contrast sensitivity, ocular blood flow and their potential role in assessing ischaemic retinal disease

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