The Effects of Prolonging the Life of the Corpus Luteum in the Rabbit by Hysterectomy

Asdell, S. A.; Hammond, J. E.

doi:10.1152/ajplegacy.1933.103.3.600

Cited by 43 publications

(13 citation statements)

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“…Animals in which the presence of the uterus is important for cyclic ovarian activity include the cow (Wiltbank & Casida, 1956), sheep (Wiltbank & Casida, 1956), pig (du Mesnil du Buisson & Dauzier, 1959) and guinea-pig (Loeb, 1923). In the mouse (Bartke, 1970), rat (Bradbury, Brown & Gray, 1950), hamster (Caldwell, Mazer & Wright, 1967) and rabbit (Asdell & Hammond, 1933), hysterectomy does not affect cyclic ovarian function but does result in prolongation of the pseudopregnant state. Recently,344 G. H. Stabenfeldt et al evidence has been presented that hysterectomy prolongs the life span of the CL in the non-pregnant mare (Ginther & First, 1971).…”

Section: Introductionmentioning

confidence: 99%

The Role of the Uterus in Ovarian Control in the Mare

Stabenfeldt¹,

Jp²,

Wheat³

et al. 1974

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The effect of hysterectomy on ovarian activity was studied in four mares. The cyclic secretion pattern of plasma progestins normally observed in the intact mare was interrupted by hysterectomy. Follicular activity was observed in all four hysterectomized mares, in spite of prolonged luteal activity, with a large number of follicles attaining ovulatory size without the occurrence of ovulation. Some ovulations were observed at irregular intervals in two out of four hysterectomized mares in spite of plasma progestin levels which ranged from 2 to 6 ng/ml. While all ovulations which occurred in the hysterectomized mares were followed by the formation of CL as determined by palpation per rectum, the rise of progestins in the peripheral plasma was variable as significant increases followed CL formation in some instances but not in others. Four mares had CL with functional life spans of 48, 74, 75 and 77 days at the time the experiment was terminated. There was no difference in the ability of the CL formed following these ovulations to convert pregnenolone to progesterone (per unit weight) as compared to CL of 9 days duration. The longest estimated CL life span in any hysterectomized mare was 137 days. Sexual receptivity did not occur in conjunction with follicular growth and ovulation in the hysterectomized mares in the presence of an active CL.

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Section: Introductionmentioning

confidence: 99%

The Role of the Uterus in Ovarian Control in the Mare

Stabenfeldt¹,

Jp²,

Wheat³

et al. 1974

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“…Hysterec¬ tomy also prolongs the life span of pseudopregnancy corpora lutea in rats (Brad¬ bury, Brown & Gray, 1950;Perry & Rowlands, 1961) and rabbits (Asdell & Hammond, 1933). Of the possible uterine factors which might terminate luteal function, a luteolytic uterine factor has been postulated most frequently.…”

Section: Introductionmentioning

confidence: 99%

Effect of Bovine Endometrial Extracts, Vasopressin and Oxytocin on the Duration of Pseudopregnancy in Hysterectomized and Intact Rats

Malven¹,

Hansel²

1965

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Hysterectomy of pseudopregnant rats consistently increased the duration of vaginal dioestrus and the interval between ovulations. These observations suggested that the presence of the nongravid rat uterus limits the life span of pseudopregnancy corpora lutea.Neither aqueous nor ether extracts of bovine endometrium collected at several stages of corpus luteum function significantly affected the life span of corpora lutea in hysterectomized pseudopregnant rats.Vasopressin decreased the duration of vaginal dioestrus and hastened ovulation in hysterectomized, but not in intact, pseudopregnant rats, suggesting that it hastened luteal regression after hysterectomy.Oxytocin failed to shorten the period of luteal function in the hysterectomized rat. Ovarian weight in intact and hysterectomized rats was increased by this means.

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“…Total hysterectomy in the rabbit extends the life of the CL (Asdell & Hammond, 1933) and exogenous prostaglandins cause luteolysis (Duncan & Pharriss, 1970). Few detailed studies have been reported on the vasculature of the rabbit ovary and the present investigation was carried out to determine whether anatomical prerequisites exist for a local uterine control of luteal function.…”

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confidence: 99%