Angiographic Studies of the Extrinsic Vasculature of the Rabbit Ovary

Janson, Per Olof; Svendsen, P.

doi:10.1530/jrf.0.0420175

Cited by 9 publications

(11 citation statements)

References 10 publications

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“…This, in turn, is in agreement with ovservations made during angiography of the intact reproductive tract in rabbits (Janson & Svendsen 1975). In those experiments a greater filling with contrast material occurred in tubai vessels adjacent to a follicular ovary while no vessels were visible next to a luteal ovary with a high rate of blood flow.…”

Section: Direct Blood Flow Measurementssupporting

confidence: 88%

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

Janson¹,

Williams²,

Petrucco³

et al. 1983

Acta Endocrinologica

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Blood flow to the ovary, vascular pedicle and oviduct was measured in anaesthetized non-cycling and cycling ewes by timed collection of ovarian venous blood. The degree of arterio-venous shunting across the ovary and pedicle was estimated both in vivo and in vitro by perfusing the tissues with 15 \m=+-\5 \g=m\mradioactive micro\x=req-\ spheres.The mean ovarian blood flow in non-cycling animals was 1.9 ml/min, which was 51% of blood flow in the ovarian vein. In cycling animals ovarian blood flow at midcycle was 2.9 ml/min (66% of ovarian venous flow) in non\x=req-\ luteal ovaries and 4.3 ml/min (79% of venous flow) in luteal ovaries. The degree of arterio-venous shunting was low in all stages of the cycle (1.0\p=n-\2.6% across ovary + pedicle). The degree of shunting was also found to be very small in vitro (0.007\p=n-\1.38%) in both non-luteal and luteal ovaries. A considerable number of microspheres was entrapped in the vascular pedicle of the ovary indicating the presence of an extensive capillary bed. There was an inverse relationship between blood flow in the ovary and flow in the vascular pedicle.Alterations in distribution of blood flow between the ovary and adjacent structures supplied by the ovarian artery may be of functional significance in allowing rapid changes in ovarian blood flow. The results of the present study indicate that changes in ovarian blood flow during the oestrous cycle are not caused by an action on arteriovenous shunt vessels.In the search for mechanisms underlying the uter¬ ine control of corpus luteum (CL) function of the ewe, much attention has been paid to the structure of ovarian blood vessels and the rates of blood flow

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Section: Direct Blood Flow Measurementssupporting

confidence: 88%

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

Janson¹,

Williams²,

Petrucco³

et al. 1983

Acta Endocrinologica

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“…In the past, 3D studies of ovarian vascularization were performed by light microscopic observations of serial sections of dye-injected samples [9][10][11][12], followed by graphic reconstruction and drawings. Angiography [13,14], diaphanoscopy [15,16] and microangiography of sectioned ovaries [15,17] have also been usefully applied to the study of the anatomy and topography of the ovarian vessels. In addition, direct observation of corroded or clarified vascular casts, after injection of colored latex [18,19], Micropaque ® [20], vinylite [21,24] or other plastic compounds [14] into the ovarian artery of various mammals including humans revealed fine details of vasculature.…”

Section: Historical Backgroundmentioning

confidence: 99%

The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

Macchiarelli

2000

Journal of Reproduction and Development

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Abstract. The vascular changes of the ovary were studied by scanning electron microscopy of vascular corrosion casts in estrous, pseudopregnant (stimulated with human chorionic gonadotropin -hCG) and pregnant rabbits. The results demonstrated that ovarian cycle and pregnancy may induce both structural and functional changes in the ovarian vessels. In fact the ovarian blood vessels adapted their structure to the temporary functional needs of the recruited follicles or corpora lutea. These changes involved both larger ovarian blood vessels (supplying the hilus and the medulla) and cortical blood vessels (supplying the luteo-follicular complexes). Hilar and medullary blood vessels also displayed morphological devices for the continuous control of the blood flow (spiral arteries) and for the local recirculation of endocrine products (artero-venous contacts). Such contacts, may likely sustain a "countercurrent mechanism" which was also shown in ovaries of other species. Scanning electron microscopy of vascular corrosion casts even demonstrated that cortical blood vessels are subjected to continuous remodeling. SEM showed different morphological types of vascular plexuses which supplied antral follicles (Types 1-2), atretic follicles (Types 3-4), peri-ovulatory follicles (Type 5), growing pseudopregnant corpora lutea (Type 6) regressing pseudopregnant corpora lutea (Type 7) and pregnant corpora lutea (Type 8). In estrous rabbit, growing to mature follicles (Types 1-2) showed a gradual enlargement and proliferation of the theca capillaries. These changes, associated with capillary hyperpermeabilization were observed in ovulatory and post-ovulatory follicles (Type 5), after hCG stimulation. The corpus luteum formation (Type 6 and 8) was accompanied by additional capillary dilation, diffuse angiogenetic sprouting and organization of conspicuous venous drainage which appeared more enhanced in pregnant (type 8) than in pseudopregnant (type 6) corpora lutea. The regression of the corpus luteum (Type 7) was characterized by the appearance of avascular areas within the gland and by regression of vascular dilatation. Finally, in estrous rabbit the atretic follicles (Types 3-4) wall showed large interruptions (avascular areas) and focal invasion of the central cavity by newly formed capillaries arranged randomly. The hCG stimulation did not affect consistently the interstitial microvasculature. It is concluded that the gradual increase of ovarian blood flow occuring during follicle growth and corpora lutea formation is provided by a functional adaptation of major ovarian vessels and by capillary functional (vasodilation) and structural (angiogenesis) support as well. Key words: Ovary, Blood vessels, Capillary, Corrosion casts, Angiogenesis, Scanning electron microscopy, Rabbit.(J. Reprod. Dev. 46: [207][208][209][210][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225] 2000) ndocrine and ovulatory activities of the ovary have strict and continuous relationship with -Reviewblood vessels changes. In fact...

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“…Angiography (Janson and Svendsen 1975;Bendz et al 1982), diaphanoscopy (Rodrigues et al 1984;Esperanca-Pina and Camisao Soares O'Neill 1985) and microangiography on sectioned ovaries (dos Santos Ferreira et al 1974;Rodrigues et al 1984) have also been usefully applied to the study of the anatomy and topography of the ovarian vessels. In addition, direct observation of corroded or clarified vascular casts, after injection of colored latex (Del Campo and Ginther 1972;Hossain and O'Shea 1983), Micropaque (Esperanca-Pina and Reis 1984), vinylite (Reynolds 1947a(Reynolds ,b, 1948(Reynolds , 1973Delson et al 1949;Wydrzynski 1988), or other plastic compounds (Bendz et al 1982) into the ovarian artery of various mammals including humans have revealed important details of the ovarian vasculature.…”

Section: Introductionmentioning

confidence: 99%

The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts

Nottola

Macchiarelli

Motta

1997

Cell and Tissue Research

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Ovarian angioarchitecture was studied by scanning electron microscopy of vascular corrosion casts in estrous, pseudopregnant (stimulated with human chorionic gonadotropin) and pregnant rabbits. In all samples, the proper ovarian branch of the ovarian artery (ramus ovaricus) entered the ovarian hilus near the caudal pole of the organ and ran parallel to the major axis of the hilus. The extraovarian venous drainage was formed by several vessels emptying into a distal large vein. The ramus ovaricus exhibited various degrees of coiling and branched in the medulla. The coiling of the ramus ovaricus and its ramifications were maintained in all samples. A venous meshwork and/or flat vein branches closely enveloped the arterial coils found in the hilus and outer medulla. At this level numerous arteriovenous contacts were demonstrated in all samples. The coiled arteries, prior to entering the ovarian cortex, supplied several small peripheral follicles which were drained by the hilar veins. In the cortex the coiled arteries branched in numerous thin, straight or slightly undulated arterioles which supplied developing estrous follicles and pseudopregnant corpora lutea. The arterioles supplying the pregnant corpora lutea were long, large and tightly spiraled. The venous drainage followed the modifications of the arterial supply. These data demonstrate that ovarian cycle and pregnancy induced significant changes in the cortical vessels, which adapted their structure to the temporary functional needs of the recruited follicles or corpora lutea. Hilar and medullary vessels have permanent structures that may represent morphological devices for (a) a continuous control of the blood flow (spiral arteries) and (b) a local recirculation of endocrine products (arteriovenous contacts) comparable to the "countercurrent mechanism" previously shown to operate in ovaries of other species, but not yet found in rabbits.

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Angiographic Studies of the Extrinsic Vasculature of the Rabbit Ovary

Cited by 9 publications

References 10 publications

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

Blood flow in the ovary and adjacent structures of the non-pregnant sheep

The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts

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