The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts

Nottola, Stefania Annarita; Macchiarelli, Guido; Motta, Pietro M.

doi:10.1007/s004410050821

Cited by 18 publications

(29 citation statements)

References 38 publications

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“…This close anatomical relationship was described previously in other species, such as guinea-pigs 9 , rats 13 , rabbits 11,18 , mice 6 , primates such as Rhesus monkeys 8 and, baboons 21 .…”

Section: Discussionsupporting

confidence: 81%

The ovarian and uterine arteries in the chinchilla (Chinchilla lanigera)

Cevik-Demirkana

Ozdemira

Demirkan

2010

J. S. Afr. Vet. Assoc.

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The purpose of this study was to describe arteries supplying the ovaries and uterus in the chinchilla. Five healthy adult female chinchillas were used. In order to reveal the arterial network by dissecting under a stereoscopic microscope, latex coloured with red ink was injected through the common carotid artery. The ovaries of the chinchilla are supplied by the arteriae ovaricae which formed end-to-end anastomoses with the cranial termination of the arteria uterina. Soon after leaving the aorta abdominalis, the arteriae ovaricae extended 2-3mm caudolaterally, then released 1 branch and extended caudally and bifurcated into 2 further branches. One of these supplied branches to fat tissue. The other branch coursed caudally and anastomosed with the arteria circumflexa ilium profunda and dispersed into fat tissue. The arteria ovarica further subdivided into 2 rami ovaricae. The origins of the uterine arteries were exclusively from the left arteria iliaca externa. The arteria uterina gave a branch to the arteria umbilicalis and consecutive branches which supplied to the ureter, urinary bladder and cranial aspects of the vagina. It also gave rise to 2-3 branches to the cervix and further supplied 10-12 meandering branches to the uterine horns. The arteria uterina gave rise to many tortuous arteries to the uterus and provided 2 further branches to the ovary

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Section: Discussionsupporting

confidence: 81%

The ovarian and uterine arteries in the chinchilla (Chinchilla lanigera)

Cevik-Demirkana

Ozdemira

Demirkan

2010

J. S. Afr. Vet. Assoc.

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“…This technique allowed significant information on the ovarian cycle, and better clarified the role of vascular morphodynamics in the development of the LFC [37,[47][48][49]. In addition [8,50,51], the ovarian vascular pedicle and its proximal ramifications have been investigated by applying this technique.…”

Section: Historical Backgroundmentioning

confidence: 99%

“…The day one of pregnancy was taken to be the following day after mating. These animals were sacrificed at day 10 of pregnancy [8,37].…”

Section: Experimental Protocolmentioning

confidence: 99%

“…In rabbit, the ovarian artery, after branching from the aorta below the origin of the renal artery divides into two branches. The caudal branch serves the uterine tube and the uterine horn, and the cranial branch mainly supplies the ovary [8,10,18]. The venous drainage follows the same pathway of the arterial flow.…”

Section: Vascolarization Of the Hilus And Medullamentioning

confidence: 99%

“…These modifications, both functional and structural in nature, mainly involve the ovarian microvasculature supplying the luteo-follicular complex (LFC) [1][2][3][4][5]. In addition, the vessels forming the ovarian pedicle and running in the hilus have structural characteristics of relevant functional significance during the ovarian cycle [6][7][8].…”

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confidence: 99%

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The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

Macchiarelli

2000

Journal of Reproduction and Development

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Abstract. The vascular changes of the ovary were studied by scanning electron microscopy of vascular corrosion casts in estrous, pseudopregnant (stimulated with human chorionic gonadotropin -hCG) and pregnant rabbits. The results demonstrated that ovarian cycle and pregnancy may induce both structural and functional changes in the ovarian vessels. In fact the ovarian blood vessels adapted their structure to the temporary functional needs of the recruited follicles or corpora lutea. These changes involved both larger ovarian blood vessels (supplying the hilus and the medulla) and cortical blood vessels (supplying the luteo-follicular complexes). Hilar and medullary blood vessels also displayed morphological devices for the continuous control of the blood flow (spiral arteries) and for the local recirculation of endocrine products (artero-venous contacts). Such contacts, may likely sustain a "countercurrent mechanism" which was also shown in ovaries of other species. Scanning electron microscopy of vascular corrosion casts even demonstrated that cortical blood vessels are subjected to continuous remodeling. SEM showed different morphological types of vascular plexuses which supplied antral follicles (Types 1-2), atretic follicles (Types 3-4), peri-ovulatory follicles (Type 5), growing pseudopregnant corpora lutea (Type 6) regressing pseudopregnant corpora lutea (Type 7) and pregnant corpora lutea (Type 8). In estrous rabbit, growing to mature follicles (Types 1-2) showed a gradual enlargement and proliferation of the theca capillaries. These changes, associated with capillary hyperpermeabilization were observed in ovulatory and post-ovulatory follicles (Type 5), after hCG stimulation. The corpus luteum formation (Type 6 and 8) was accompanied by additional capillary dilation, diffuse angiogenetic sprouting and organization of conspicuous venous drainage which appeared more enhanced in pregnant (type 8) than in pseudopregnant (type 6) corpora lutea. The regression of the corpus luteum (Type 7) was characterized by the appearance of avascular areas within the gland and by regression of vascular dilatation. Finally, in estrous rabbit the atretic follicles (Types 3-4) wall showed large interruptions (avascular areas) and focal invasion of the central cavity by newly formed capillaries arranged randomly. The hCG stimulation did not affect consistently the interstitial microvasculature. It is concluded that the gradual increase of ovarian blood flow occuring during follicle growth and corpora lutea formation is provided by a functional adaptation of major ovarian vessels and by capillary functional (vasodilation) and structural (angiogenesis) support as well. Key words: Ovary, Blood vessels, Capillary, Corrosion casts, Angiogenesis, Scanning electron microscopy, Rabbit.(J. Reprod. Dev. 46: [207][208][209][210][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225] 2000) ndocrine and ovulatory activities of the ovary have strict and continuous relationship with -Reviewblood vessels changes. In fact...

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Morphological patterns of angiogenesis in ovarian follicle capillary networks. A scanning electron microscopy study of corrosion cast

Macchiarelli

Jiang

Nottola

et al. 2006

Microscopy Res & Technique

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To describe the morphological characteristics of the ovarian follicle (F) capillary neoformation and regression, the angiogenic figures were studied by means of scanning electron microscopy of corrosion casts in developing and mature F of rabbit, pig, and cow. Developing F showed gradual neoformation of thecal capillaries characterized by budding and then sprouting, likely from preexisting interstitial vessels. Postcapillary venules frequently showed vasoconstriction rings (sphincters). Vasodilation followed capillary elongation. Mature F, in addition to vessel elongation and dilation, also presented infolding of dilated capillary walls, followed by capillary duplication and sinusoidalization. Periovulatory F mainly showed functional changes, such as capillary dilation, signs of iperpermeabilization, and ischemia, the latter being limited to the apical follicular area. Vessel regression was characterized by thinning of capillaries and presence of avascular areas within the atretic F wall at any stage. This study showed two main types of angiogenic patterns. (a) longitudinal elongation (in series, sprouting angiogenesis) characterizing the initial phase of F development and (b) parallel duplication (in parallel, infolding or intussusceptive angiogenesis), ending in capillary lateral replication or splitting, secondary to functional microvascular changes. Indirect evidence of the establishment of postcapillary resistances contributing to capillary remodeling, was also shown. It is concluded that the sequence of capillary neoformation in mammalian ovarian F occurs in six steps: (1) budding, (2) sprouting (and elongation), (3) dilation, (4) infolding (intussusception), (5) duplication (splitting and elongation), and (6) sinusoidalization. Capillary regression hits F at any stage and characterizes F atresia.

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The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts

Cited by 18 publications

References 38 publications

The ovarian and uterine arteries in the chinchilla (Chinchilla lanigera)

The ovarian and uterine arteries in the chinchilla (Chinchilla lanigera)

The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

Morphological patterns of angiogenesis in ovarian follicle capillary networks. A scanning electron microscopy study of corrosion cast

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