The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials

Pourrajab, Behnaz; Fatahi, Somaye; Sohouli, Mohammad Hassan; Găman, Mihnea‐Alexandru; Shidfar, Farzad

doi:10.1080/10408398.2020.1821166

Cited by 50 publications

(41 citation statements)

References 104 publications

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“…38 Lastly, a systematic review and meta-analysis of randomized controlled trials found that probiotic/symbiotic supplementation can significantly increase serum TAC, glutathione and NO, as well as reduce MDA levels in adults. 39 In present study, we highlight that vitamin D supplementation in obese or overweight women who have an insufficiency or deficiency of vitamin D did not improve obesity indices and metabolic variables, indicating that this treatment must be proceeded with caution and following oxidative stress and inflammatory parameters.…”

Section: Discussionmentioning

confidence: 60%

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Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mamede¹,

Lima²,

Silva³

et al. 2021

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Aim The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. Methods Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 intervention. Patients in the supplemented group received a single oral megadose of VD3 (VD3, n=14). Patients in placebo group received a single oral identical capsule without vitamin D (placebo, n = 15). Anthropometric and biochemical variables were assessed at baseline and after 4-weeks intervention. Results Anthropometric variables (waist circumference, waist–hip ratio, waist–height ratio and body mass index) were similar between groups ( p > 0.05). VD3 supplementation increased the serum levels of 25-hydroxyvitamin D (p=0.000), malondialdehyde ( p =0.021) and C-reactive protein ( p =0.043) in overweight and obese women. Additionally, VD3 supplementation reduced the serum levels of aspartate aminotransferase (AST, p =0.035), alanine aminotransferase (ALT, p <0.0001) in overweight and obese women. Despite this, the serum levels of parathyroid hormone (PTH), fasting glucose (FG), and alpha-1- acid glycoprotein (A1GPA), total antioxidant capacity (TAC) were similar between groups. Conclusion In summary, a single oral megadose of VD3 increased 25-hydroxyvitamin D serum levels but did not improve oxidative stress and inflammation markers.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mamede¹,

Lima²,

Silva³

et al. 2021

DMSO

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“… 26 , 27 Another study illustrated that obesity and T2DM are associated with increased levels of oxidative stress, 28 and several oxidative stress markers have been associated with diabetes. 29 Adipose tissue represents the largest endocrine organ and produces adipokines that stimulate the generation of oxidative substances, which can further affect the occurrence of diabetes. Therefore, programs and strategies for controlling obesity should be established and strengthened to reduce the incidence of T2DM in China.…”

Section: Discussionmentioning

confidence: 99%

Association Between Different Obesity Patterns and the Risk of Developing Type 2 Diabetes Mellitus Among Adults in Eastern China: A Cross-Sectional Study

Yang

et al. 2021

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Purpose Obesity has become a public health challenge worldwide and can lead to the development of diabetes. However, studies examining the associations between different obesity patterns and the development of type 2 diabetes mellitus (T2DM) in China are limited. Therefore, this study aimed to explore the associations between three obesity patterns and the risk of T2DM development in Eastern China. Methods A cross-sectional study was conducted at our health examination center, involving 5860 adults, from June to December 2019. Data, including sociodemographic information, lifestyle, and biochemical measurements, were collected, and obesity was classified into three patterns: overweight and general obesity, abdominal obesity, and compound obesity. Multivariate logistic regression was used to assess the associations between different obesity patterns and T2DM risk after adjustment for confounding factors. Subgroup analysis was used to further explore the associations between obesity patterns and T2DM risk. Results A total of 5860 subjects were enrolled in this study. A significant difference in the T2DM incidence was observed between men and women with normal weight or overweight and general obesity ( p < 0.05); however, no significant differences were observed between men and women with abdominal obesity and compound obesity. After multivariable adjustment, multivariate logistic regression analysis showed that the odds ratios (ORs) [95% confidence interval (CI)] for T2DM in individuals with abdominal and compound obesity were 1.55 [1.08–2.24] and 1.85 [1.25–2.73], respectively, compared with the normal-weight group. Subgroup analysis showed that different obesity patterns were not independent risk factors for T2DM development among adults aged ≥ 60 years, whereas abdominal and compound obesity were highly associated with the risk of T2DM development among individuals who report current smoking or alcohol drinking. Conclusion Abdominal obesity and compound obesity are risk factors for T2DM. More attention should be paid to obesity prevention among individuals younger than 60 years and improving control of cigarette and alcohol abuse.

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“…[ 39 ] It was reported that in T2DM, reactive oxygen species (ROS) levels were found to be increased and that the elevation is more pronounced in obese patients with T2DM. [ 40 ] Further, dyslipidemia was reported to be a trigger for CAD in patients with diabetes in a Romanian population, as it is an initiation factor of the dyslipidemia-inflammation-T2DM-cardiovascular signaling pathway. [ 41 ] The patients enrolled in our study were overweight (with a mean BMI of 25.96) and had CAD and T2DM; therefore, their levels of inflammation and ROS were elevated.…”

Section: Discussionmentioning

confidence: 99%

Association of dipeptidyl peptidase IV polymorphism, serum lipid profile, and coronary artery stenosis in patients with coronary artery disease and type 2 diabetes

et al. 2021

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Cardiovascular disease (CAD) is a devastating illness, but to date there are limited means of predicting a person's coronary stenosis severity and their prognosis. The study was performed to investigate the relationship between dipeptidyl peptidase 4( DPP4 ) gene polymorphisms and serum lipid profiles, as well as the severity of coronary artery stenosis in patients with CAD and type 2 diabetes (T2DM) for the first time. Herein, 201 patients with CAD and T2DM were enrolled in the Department of Cardiology, Shandong Provincial Qianfoshan Hospital. DPP4 rs3788979 and rs7608798 single nucleotide polymorphisms (SNPs) were genotyped. The general information of all patients was collected, and the associations between DPP4 SNPs and lipid profiles were detected. At the same time, association between SNP polymorphisms and the degree of coronary artery stenosis were analyzed. There was a significant difference in apolipoprotein B (ApoB) levels ( P = .011) for the rs3788979 polymorphism, while no difference was identified in other blood lipids or with other mutations. SNP mutation of A to G in rs3788979 was associated with a reduced percentage of severe coronary artery stenosis in female patients ( P = .023) as well as those with nosmoking ( P = .030), nodrinking ( P = 0.007), and nocardiovascular family history ( P = 0.015). G allele of rs3788979 is associated with a reduced ApoB level. Besides, we suggest that G allele in rs3788979 may have a cardioprotective effect and prove to be a useful and specific measure when predicting a patient's coronary stenosis severity if diagnosed with CAD and T2DM.

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The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials

Cited by 50 publications

References 104 publications

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Association Between Different Obesity Patterns and the Risk of Developing Type 2 Diabetes Mellitus Among Adults in Eastern China: A Cross-Sectional Study

Association of dipeptidyl peptidase IV polymorphism, serum lipid profile, and coronary artery stenosis in patients with coronary artery disease and type 2 diabetes

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