The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review

Li, Ya; Wu, You; Wu, Lili; Qin, Lingling; Liu, Tonghua

doi:10.1186/s12967-022-03695-y

Cited by 10 publications

(7 citation statements)

References 89 publications

(103 reference statements)

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“…Our research has recommended that probiotics could improve HOMA-IR and HDL in managing glucose homeostasis. However, previous studies [ 28 ] have shown that probiotics do not have a statistically significant effect on HOMA-IR and HDL. The main reason is the differences in the included articles.…”

Section: Discussionmentioning

confidence: 92%

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The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis

Sun,

Liu,

et al. 2024

Journal of Diabetes Research

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Background and Purpose. There is controversy about the effect of probiotics in regulating glucose homeostasis. This systematic review and meta-analysis is aimed at evaluating the evidence for the efficacy of probiotics in managing blood glucose, blood lipid, and inflammatory factors in adults with prediabetes. Methods. The Preferred Reporting Items for Systematic Reviews and Analysis checklist was used. A comprehensive literature search of the PubMed, Embase, and Cochrane Library databases was conducted through August 2022 to assess the impact of probiotics on blood glucose, lipid, and inflammatory markers in adults with prediabetes. Data were pooled using a random effects model and were expressed as standardized mean differences (SMDs) and 95% confidence interval (CI). Heterogeneity was evaluated and quantified as I2. Results. Seven publications with a total of 550 patients were included in the meta-analysis. Probiotics were found to significantly reduce the levels of glycosylated hemoglobin (HbA1c) (SMD -0.44; 95% CI -0.84, -0.05; p=0.03; I2=76.13%, p<0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (SMD -0.27; 95% CI -0.45, -0.09; p<0.001; I2=0.50%, p=0.36) and improve the levels of high-density lipoprotein cholesterol (HDL) (SMD -8.94; 95% CI -14.91, -2.97; p=0.003; I2=80.24%, p<0.001), when compared to the placebo group. However, no significant difference was observed in fasting blood glucose, insulin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, interleukin-6, tumor necrosis factor-α, and body mass index. Subgroup analyses showed that probiotics significantly reduced HbA1c in adults with prediabetes in Oceania, intervention duration of ≥3 months, and sample size <30. Conclusions. Collectively, our meta-analysis revealed that probiotics had a significant impact on reducing the levels of HbA1c and HOMA-IR and improving the level of HDL in adults with prediabetes, which indicated a potential role in regulating blood glucose homeostasis. However, given the limited number of studies included in this analysis and the potential for bias, further large-scale, higher-quality randomized controlled trials are needed to confirm these findings. This trial is registered with CRD42022358379.

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Section: Discussionmentioning

confidence: 92%

“…Compared to a recent study [ 28 ], there are some novelties in our work. Firstly, considering the differences between adolescents and adults, we only explored the effects of probiotics on prediabetes in adults.…”

Section: Discussionmentioning

confidence: 95%

The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis

Sun,

Liu,

et al. 2024

Journal of Diabetes Research

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“…Oh et al 30 reported a significant decrease in HbA1c in 40 participants with prediabetes taking L. plantarum HAC01 for 8 weeks; however, studies involving an intake of ≥12 weeks provide valuable information. A recent meta‐analysis and systematic review showed that probiotics could decrease HbA1c levels in patients with prediabetes; none of the adopted studies was sufficient to evaluate the post‐observation period after discontinuation 31 . The 8‐week post‐observation period in the current study considered the time‐related characteristics of changes in HbA1c levels and allowed us to assess properly the impact of food interventions on these levels.…”

Section: Discussionmentioning

confidence: 99%

“…A recent meta-analysis and systematic review showed that probiotics could decrease HbA1c levels in patients with prediabetes; none of the adopted studies was sufficient to evaluate the post-observation period after discontinuation. 31 The 8-week post-observation period in the current study considered the time-related characteristics of changes in HbA1c levels and allowed us to assess properly the impact of food interventions on these levels.…”

Section: Discussionmentioning

confidence: 99%

Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 improves glycaemic control in adults with prediabetes in a randomized, double‐blind, placebo‐controlled trial

Toshimitsu,

Gotou,

Sashihara

et al. 2024

Diabetes Obesity Metabolism

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AimThe ingestion of Lactiplantibacillus plantarum OLL2712 (OLL2712) cells has been shown to improve glucose metabolism by suppressing chronic inflammation in murine models and clinical studies. This study aimed to clarify the effect of OLL2712 on glycaemic control in healthy adults with prediabetes.Materials and MethodsThe study was a randomized, double‐blind, placebo‐controlled, parallel‐group design. Adult participants with prediabetes [n = 148, glycated haemoglobin (HbA1c) range: 5.6%‐6.4%, age range: 20‐64 years] were assigned randomly to placebo or OLL2712 groups (n = 74/group) and administered daily for 12 weeks either conventional yogurt or yogurt containing >5 × 109 heat‐treated OLL2712 cells, respectively. In addition, the participants were followed for 8 weeks after the discontinuation of either yogurt. The primary outcome was the changes in HbA1c levels at weeks 12 and 16 by analysis of covariance.ResultsThe levels of HbA1c and glycoalbumin decreased significantly in both groups at week 12 in comparison with those at week 0, but only in the OLL2712 group at week 16. HbA1c levels decreased significantly at weeks 12 and 16 in the OLL2712 group in comparison with the placebo group (p = .014 and p = .006, respectively). No significant inter‐ and intragroup differences in HbA1c levels were observed at week 20.ConclusionsThe ingestion of OLL2712 prevents the deterioration of glycaemic control and maintains the HbA1c levels within the normal range in adults with prediabetes; yogurt probably exhibits similar effects, which may contribute to reducing the risk of developing type 2 diabetes.

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“…The meta-analysis, therefore, concluded that probiotics may play an important role in the regulation of HbA1c, QUICKI, total and LDL cholesterol, and TG in patients with prediabetes. Furthermore, based on existing studies, probiotics can regulate blood glucose homeostasis in various ways [154].…”

Section: Dietary Supplementation With Probioticsmentioning

confidence: 99%

A Narrative Review on Strategies for the Reversion of Prediabetes to Normoglycemia: Food Pyramid, Physical Activity, and Self-Monitoring Innovative Glucose Devices

Rondanelli,

Barrile,

Cavioni

et al. 2023

Nutrients

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In 2019, “Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report” was published. This consensus report, however, did not provide an easy way to illustrate to subjects with prediabetes (SwPs) how to follow a correct dietary approach. The purpose of this review is to evaluate current evidence on optimum dietary treatment of SwPs and to provide a food pyramid for this population. The pyramid built shows that everyday consumption should consist of: whole-grain bread or potatoes eaten with their skins (for fiber and magnesium) and low glycemic index carbohydrates (GI < 55%) (three portions); fruit and vegetables (5 portions), in particular, green leafy vegetables (for fiber, magnesium, and polyphenols); EVO oil (almost 8 g); nuts (30 g, in particular, pistachios and almonds); three portions of dairy products (milk/yogurt: 300–400 g/day); mineral water (almost 1, 5 L/day for calcium intake); one glass of wine (125 mL); and three cups of coffee. Weekly portions should include fish (four portions), white meat (two portions), protein plant-based food (four portions), eggs (egg portions), and red/processed meats (once/week). At the top of the pyramid, there are two pennants: a green one means that SwPs need some personalized supplementation (if daily requirements cannot be satisfied through diet, vitamin D, omega-3, and vitamin B supplements), and a red one means there are some foods and factors that are banned (simple sugar, refined carbohydrates, and a sedentary lifestyle). Three to four times a week of aerobic and resistance exercises must be performed for 30–40 min. Finally, self-monitoring innovative salivary glucose devices could contribute to the reversion of prediabetes to normoglycemia.

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The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review

Cited by 10 publications

References 89 publications

The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis

The Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis

Ingesting probiotic yogurt containing Lactiplantibacillus plantarum OLL2712 improves glycaemic control in adults with prediabetes in a randomized, double‐blind, placebo‐controlled trial

A Narrative Review on Strategies for the Reversion of Prediabetes to Normoglycemia: Food Pyramid, Physical Activity, and Self-Monitoring Innovative Glucose Devices

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