The effects of preoperative rofecoxib, metoclopramide, dexamethasone, and ondansetron on postoperative pain and nausea in patients undergoing elective laparoscopic cholecystectomy

Abstract

The use of this preoperative regimen resulted in decreased LOS, maximum pain, and nausea ratings. Patients in the intervention group required less postoperative anti-emetics.

A systematic review of interventions to facilitate ambulatory laparoscopic cholecystectomy

“…All three studies showed decreased postoperative pain scores and a reduced requirement for postoperative opioid analgesia. Four trials 2,30–32 evaluated COX II inhibitors. All four trials showed a reduction in postoperative pain and two trials 30,31 reported increased patient satisfaction.…”

“…Laparoscopic cholecystectomy (LC) is currently accepted as the reference standard for the management of symptomatic or complicated gallstone disease. There is now increasing evidence to support ambulatory LC as the standard of care as a result of its ability to improve patient recovery and significantly reduce hospital stay 1–4 . Laparoscopic cholecystectomy would appear to be an ideal operation for ambulatory surgery because it is of short duration, uses small incisions, carries a low rate of immediate complications and does not disrupt gastrointestinal homeostasis.…”

Comparison of the effects of intravenous metoclopramide and ondansetron on prevention of nausea and vomiting after cesarean section

“…digestive tract and stimulates bowel movement. Furthermore, since metoclopramide enhances the esophageal sphincter resting pressure, it can limit reflux of the gastric contents to the esophagus through broadening the range of the esophageal contractions [6][7][8].…”