“…It integrates fusion, mixing, compression, and shearing in an axial space to blend materials at the molecular level. The dissolution and absorption properties and the oral bioavailability of drugs with high dispersion are greatly improved (Feng, Vo et al, 2015;Feng, Ye et al, 2015;Sareen, Mathew, & Joseph, 2012). HME can also increase the stability of microencapsulated drugs (Sarode, Sandhu, Shah, Malick, & Zia, 2013).…”