Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology

Bhagurkar, Ajinkya M.; Darji, Mittal; Lakhani, Prit; Thipsay, Priyanka; Bandari, Suresh; Repka, Michael A.

doi:10.1111/jphp.13046

Cited by 26 publications

(4 citation statements)

References 43 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Presently the most extensively investigated technique for the preparation of buccal film is solvent casting technique [ 186 ] compared to hot-melt extrusion [ 187 ] and emerging 3D inkjet printing [ 188 ] method. Similar to manufacture of oral films, continuous fabrication of buccal film is efficiently adaptable for mechanization.…”

Section: Preparation Methods Scale-up Process and Manufacturing Considerationsmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

View full text Add to dashboard Cite

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in vitro techniques frequently used for examining buccal drug-delivery systems. The role of mucoadhesive polymers, penetration enhancers, and enzyme inhibitors to circumvent the formulation challenges particularly due to salivary renovation cycle, masticatory effect, and limited absorption area are summarized. Biocompatible mucoadhesive films and patches are favored dosage forms for buccal administration because of flexibility, comfort, lightness, acceptability, capacity to withstand mechanical stress, and customized size. Preparation methods, scale-up process and manufacturing of buccal films are briefed. Ongoing and completed clinical trials of buccal film formulations designed for systemic delivery are tabulated. Polymeric or lipid nanocarriers incorporated in buccal film to resolve potential formulation and drug-delivery issues are reviewed. Vaccine-enabled buccal films have the potential ability to produce both antibodies mediated and cell mediated immunity. Advent of novel 3D printing technologies with built-in flexibility would allow multiple drug combinations as well as compartmentalization to separate incompatible drugs. Exploring new functional excipients with potential capacity for permeation enhancement of particularly large-molecular-weight hydrophilic drugs and unstable proteins, oligonucleotides are the need of the hour for rapid advancement in the exciting field of buccal drug delivery.

show abstract

Section: Preparation Methods Scale-up Process and Manufacturing Considerationsmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Evidence provided to support the selection of formulation compositions to produce hot-melt extruded mucoadhesive films [199] Mucoadhesive buccal film PEO N10/HPMC/Eudragit RL100 Domperidone HME is a viable technique for the preparation of buccal-adhesive films with improved drug bioavailability [200] Mucoadhesive oral tablet PEO/HPMC Pioglitazone/felodipine…”

Section: Jelly Fig Polysaccharide/pullulanmentioning

confidence: 99%

Polymeric Biomaterials for Topical Drug Delivery in the Oral Cavity: Advances on Devices and Manufacturing Technologies

et al. 2022

View full text Add to dashboard Cite

There are several routes of drug administration, and each one has advantages and limitations. In the case of the topical application in the oral cavity, comprising the buccal, sublingual, palatal, and gingival regions, the advantage is that it is painless, non-invasive, allows easy application of the formulation, and it is capable of avoiding the need of drug swallowing by the patient, a matter of relevance for children and the elderly. Another advantage is the high permeability of the oral mucosa, which may deliver very high amounts of medication rapidly to the bloodstream without significant damage to the stomach. This route also allows the local treatment of lesions that affect the oral cavity, as an alternative to systemic approaches involving injection-based methods and oral medications that require drug swallowing. Thus, this drug delivery route has been arousing great interest in the pharmaceutical industry. This review aims to condense information on the types of biomaterials and polymers used for this functionality, as well as on production methods and market perspectives of this topical drug delivery route.

show abstract

“…Buccal films are the potential formulations for the effective delivery of nutraceuticals due to their versatility and flexibility. Further, these mucoadhesive films can remain in contact with the oral mucosa and provide prolonged release in the direction of the oral mucosa or toward the oral cavity [54]. Food and Drug Administration (FDA) defined three different types for films [55]:…”

Section: Buccal Filmsmentioning

confidence: 99%

Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals

Subramanian

2021

Foods

View full text Add to dashboard Cite

The conventional oral administration of many nutraceuticals exhibits poor oral bioavailability due to the harsh gastric conditions and first-pass metabolism. Oral mucosa has been recognized as a potential site for the delivery of therapeutic compounds. The mucoadhesive formulation can adhere to the mucosal membrane through various interaction mechanisms and enhance the retention and permeability of bioactive compounds. Absorption of bioactive compounds from the mucosa can improve bioavailability, as this route bypasses the hepatic first-pass metabolism and transit through the gastrointestinal tract. The mucosal administration is convenient, simple to access, and reported for increasing the bioactive concentration in plasma. Many mucoadhesive polymers, emulsifiers, thickeners used for the pharmaceutical formulation are accepted in the food sector. Introducing mucoadhesive formulations specific to the nutraceutical sector will be a game-changer as we are still looking for different ways to improve the bioavailability of many bioactive compounds. This article describes the overview of buccal mucosa, the concept of mucoadhesion and related theories, and different techniques of mucoadhesive formulations. Finally, the classification of mucoadhesive polymers and the mucoadhesive systems designed for the effective delivery of bioactive compounds are presented.

show abstract

Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology

Cited by 26 publications

References 43 publications

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Polymeric Biomaterials for Topical Drug Delivery in the Oral Cavity: Advances on Devices and Manufacturing Technologies

Mucoadhesive Delivery System: A Smart Way to Improve Bioavailability of Nutraceuticals

Contact Info

Product

Resources

About