The effects of polychlorinated biphenyls on calciferol (vitamin D) mediated calcium metabolism

Wong, Richard G.; Nowicki, Henry G.; Norman, Anthony W.

doi:10.1016/0048-3575(74)90096-0

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…Their results indicated that dietary PCBs increased the incidence of exudative diathesis in chicks and that this increase can be overcome by increasing dietary vitamin E or selenium. The vitamin D mediated calcium metabolism was found to be altered by the oral administration of PCBs to chickens (70).…”

mentioning

confidence: 99%

Metabolism and biochemical toxicity of PCBs and PBBs

Matthews¹,

Fries²,

Gardner³

et al. 1978

Environ Health Perspect

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mentioning

confidence: 99%

Metabolism and biochemical toxicity of PCBs and PBBs

Matthews¹,

Fries²,

Gardner³

et al. 1978

Environ Health Perspect

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“…PCBs and PBBs administered are relatively high concentrations, usually 50 ppm or higher in the diet, to laboratory animals have been shown to cause porphyria (27), disfunction of the thyroid (28), inhibition of various enzymes (29), changes in the liver to body weight ratios (30), various disorders of the liver (31), and to alter the level or utilization of corticosteroids (32),' and vitamins A, D, and E (33)(34)(35).…”

Section: Metabolism and Biochemical Toxicitymentioning

confidence: 99%

General summary and conslusions

1978

Environ Health Perspect

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The great complexity of PCB commercial mixtures has provided the difficult task of separating the components of these mixtures and determining the complete identity of the compounds. Efforts to define these mixtures have been quite successful over the past several years (1). Identification of the component chemicals in PCB residues presents another difficult problem. Little progress has been reported in this area. Since the fate of components of commercial PCB mixtures entering the environment cannot be followed directly, inferences must be drawn about chemical alteration of chlorinated biphenyl compounds in the environment mainly based on laboratory studies. The known resistance of aryl chlorides to chemical oxidation and hydrolysis presumably was a major factor in the promotion of PCBs for industrial uses. Exposure to nonmetabolic environmental agents is unlikely to result in significant oxidation or hydrolysis of chlorinated biphenyls. However, since appreciable photoalteration of chlorinated biphenyls has been observed using either sunlight or sunlight-simulating lamps in the laboratory (1) as energy sources, it is highly probable that photochemical changes occur in the environment. These photochemical studies have indicated that reductive dechlorination to biphenyls of lower chlorine content is a predominant alteration route although for

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