The Effects of Platelet-Rich-Plasma (PRP) Injection on Ligament Injury

Kloping, Yudhistira Pradnyan; Desnantyo, Andre Triadi; Rehatta, Nancy Margaritha

doi:10.15562/bmj.v5i1.174

Cited by 4 publications

(5 citation statements)

References 4 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PRP’s efficacy comes from the various growth factors which are released from alpha granules of activated platelets, specifically platelet-derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and insulin-like growth factor (IGF-I) 2 , 3 , 6 , 7 . The degranulation also acts as chemoattractant for macrophages to take part in the healing process 8 .…”

Section: Discussionmentioning

confidence: 99%

“…The degranulation also acts as chemoattractant for macrophages to take part in the healing process 8 . Based on previous literatures, increased platelet concentration is believed to escalate the total growth factors released, which enhance healing and the regeneration process 2 , 6 , 9 , 10 . The enhancement of the migratory ability leads to a better regeneration capability and slows down the natural progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Although PRP injection has minor side effects to a certain degree, the advantages of not having cross reactivity and immune reaction or disease transmission risks are much more valuable. PRP can be the lead alternative for soft tissue pain therapy due to its autologous nature 2 , 3 , 6 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Platelet Rich Plasma Injection for Soft Tissue Musculoskeletal Pain

Irianto¹,

Ah²,

Kloping³

2021

Malays Orthop J

View full text Add to dashboard Cite

Introduction: Treating soft tissue injuries can be a challenge for physicians as it can be overlooked which can lead to more problems. In recent studies, the use of Platelet Rich Plasma (PRP) has been gaining popularity for soft tissue injuries because of its benefits and minimal side effects. This study aims to evaluate the effect of PRP injection on various musculoskeletal soft tissues inflammation. Material and Methods: This is a retrospective study of patients with soft tissue injury who underwent PRP therapy between 2015 and 2018 at an orthopaedic and traumatology hospital. The study collected demographic data including the type of soft tissue injury and Visual Analog Scale (VAS) before and after the PRP injection. Those data were statistically analysed to identify the significance of PRP. Results: Seventy-six patients were included, predominantly female, middle aged (40-69 years old) and class one obesity. Most of the complaints (61.8%) were in the lower extremity region. Pain improvements measured with mean VAS score were observed in both acute (3.06±1.28 to 0.8±0.65) and chronic (4±1.75 to 0.97±0.62) cases. There was a significant decrease of VAS score before and after the PRP injection (p < 0.000). Conclusion: PRP injection is able to alleviate both acute and chronic pain in soft tissue injuries without additional analgesic.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Platelet Rich Plasma Injection for Soft Tissue Musculoskeletal Pain

Irianto¹,

Ah²,

Kloping³

2021

Malays Orthop J

View full text Add to dashboard Cite

show abstract

“…Several types of treatment are available or under development, namely, surgery, growth factor replacement, neuroprotectant (N-acetylcysteine and acetyl-L-carnitine), nerve guidance sca old for nerve gaps, hormone therapy, and stem cells [5]. Amongst the novel treatment option, platelet-rich plasma (PRP) injection has been found to be a promising method of delivering appropriate growth factors to the injured nerve and consequently help hasten nerve repair [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study

Pandunugrahadi

Irianto

Sindrawati

2022

International Journal of Biomaterials

View full text Add to dashboard Cite

Introduction. Without appropriate treatment, nerve injuries may result in permanent loss of function. Platelet-rich plasma (PRP) injection is found to help in nerve regeneration. PRP is a concentrated platelet derived from autologous blood with the potential to release various growth factors (GF) to promote nerve regeneration. This study aims to know the best time for PRP injection to promote nerve regeneration. Methods. This is an experimental in vivo research using male New Zealand white rabbits in the randomized control group posttest only design. Samples were divided into 5 groups (1 control group and 4 treatment groups). The control group without PRP injection and treated groups injected immediately after nerve injury, 3 days, 7 days, and 14 days afterward. Nerve regeneration was evaluated by the histology specimen sacrificed on day 21. Inflammation cells and endoneurium vacuoles were counted as mean percentage of five nerve fragments in each injured nerve sample specimen. Result. Inflammation cells and vacuole cells increased significantly when PRP was administered 3 days after injury (group 2) (respectively, 14 ± 6.7 and 56.6 ± 11.6) compared to all treatment groups ( p < 0.005 ) (control group, respectively, 6 ± 2.6 and 15.7 ± 9.5). On the other hand, significantly lower endoneurium vacuoles and inflammation cells were found on “the day 14” sample group (respectively, 5 ± 1.3 and 5.2 ± 1.6) compared to all other groups ( p < 0.005 ). Conclusion. This study found that the best time for injecting PRP for nerve regeneration is 14 days after injury.

show abstract

“…PRP telah dikenal luas untuk penyembuhan luka pada tulang apalagi bagi atlet olahraga yang sering mengalami cedera (Kloping et al, 2016). Dikutip pada (Rohmah, 2021) Platelet rich plasma (PRP) didefinisikan sebagai 1.000.000 platelet/μL dalam sebagian fraksi plasma darah autologus (diambil dari tubuh pasien sendiri).…”

unclassified

Potensi Platelet Rich Plasma (PRP) Untuk Kecantikan Alami Kulit Wanita

Dewi¹

2021

Jurnal Tadris IPA Indonesia

View full text Add to dashboard Cite

RPlatelet rich plasma merupakan komponen darah produk aktif biologis dengan khasnya yang kaya trombosit. Akhir – akhir ini, platelet rich plasma mendapat pusat perhatian karena potensinya terhadap perawatan kecantikan kulit meskipun perhatian belum penuh karena belum akuratnya jawaban penelitian manfaat platelet rich plasma untuk kecantikan. Penulisan artikel dimaksudkan untuk mendapatkan informasi mengenai potensi platelet rich plasma untuk kecantikan kulit wanita alami. Metode penelitian kali ini menggunakan studi literatur untuk mendapatkan data berupa manfaat – manfaat platelet rich plasma untuk kecantikan terutama untuk kulit. Pada artikel juga menginformasikan fokus utama manfaat platelet rich plasma untuk penyembuhan tulang, ligamen dan lain sebagainya. Sebanyak 13 jurnal yang didapat dalam penelitian ini yang mengungkapkan banyaknya manfaat platelet rich plasma untuk kecantikan, diantaranya untuk peremajaan kulit (remodelling kulit saat terjadi penuaan), mempercepat peningkatan produksi kolagen, augmentasi volume kulit dan masalah kulit lain. Dengan ini, potensi platelet rich plasma kaya akan manfaatnya baik untuk tulang, luka, ataupun kecantikan yang kini bisa menjadi solusi perawatan alami untuk kecantikan kulit wanita. Namun demikian, praktik platelet rich plasma untuk perawatan kecantikan tidak tahan lama dibandingkan dengan operasi plastik.

show abstract

The Effects of Platelet-Rich-Plasma (PRP) Injection on Ligament Injury

Cited by 4 publications

References 4 publications

Platelet Rich Plasma Injection for Soft Tissue Musculoskeletal Pain

Platelet Rich Plasma Injection for Soft Tissue Musculoskeletal Pain

The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study

Potensi Platelet Rich Plasma (PRP) Untuk Kecantikan Alami Kulit Wanita

Contact Info

Product

Resources

About