Introduction. Without appropriate treatment, nerve injuries may result in permanent loss of function. Platelet-rich plasma (PRP) injection is found to help in nerve regeneration. PRP is a concentrated platelet derived from autologous blood with the potential to release various growth factors (GF) to promote nerve regeneration. This study aims to know the best time for PRP injection to promote nerve regeneration. Methods. This is an experimental in vivo research using male New Zealand white rabbits in the randomized control group posttest only design. Samples were divided into 5 groups (1 control group and 4 treatment groups). The control group without PRP injection and treated groups injected immediately after nerve injury, 3 days, 7 days, and 14 days afterward. Nerve regeneration was evaluated by the histology specimen sacrificed on day 21. Inflammation cells and endoneurium vacuoles were counted as mean percentage of five nerve fragments in each injured nerve sample specimen. Result. Inflammation cells and vacuole cells increased significantly when PRP was administered 3 days after injury (group 2) (respectively, 14 ± 6.7 and 56.6 ± 11.6) compared to all treatment groups ( p < 0.005 ) (control group, respectively, 6 ± 2.6 and 15.7 ± 9.5). On the other hand, significantly lower endoneurium vacuoles and inflammation cells were found on “the day 14” sample group (respectively, 5 ± 1.3 and 5.2 ± 1.6) compared to all other groups ( p < 0.005 ). Conclusion. This study found that the best time for injecting PRP for nerve regeneration is 14 days after injury.
IntroductionLow back pain is a very common disorder and often hinders our daily activities. There are several treatment options for LBP management. This study aims to determine differences in patient recovery to return to work evaluated based on VAS, Roland Morris Disability Questionnaire (RMDQ) and Oswestry Low Back Pain Disability Questionnaire (ODI) after spinal injection with oral analgesics and muscle relaxants in patients with chronic low back pain. MethodsThis is a randomized controlled trial study on patients with LBP undergoing conservative therapies at the Orthopaedic outpatient clinic from February -March 2019. Inclusion began from when patients were admitted to the clinic in February 2019 until March 2019. Mean scores between two treatment groups were compared. Functional evaluation on patients with low back pain is commonly done using questionnaire. Spinal Injection contained a combination of lidocaine and triamcinolone acetonide. Oral therapy containing a combination of paracetamol 325mg and tramadol 37.5mg were given 3 times daily for 3 weeks, along with Eperisone 50mg which acted as a muscle relaxant. Data then was analysed descriptively and statistically Result 32 patiens were included in this study with 16 patients in each treatment groups. The mean age of the patients is 42. Patients VAS, RMDQ, and ODI score were measured before the treatment, after 1 week, 2 weeks and 3 weeks. the results were shown in Table 1. All study parameters were shown improvements with increasing time. LBP treated with Spinal injection were clinically and statistically better compared to oral therapy ConclusionSpinal injection method with lidocaine and triamcinoloan acetonide is better than oral analgesic therapy with the parameters used in this study
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