The effects of plasticizers on the ovary

Neff, Alison M.; Flaws, Jodi A.

doi:10.1016/j.coemr.2021.01.004

Cited by 11 publications

(5 citation statements)

References 49 publications

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“…Finally, our data outlined a non-monotonic mode of action for DiNP ( 17 , 18 , 42 ), where lower concentrations seem to disrupt the ovarian function. This is not an unusual characteristic of environmental contaminants acting as endocrine disrupting chemicals (EDCs), such as phthalates, which can interact with multiple receptor-mediated endocrine and metabolic pathways ( 50 – 52 ).…”

Section: Discussionmentioning

confidence: 71%

“…We here reported that exposure to DiNP altered CAS3 signal and DNA fragmentation in follicular cells and that DiNP could induce apoptotic processes in the zebrafish ovary, accordingly with previous observations in rats treated with DiNP and other phthalate congeners ( 20 , 40 , 41 ). Furthermore, there is evidence that plasticizers, in general, exert deleterious effects by inducing oxidative stress in rodent ovary, dysregulating steroid production and activating cell death mechanisms ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary

et al. 2021

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Di-isononyl phthalate (DiNP) is a plasticizer reported to elicit hormone-like activity and disrupt metabolism and reproduction in fish and other vertebrates. In general, phthalates have been used at high concentrations beyond reported environmental levels to assess their adverse effects on fish gonadal physiology. The present study exposed adult female zebrafish to a wide range of DiNP concentrations [0.42 µg L−1 (10−9 M), 4.2 µg L−1 (10−8 M), and 42 µg L−1 (10−7 M)] for 21 days. We evaluated gene expression profiles related to apoptosis, autophagy, and oxidative stress; DNA fragmentation (TUNEL assay: terminal deoxynucleotidyl transferase dUTP nick end labeling) and caspase activity (CAS3) were also examined. Exposure to 0.42 and 4.2 µg L−1 upregulated the genes coding for tnfa and baxa, sod1, prkaa1, respectively. CAS3 immunohistochemistry revealed a higher number of positive vitellogenic oocytes in ovaries exposed to 0.42 µg L−1. Subsequently, we examined the relationship between CAS3 signaling and DNA fragmentation. Accordingly, DNA fragmentation was observed in vitellogenic follicles of fish exposed to 0.42 and 4.2 μg L−1. Our results demonstrate that follicular atresia can occur after exposure to environmental levels of DiNP for 21 days, which may adversely affect the reproductive performance of female zebrafish in a non-monotonic manner.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary

et al. 2021

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“…Furthermore, it is known that the death of granulosa cells, induced by oxidative stress, is one of the main causes of follicular atresia (Zhang et al, 2021). There is evidence to show that xenoestrogens, such as bisphenol and phthalate, induce oxidative stress in the ovaries of rodents (Neff & Flaws, 2021). Thus, the increase in oxidative stress observed in the zebrafish ovaries, in response to PPF exposure, may be related to the tendency toward increased atresia and, consequently, to the inhibition of follicle maturation.…”

Section: Discussionmentioning

confidence: 99%

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Oliveira

Marins

Mendes

et al. 2023

J of Applied Toxicology

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We analyzed the effects of pyriproxyfen (PPF) on oxidative stress and ovarian morphology in zebrafish. PPF (10−9 M) exposure increased reactive oxygen species generation in ovaries, in association with a decrease in glutathione content. The activities of glutathione S‐transferase, superoxide dismutase, and catalase were increased, while γ‐glutamyltransferase activity was not altered by pesticide treatment. The histology of ovarian tissue showed an increase in the number of previtellogenic oocytes I, and a decrease in the rate of vitellogenic oocyte (VIT) count, suggesting inhibition of follicular maturation. An increase in the thickness of the vitelline envelope was observed in VIT, as was a tendency toward an increase in atresia in the ovary of the PPF‐treated group. These findings indicate that the deleterious effect of PPF on ovarian maturation is mediated by a redox imbalance and oxidative damage. So, PPF acts as an endocrine disruptor chemical and may compromise fish reproduction by reducing female fertility.

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“…Environmental, occupational, medicinal or xenoestrogenic chemicals can adversely affect the female reproductive system (Gore et al, 2015; Hoyer & Keating, 2014; Neff & Flaws, 2021) and are designated as ovotoxicants. All stages of follicular development can be ovotoxicant targets, leading to harmful effects on follicle development, decreased oocyte quality and ovulation, disruption of the estrous/menstrual cycle and altered hormone production (Hoyer & Keating, 2014).…”

Section: Ovarian Toxicitymentioning

confidence: 99%

Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine

González-Alvarez

Roach

Keating

2023

Molecular Reproduction Devel

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Exposure to environmental toxicants and hyperthermia can hamper reproduction in female mammals including swine. Phenotypic manifestations include poor quality oocytes, endocrine disruption, infertility, lengthened time to conceive, pregnancy loss, and embryonic defects. The ovary has the capacity for toxicant biotransformation, regulated in part by the phosphatidylinositol‐3 kinase signaling pathway. The impacts of exposure to mycotoxins and pesticides on swine reproduction and the potential for an emerging chemical class of concern, the per‐ and polyfluoroalkylated substances, to hamper porcine reproduction are reviewed. The negative impairments of heat stress (HS) on swine reproductive outcomes are also described and the cumulative effect of environmental exposures, such as HS, when present in conjunction with a toxicant is considered.

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The effects of plasticizers on the ovary

Cited by 11 publications

References 49 publications

Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary

Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine

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