In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Oliveira, Vanessa Staldoni de; Marins, Katiuska; Mendes, Ana Karla Bittecourt; Zamoner, Ariane; Leite, Gabriel Adan Araújo; Silva, Fátima Regina Mena Barreto

doi:10.1002/jat.4425

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…Outro estudo focado nos efeitos do piriproxifeno no sistema genital diz respeito ao ciclo ovariano no peixe Danio rerio (Oliveira et al, 2023) Os resultados obtidos pelos autores evidenciaram o ataque oxidativo promovido pelo praguicida. A baixíssima concentração de 10 -⁹ M de piriproxifeno utilizada foi responsável por gerar um aumento da atresia (degeneração do folículo ovariano) nas fêmeas expostas ao praguicida (Oliveira et al, 2023). Dessa forma, foram evidenciados mais uma vez os efeitos prejudiciais do composto em questão, nesse caso mediado por dano oxidativo, reduzindo a fertilidade dos peixes utilizados no estudo.…”

Section: Efeito Do Piriproxifeno No Sistema Genitalunclassified

Emergentes ambientais: alerta à proteção da saúde

2024

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Section: Efeito Do Piriproxifeno No Sistema Genitalunclassified

Emergentes ambientais: alerta à proteção da saúde

2024

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“…These effects include a reduced proportion of mature spermatozoa and spermatids [47]. Moreover, there is a decrease in the proportion of vitellogenin oocytes, coupled with an increased occurrence of atretic follicles, indicating a disruption in the normal ovarian follicle development process [48].…”

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confidence: 99%

Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives

Axel Elizalde-Velázquez,

Elizabeth Herrera-Vázquez

2023

Zebrafish Research - An Ever-Expanding Experimental Model

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Assessing the welfare of aquatic ecosystems has gained immense importance within the scientific community, elevating ecotoxicology to a fundamental discipline. This field utilizes bioindicators, often referred to as model organisms, to investigate the harmful effects of environmental pollution. Amid this array of biological markers, the zebrafish stands out as an exceptional contender. The primary objective of this present investigation is to highlight the complete information available in the literature about the utilization of zebrafish in ecotoxicology. Zebrafish are commonly utilized in research to study reproductive and embryonic toxicity due to their intricate sex-determination mechanism, which is significantly impacted by environmental factors. Similarly, this particular fish species is also employed in studying neuronal signaling, behavior, and DNA damage from pollutants due to their susceptibility and swimming abilities around day five post-fertilization. In addition to the established methodologies, recent advancements in environmental toxicology have incorporated zebrafish into emerging genome editing techniques. These innovative approaches provide fresh and compelling avenues for exploring detoxification mechanisms and organisms’ intricate adaptive responses to environmental stressors. In conclusion, zebrafish are important as model organisms, providing profound insights into diverse facets of ecotoxicological investigations. Furthermore, their relevance is further underscored by their adaptability to evolving genome editing technologies.

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Female Mice Exposed to Pyriproxyfen Since Prepuberty Showed Reproductive Impairment During Sexual Maturity and Increased Fetal Death in Their Offspring

da Silva,

de Mello,

Fagá

et al. 2024

Environmental Toxicology

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Pyriproxyfen (PPF) is an insecticide used in agriculture, which is approved for use in drinking water tanks for human consumption. However, some studies indicate that it may act as an endocrine disruptor and affect nontarget organisms. This study aimed to evaluate the effects of PPF on reproduction and general health status in female mice exposed from pre‐puberty to adulthood. In the first experiment, females were treated by gavage from postnatal day (PND) 23 to (PND) 75 and were distributed into three experimental groups: control (vehicle), PPF 0.1 mg/kg, and PPF 1 mg/kg. Female mice were assessed for the age of puberty onset, body mass, water and food consumption, and the estrous cycle. On PDN 75, a subgroup was euthanized, when vital and reproductive organs were collected and weighed. The thyroid, ovary, and uterus were evaluated for histomorphometry. The other subgroup was assessed in relation to reproductive performance and fetal parameters. In a second experiment, the uterotrophic assay was performed with juvenile females (PND 18) using doses of 0.01, 0.1, or 1 mg/kg of PPF. PPF treatment reduced thyroid mass and increased liver mass. Furthermore, there was an increase in ovarian interstitial tissue and, in the uterus, a decrease in the thickness of the endometrial stroma with reduced content of collagen fibers. There was also a reduction of 30% in pregnancy rate in the treated groups and an increase in the frequency of fetal death. This study suggests that, based on this experimental model, the insecticide may pose a reproductive risk for females chronically exposed to the substance from the pre‐pubertal period until adulthood. These results raise concerns about prolonged exposure of women to the same compound.

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In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Cited by 7 publications

References 42 publications

Emergentes ambientais: alerta à proteção da saúde

Emergentes ambientais: alerta à proteção da saúde

Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives

Female Mice Exposed to Pyriproxyfen Since Prepuberty Showed Reproductive Impairment During Sexual Maturity and Increased Fetal Death in Their Offspring

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