The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action

Kokubo, Takeshi; Komano, Yuta; Tsuji, Ryohei; Fujiwara, Daisuke; Fujii, Toshio; Kanauchi, Osamu

doi:10.1123/ijsnem.2018-0377

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…paracasei 8700:2 in healthy individuals reduced the risk of acquiring common cold infections and pharyngeal symptoms (Berggren et al 2011). A study conducted by Kokubo et al (2019) showed Lactococcus lactis LC plasma affects plasmacytoid dendritic cell activation. This attenuates muscle degenerative genes and the concentration of fatigue-controlled cytokine transforming β-growth factor.…”

Section: Probiotics and Control Of Viral Infectionsmentioning

confidence: 99%

“…Lb. rhamnosus M21 upon treatment for pneumonia in mice showed increased levels of interferon-γ and interleukin-2, which are representative cytokines of type I helper T cells (Song et al 2016) Lactobacillus plantarum Gastroenteritis coronavirus (TGEV) Diminishes granulocyte, reduces virus recovery Yang et al 2017 Lactococcus lactis JCM 5805 RTI, common infectious disease Activates plasmacytoid dendrtitic cell Kokubo et al 2019 Lactobacillus plantarum CRL1506 Gastroenteritis coronavirus (TGEV) Diminish inflammatory-mediated tissue damage Yang et al 2017 Bacillus subtilis OKB105 Gastroenteritis coronavirus (TGEV) Inhibits viral adherence by competitive inhibition Wang et al 2017 ( Table 1). Application of probiotics has demonstrated clinical potential in animal experiments.…”

Section: Probiotics and Control Of Viral Infectionsmentioning

confidence: 99%

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Role of probiotics to combat viral infections with emphasis on COVID-19

Sundararaman

Ray

Ravindra

et al. 2020

Appl Microbiol Biotechnol

145

121

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Interspecies transmissions of viruses between animals and humans may result in unpredictable pathogenic potential and new transmissible diseases. This mechanism has recently been exemplified by the discovery of new pathogenic viruses, such as the novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic, Middle-East respiratory syndromecoronavirus epidemic in Saudi Arabia, and the deadly outbreak of Ebola in West Africa. The. SARS-CoV-2 causes coronavirus disease-19 (COVID-19), which is having a massive global impact in terms of economic disruption, and, above all, human health. The disease is characterized by dry cough, fever, fatigue, myalgia, and dyspnea. Other symptoms include headache, sore throat, rhinorrhea, and gastrointestinal disorders. Pneumonia appears to be the most common and severe manifestation of the infection. Currently, there is no vaccine or specific drug for COVID-19. Further, the development of new antiviral requires a considerable length of time and effort for drug design and validation. Therefore, repurposing the use of natural compounds can provide alternatives and can support therapy against COVID-19. In this review, we comprehensively discuss the prophylactic and supportive therapeutic role of probiotics for the management of COVID-19. In addition, the unique role of probiotics to modulate the gut microbe and assert gut homeostasis and production of interferon as an antiviral mechanism is described. Further, the regulatory role of probiotics on gut-lung axis and mucosal immune system for the potential antiviral mechanisms is reviewed and discussed. Key points • Gut microbiota role in antiviral diseases • Factors influencing the antiviral mechanism • Probiotics and Covid-19

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Section: Probiotics and Control Of Viral Infectionsmentioning

confidence: 99%

Section: Probiotics and Control Of Viral Infectionsmentioning

confidence: 99%

Role of probiotics to combat viral infections with emphasis on COVID-19

Sundararaman

Ray

Ravindra

et al. 2020

Appl Microbiol Biotechnol

145

121

View full text Add to dashboard Cite

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“…Furthermore, the bacterial strain decreased fatigue accumulation during consecutive high intensity exercise. A later study in mice showed that LC-Plasma-activation of pDC in turn attenuates the concentration of fatigue controlled cytokine TGF-β and muscle degenerative genes [154]. Consumption of a probiotic powder containing L. rhamnosus GG and Bif.…”

Section: Impact Of Environment and Life Stage On Gut Microbiota Anmentioning

confidence: 99%

Precision Nutrition and the Microbiome Part II: Potential Opportunities and Pathways to Commercialisation

et al. 2019

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Modulation of the human gut microbiota through probiotics, prebiotics and dietary fibre are recognised strategies to improve health and prevent disease. Yet we are only beginning to understand the impact of these interventions on the gut microbiota and the physiological consequences for the human host, thus forging the way towards evidence-based scientific validation. However, in many studies a percentage of participants can be defined as ‘non-responders’ and scientists are beginning to unravel what differentiates these from ‘responders;’ and it is now clear that an individual’s baseline microbiota can influence an individual’s response. Thus, microbiome composition can potentially serve as a biomarker to predict responsiveness to interventions, diets and dietary components enabling greater opportunities for its use towards disease prevention and health promotion. In Part I of this two-part review, we reviewed the current state of the science in terms of the gut microbiota and the role of diet and dietary components in shaping it and subsequent consequences for human health. In Part II, we examine the efficacy of gut-microbiota modulating therapies at different life stages and their potential to aid in the management of undernutrition and overnutrition. Given the significance of an individual’s gut microbiota, we investigate the feasibility of microbiome testing and we discuss guidelines for evaluating the scientific validity of evidence for providing personalised microbiome-based dietary advice. Overall, this review highlights the potential value of the microbiome to prevent disease and maintain or promote health and in doing so, paves the pathway towards commercialisation.

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“…Это указывает на то, что противовирусный механизм действия пробиотиков может быть независимым от TLR [68]. Исследование, проведенное T. Kokubo et al, показало, что Lactococcus lactis LC влияют на активацию плазмоцитоидных дендритных клеток [78]. Это ослабляет гены дегенерации и концентрацию контролируемого цитокина, трансформирующего β-фактор роста.…”

Section: пробиотики обладают противовирусной активностьюunclassified

Immunomodulatory effects of probiotics

Plotnikova

Zakharova

2020

Medicinskij sovet

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Today, there is an explosion of discoveries related to a growing understanding of the role of microbial communities, key species of bacteria, products or metabolites derived from commensals, and in particular the relationship between some of these components and painful conditions in humans. Microbiota plays a fundamental role in the induction, training and functioning of the host’s immune system. In turn, the immune system has evolved significantly as a means of maintaining the host’s symbiotic relations with these very diverse and developing microbes. At optimal performance, this alliance of the immune system and microbiota allows to induce protective reactions to pathogens and maintain regulatory pathways involved in maintaining tolerance to harmless antigens. In this review, we outline the role of the intestinal microbiota in the immune system, starting with initial information supporting further insights into the effects of intestinal microbiota dysbacteriosis on the host’s susceptibility to infection. Probiotics are considered a good form of therapy to control harmful intestinal microorganisms, improve digestion and the absorption of nutrients. The beneficial effects of probiotics have been demonstrated in many diseases. One of the main mechanisms of probiotics is the regulation of the immune response of the host. The article reviews and discusses the regulatory role of probiotics in the “intestine-lungs” system and the immune system of mucous membranes for potential antiviral mechanisms. The unique role of probiotics in modulation of intestinal microbes and establishment of intestinal homeostasis and production of interferon as antiviral mechanism is described. In addition, the regulatory role of probiotics in the system «intestine-lungs» and the immune system of the mucous membranes for potential antiviral mechanisms, including in COVID-19 is considered and discussed. Symbiotic products Bac-Set® Forte and Bac-Set® Cold/Flu are described.

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The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action

Cited by 10 publications

References 24 publications

Role of probiotics to combat viral infections with emphasis on COVID-19

Role of probiotics to combat viral infections with emphasis on COVID-19

Precision Nutrition and the Microbiome Part II: Potential Opportunities and Pathways to Commercialisation

Immunomodulatory effects of probiotics

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