The effects of phytoestrogens on bone

Anderson, John J.B.; Garner, Sanford C.

doi:10.1016/s0271-5317(97)00156-5

Cited by 141 publications

(88 citation statements)

References 25 publications

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“…31,32) Both in vitro and in vivo studies have shown that genistein exerts a weak estrogenic effect: 10 À3 to 10 À5 -fold that of estrogen. 1,33) It was recently reported also that genistein induced uterine hypertrophy only at doses more than 10-fold higher than the dose needed to prevent bone loss in OVX mice. 34) According to our results, isoflavone extract from soybean hypocotyls was able to prevent OVX-induced bone loss without exhibiting estrogenic action in the uterus of OVX rats at a dosage of 10.67 mg/day (comprising 1.27 mg of genistein derivatives, 5.58 mg of daidzein derivatives, and 3.82 mg of glycitein derivatives).…”

Section: Discussionmentioning

confidence: 99%

“…1) Nutritional and pharmacological strategies are necessary to prevent age-related bone loss. Ovarian hormone deficiency is a major risk factor for osteoporosis.…”

mentioning

confidence: 99%

“…8,9) Epidemiological studies suggest that the low incidence of osteoporosis and heart disease in postmenopausal Asian women compared to American women is attributable to their higher intake of soybean-based foods. 1,10) Kalu et al 11) observed that feeding soy protein instead of casein to elderly rats prevented agerelated bone loss. This positive effect of soy protein on bone was ascribed to its amino acid composition.…”

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confidence: 99%

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Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

Lee

Kim

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

“…1) Nutritional and pharmacological strategies are necessary to prevent age-related bone loss. Ovarian hormone deficiency is a major risk factor for osteoporosis.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

Lee

Kim

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…ERb may play a dual role: as a competitor of ERa at normal or low E 2 levels and as an alternative for ERa, inhibiting bone turnover and preventing bone loss in the presence of high E 2 levels (Sims et al 2002). The preferential affinity of daidzein and 4-MBC to ERb (Anderson & Garner 1997, Schlumpf et al 2004) and altered hormonal status in Ovx rats may influence the responses of skeleton. Furthermore, BW and body fat composition are mainly influenced by ERa-specific signaling (Ohlsson et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Soy is the major source of phytoestrogens in the human diet. They have estrogenic effect when combining with estrogen receptors (ERs) with preference for ERb, however, at much lower affinities than estradiol-17b-benzoate (E 2 ; Anderson & Garner 1997). In people consuming high amounts of phytoestrogens, lower rates of cardiovascular disease, breast, prostate and colon cancer, menopausal symptoms, and osteoporosis have been documented.…”

Section: Introductionmentioning

confidence: 99%

Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

Komrakova¹,

Sehmisch²,

Tezval³

et al. 2011

Journal of Endocrinology

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The study investigated the influence of 4-methylbenzylidene camphor (4-MBC), daidzein, and estradiol-17b-benzoate (E 2 ) on either intact or osteotomized cancellous bone in ovariectomized (Ovx) rats. Three-month old Ovx rats were fed with soy-free (SF) diet over 8 weeks; thereafter, bilateral transverse metaphyseal osteotomy of tibia was performed and rats were divided into groups: rats fed with SF diet and SF diet supplemented with 4-MBC (200 mg), daidzein (50 mg), or E 2 (0 . 4 mg) per kilogram body weight. After 5 or 10 weeks, computed tomographical, biomechanical, histological, and ashing analyses were performed in lumbar spine and tibia of 12 rats from each group. 4-MBC and E 2 improved bone parameters in lumbar spine and tibia, were not favorable for osteotomy healing, and decreased serum osteocalcin level. However, daidzein improved bone parameters to a lesser extent and facilitated osteotomy healing. For lumbar spine, the bone mineral density was 338G9, 346G5, 361G6, and 360G5 mg/cm 3 in SF, daidzein, 4-MBC, and E 2 , respectively, after 10 weeks. For tibia, the yield load was 98G5, 114G3, 90G2, and 52G4 N in SF, daidzein, 4-MBC, and E 2 , respectively, after 10 weeks. Serum daidzein was 54G6 ng/ml in daidzein group and equol was not detected. Alp and Igf1 genes were down-regulated in callus after daidzein and E 2 compared with 4-MBC (week 5). The response of bone tissue and serum markers of bone metabolism could be ordered: daidzein!4-MBC!E 2 . Treatments were more effective after 5 vs 10 weeks. In SF group, bone structure was impaired after 5 weeks and improved after 10 weeks probably due to adaptation mechanisms to osteoporosis. In conclusion, it is conceivable that 4-MBC may improve bone tissue in osteoporotic organisms; osteoporotic patients with fractures could benefit from daidzein treatment.

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The chemistry and biological activity of herbs used in Flor-Essence? herbal tonic and Essiac

Tamayo¹,

Richardson²,

Diamond³

et al. 2000

Phytother. Res.

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The herbal mixtures, Essiac™ and Flor‐Essence™, are sold as nutritional supplements and used by patients to treat chronic conditions, particularly cancer. Evidence of anticancer activity for the herbal teas is limited to anecdotal reports recorded for some 40 years in Canada. Individual case reports suggest that the tea improves quality of life, alleviates pain, and in some cases, impacts cancer progression among cancer patients. Experimental studies with individual herbs have shown evidence of biological activity including antioxidant, antioestrogenic, immunostimulant, antitumour, and antiocholeretic actions. However, research that demonstrates these positive effects in the experimental setting has not been translated to the clinical arena. Currently, no clinical studies of Essiac™ or Flor‐essence™ are published, but a clinical study is being planned at the British Columbia Cancer Agency by the University of Texas‐Center for Alternative Medicine (UT‐CAM) and Tzu‐Chi Institute for Complementary and Alternative Medicine. Copyright © 2000 John Wiley & Sons, Ltd.

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The effects of phytoestrogens on bone

Cited by 141 publications

References 25 publications

Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

Evaluation of the Preventive Effect of Isoflavone Extract on Bone Loss in Ovariectomized Rats

Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats

The chemistry and biological activity of herbs used in Flor-Essence? herbal tonic and Essiac

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