The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease

Ciobîcă, Alin; Olteanu, Zenovia; Pădurariu, Manuela; Hrițcu, Lucian

doi:10.1007/s13105-011-0119-x

Cited by 37 publications

(23 citation statements)

References 53 publications

(69 reference statements)

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“…Oxidative stress is the condition arising from the imbalance between toxic reactive oxygen species (ROS) and antioxidant systems (5), being also recognized as a very important mechanism in a variety of pathologies (6) including neuropsychiatric disorders, as our group has previously demonstrated (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Alexinschi¹,

Chiriță²,

Ciobîcă³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackground: Although it is generally accepted that there is an increased oxidative stress status in alcoholics, the separate relevance of oxidative stress following alcohol withdrawal is still not understood to this date. There are reports stating that the increased oxidative stress status in alcoholics may persist independently of the constant presence of alcohol intake, while on the other side, it was demonstrated that the antioxidant defense mechanism could significantly increase after alcohol withdrawal. Methods: In the present work, we were interested in studying the relevance of oxidative stress status in the alcohol withdrawal processes, by determining some oxidative stress markers (two antioxidant enzymes: superoxide dismutase -SOD and glutathione peroxidase -GPX and a lipid peroxidation maker -MDA) after one week and one month of abstinence, as compared to the baseline and a control group of subjects. Results: Our data confirmed the increased oxidative stress status in alcoholic patients and, more importantly, we de monstrated here a significant decrease of the oxidative stress status one week and one month following the withdrawal, as showed by a significant increase in the specific activity of

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Section: Introductionmentioning

confidence: 99%

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Alexinschi¹,

Chiriță²,

Ciobîcă³

et al. 2014

Journal of Medical Biochemistry

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“…Nicotine administration in these rats showed a convincing improvement in the short-term memory, as examined on the Y-maze task and the shuttle-box task having a decreased number of escape failures, and an increased number of conditioned avoidance responses [121]. In a similar study, pergolide, a DA agonist, improves spatial memory in a rat model of PD [122].…”

Section: Neuropsychological Dysfunctionmentioning

confidence: 99%

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

Sayana

Jankovic

2014

Neurotherapeutics

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Parkinson's disease (PD) is a progressive, neurodegenerative disorder of unknown etiology, although a complex interaction between environmental and genetic factors has been implicated as a pathogenic mechanism of selected neuronal loss. A better understanding of the etiology, pathogenesis, and molecular mechanisms underlying the disease process may be gained from research on animal models. While cell and tissue models are helpful in unraveling involved molecular pathways, animal models are much better suited to study the pathogenesis and potential treatment strategies. The animal models most relevant to PD include those generated by neurotoxic chemicals that selectively disrupt the catecholaminergic system such as 6-hydroxydopamine; 1-methyl-1,2,3,6-tetrahydropiridine; agricultural pesticide toxins, such as rotenone and paraquat; the ubiquitin proteasome system inhibitors; inflammatory modulators; and several genetically manipulated models, such as α-synuclein, DJ-1, PINK1, Parkin, and leucine-rich repeat kinase 2 transgenic or knock-out animals. Genetic and nongenetic animal models have their own unique advantages and limitations, which must be considered when they are employed in the study of pathogenesis or treatment approaches. This review provides a summary and a critical review of our current knowledge about various in vivo models of PD used to test novel therapeutic strategies.

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“…Afterward, samples were centrifuged at 3000 rpm for 10 min and supernatant was read at 532 nm. The signal was read against an MDA standard curve, and the results were expressed as nmol/ml [20,21].…”

Section: Determination Of Malondialdehydementioning

confidence: 99%

Increased oxidative stress status in rat serum after five minutes treadmill exercise

Trofin

Ciobîcă²,

Cojocaru

et al. 2014

Open Medicine

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AbstractAlthough it is accepted that an important correlation exists between the physical exercise and the oxidative stress status, the data regarding the levels of the main oxidative stress markers after physical training have been difficult to interpret and a subject of many controversies. There are also very few studies regarding the effects of short-time exercise on the oxidative stress status modifications. Thus, in the present report we were interested in studying the modifications of some oxidative stress markers (two antioxidant enzymes-superoxide dismutase and glutathione peroxidase, a lipid peroxidation parameter — malondyaldehide, the total antioxidant status and protein carbonyl levels), from the serum of rats that were subject to one bout of five minutes exercise on a treadmill, when compared to a control sedentary group. In this way, we observed a decrease of superoxide dismutase specific activity in the rats which performed the exercises. Still, no modifications of glutathione peroxidase specific activity were found between groups. In addition, increased levels of malondyaldehide and protein carbonyls were observed in the rats subjected to exercises. In conclusion, our data provides new evidence regarding the increase of the oxidative stress status, as a result of a 5-minutes bout of treadmill exercising in rats, expressed through a decrease in the SOD specific activity and the total antioxidant status and also an increase of the lipid peroxidation and protein oxidation processes.

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The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease

Cited by 37 publications

References 53 publications

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Animal Models of Parkinson's Disease: A Gateway to Therapeutics?

Increased oxidative stress status in rat serum after five minutes treadmill exercise

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