The effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory, and learning in rats

Erdoğan, Füsun; Gölgeli, Asuman; Arman, Fehim; Ersoy, Ali Özdemir

doi:10.1016/j.yebeh.2004.03.001

Cited by 41 publications

(27 citation statements)

References 36 publications

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“…In agreement with previous work [37], SE induced deficits in spatial learning and memory. Experimentally induced seizures can lead to postictal impairment of learning [38].…”

Section: Discussionsupporting

confidence: 93%

Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats

2007

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Status epilepticus (SE) is associated with a significant risk of cognitive impairment, and the increase of nitric oxide (NO) releasing has been reported during SE. We investigated the effects of neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI) and inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on spatial performance of rats in the Morris water maze. Treatment with 7-NI, but not with AG, improved the performance of rats after SE not only in acquisition of the task but also in probe test. Furthermore, the level of SE-induced malondialdehyde (MDA), end product of lipid peroxidation, was significantly decreased only in animals receiving 7-NI injection. Taken together, the results of the present study provided evidence that the NO pathway contributed to oxidative stress after SE, and nNOS/NO pathway may underlie one of the potential mechanisms contributing to SE-induced spatial memory deficits.

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“…In agreement with previous work [37], SE induced deficits in spatial learning and memory. Experimentally induced seizures can lead to postictal impairment of learning [38].…”

Section: Discussionsupporting

confidence: 93%

Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats

2007

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“…Surgical interventions for EEG recording are performed under anesthesia (ketamine, 100 mg/kg, ip and xylazine 20 mg/kg ip). [32] Animals are placed in the stereotaxic frame. [33] By the guidance of stereotaxic atlas, electrodes are placed into the intended coordinates.…”

Section: Number Of Animalsmentioning

confidence: 99%

“…[29] They are fixed with screw, covered with cold acrylic and sculp is sutured. [32] Following the surgery, 1 week is passed for healing of local effects of surgery and anesthesia before monitoring procedure. [33] Action mechanism of PTZ PTZ is a selective antagonist of receptor of GABAA chloride ionophore complex.…”

Section: Number Of Animalsmentioning

confidence: 99%

Pentylenetetrazol Kindling Epilepsy Model

Erkeç¹,

Arıhan²

2015

Epilepsi

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SummaryEpilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy. Basic mechanisms of epilepsy have not entirely been clarified yet. Using seizure and epilepsy animal models, our comprehension about basic mechanisms underlying epileptogenesis has improved. In addition, animal models of epilepsy and seizures are very useful in the discovery and development of new antiepileptic drugs. Pentylenetetrazole (PTZ) is widely used in antiepileptic drug discovery studies, and PTZ kindling model is very important to understand the pathophysiology of epilepsy. In this review, current information about PTZ kindling model was given in this aspect.Key words: Chemical kindling; epilepsy; experimental animal models; pentylenetetrazole; rat. ÖzetEpilepsi genel popülasyonun yaklaşık %1'ini etkileyen en yaygın nörolojik düzensizliklerden biridir. Antiepileptik ilaç tedavisi gören hastaların üçte birinde hiçbir hafifleme elde edilememektedir. Epilepsi için kullanılan güncel tedaviler semptomatiktir ve antiepileptik etkiden ziyade anti nöbet etkilidir. Bu tedaviler epilepsiyi tedavi etmemektedir. Epilepsinin temel mekanizmaları da henüz tam olarak anlaşılamamıştır. Nö-bet ve epilepsi hayvan modelleri kullanılarak epilepsinin temelinde yatan mekanizmaları kavrayışımız ilerlemektedir. Ayrıca epilepsi ve nöbet hayvan modelleri yeni antiepileptik ilaç keşfi ve gelişimi bakımından kullanışlıdırlar. Pentilentetrazol (PTZ), antiepileptik ilaç keşif çalışmala-rında yaygın biçimde kullanılmaktadır ve PTZ tutuşma modeli epilepsinin patofizyolojisinin anlaşılması bakımından oldukça önemlidir. Bu

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“…However, Erdoğan et al have demonstrated impaired fear-related memory in rats one and two weeks after PTZ-induced seizures [89]. Later, Assaf et al further supported these findings by the demonstration of spatial and object memory deficits in mice that experienced episodes of PTZ-induced convulsions 3-5 weeks earlier [90].…”

Section: Single Seizure and Cognition: Clinical And Translational Impmentioning

confidence: 98%

Single Seizure and Cognition: Clinical and Translational Implications

2016

ARC Journal of Neuroscience

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The effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory, and learning in rats

Cited by 41 publications

References 36 publications

Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats

Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats

Pentylenetetrazol Kindling Epilepsy Model

Single Seizure and Cognition: Clinical and Translational Implications

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