The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism

Hepşen, Sema; Akhanli, Pınar; Sakiz, Damlanur; Sencar, Muhammed Erkam; Uçan, Bekir; Ünsal, İlknur Öztürk; Çakal, Erman

doi:10.1007/s11657-020-00759-8

Cited by 11 publications

(14 citation statements)

References 27 publications

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“…Sikjaer et al [30] evaluated patients using the SF-36 and found lower QOL scores among 22 hypoparathyroid patients receiving conventional therapy compared with 22 healthy controls. Similarly, Hepsen et al [28] found lower SF-36 QOL scores in hypoparathyroid patients receiving conventional therapy (n = 160) compared with controls (n = 148). In their multinational survey, Siggelkow et al [31] reported that the disease could not be controlled despite conventional treatment in hypoparathyroid patients (n = 398) and this negatively influenced QOL variables.…”

Section: Discussionmentioning

confidence: 85%

“…However, the two patient groups did not differ significantly in terms of QOL scores. Hepsen et al [28] determined that patients with nonsurgical hypoparathyroidism had better mental health and vitality scores than patients with postsurgical hypoparathyroidism. In our study, we noted no difference in QOL scores by aetiology of disease (surgery, autoimmune, and thyroid cancer).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients

Anaforoğlu

Sancak

Akbaş

et al. 2021

Exp Clin Endocrinol Diabetes

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Objectives This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life. Study design Prospective, multicentre study. Methods Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. They were receiving conventional therapies for hypoparathyroidism, using calcium, active vitamin D, and magnesium. We collected data on demographic features, disease- and treatment-related information, and results of routine laboratory tests, treatment adherence, and presence of complications. Beck Depression Inventory, Beck Anxiety Inventory, and Short Form-36 quality of life assessments were administered. Results Among the 300 patients studied, 60.7% were adherent to their treatment, and 34.1% had complications. Anxiety and depression scores were significantly higher in non-adherent versus treatment-adherent patients (p<0.001 and p=0.001, respectively). Most of the domains of quality-of-life scores were also significantly lower in non-adherent patients. Both anxiety and depression scores showed significant, negative correlations with serum calcium and magnesium concentrations (r=−0.336, p<0.001 and r=−0.258, p<0.001, respectively). Conclusions Nearly 40% of the patients were non-adherent to conventional treatment for hypoparathyroidism, and such patients had higher anxiety and depression scores and poorer quality of life scores. Conventional treatment might not be sufficient to meet the needs of patients with hypoparathyroidism. In addition to seeking new therapeutic options, factors influencing quality of life should also be investigated and strategies to improve treatment adherence should be developed.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients

Anaforoğlu

Sancak

Akbaş

et al. 2021

Exp Clin Endocrinol Diabetes

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“…Third, less than 50% of the patients were able to provide laboratory parameters and comorbidities were not assessed, making it impossible to include these in the analysis. Studies have shown that QOL does not correlate directly with laboratory results 11,21,25,26 and the influence of comorbidities is discussed controversially 9,21 . Our study was a voluntarily online survey which might lead to an inclusion of patients with more severe problems since they are severely affected, but since patients were also recruited through their treating physician we could ensure that the sample was drawn from a representative population.…”

Section: Discussionmentioning

confidence: 99%

“…9 Therapies and blood level parameters might play a role in influencing QOL in hy-poPT patients, but the role of blood levels results in particular is conflicting in the literature. 4,9,11 The severity of symptoms and therefore their influence on QOL cannot be directly translated to serum calcium levels, 1 since calcium levels may vary throughout the day and therefore single measures might not explain effects on QOL. 13 Factors like symptoms, disease duration, aetiology of hypoPT, or sociodemographic factors may play an important role in the QOL of hypoPT patients.…”

Section: Introductionmentioning

confidence: 99%

What are predictors of impaired quality of life in patients with hypoparathyroidism?

Büttner

Krogh

Siggelkow

et al. 2022

Clinical Endocrinology

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Context Hypoparathyroidism (hypoPT) is a rare endocrine disorder. Little is known about what factors are associated with potential quality of life (QOL) impairments. Design HypoPT patients at a minimum of 6 months' post diagnosis were invited to participate in an online survey through their treating physician or through self‐help organisations Methods Impairments of clinical importance in QOL were considered present if the score of the respective functioning scale of the European Organization for Research and Treatment of Cancer (EORTC) QLQ‐C30 exceeded a pre‐defined threshold. Symptom burden was assessed using the HPQ‐28. Multivariate logistic regression was used to identify factors associated with impairments in QOL. Results Data were available for 264 hypoPT patients. Impairments of clinical importance in QOL were reported for 40.4% in role functioning (RF), 40.6% in social functioning (SF), 60.8% in physical functioning (PF), 65.5% in cognitive functioning (CF) and 76.0% in emotional functioning (EF). Higher odds for reporting impaired QOL were seen for higher symptom burden (for almost all domains) and for being unable to work (for PF, RF and SF). Surgery for thyroid cancer being the cause of hypoPT was associated with lower odds in PF for patients and in PF and CF for patients with surgery for other thyroid‐related diseases being the hypoPT cause. Conclusions HypoPT needs to be recognised as a disease which might be associated with impaired QOL and affect daily living. Symptom management is crucial for improving QOL in hypoPT patients but socioeconomic factors like work‐ability need to be considered when treating hypoPT patients.

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“…The control group included 24 patients without PS-HypoPT, mainly females (n = 21, 83.3%) with a median age of 53 (41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58) years and a median duration of the disease 9.5 years (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Patientsmentioning

confidence: 99%

Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism

Saponaro

Alfì

Cetani

et al. 2022

J Endocrinol Invest

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Purpose Hypoparathyroidism (HypoPT) is a rare endocrine disease and conventional therapy is based on calcium and vitamin D analogues. Conventional therapy does not restore calcium homeostasis and patients complain with neuropsychological symptoms, which have been evaluated with nonspecific self-administered questionnaires. This study aims to evaluate cognitive functions of patients with chronic post-surgical (PS)-HypoPT compared to a control population, using a standardized neuropsychological approach and evaluating the relationship with serum calcium (Alb-Ca). Methods Observational, monocentric study on 33 patients with PS-HypoPT and 24 controls, in whom biochemical testing and a standardized neuropsychological assessment by a trained psychologist were performed. Results In patients with PS-HypoPT, low Alb-Ca correlated with a worse performance on semantic memory abilities and executive function, as suggested by a significant inverse correlation between Alb-Ca and Trail Making Test A (TMT-A) scores (r = − 0.423; p = 0.014) and by a positive correlation with Semantic Fluency Test scores (SF)(r = 0.510; p = 0.002). PS-HypoPT patients with Alb-Ca ≤ 8.9 mg/dl had a significantly lower test performance compared with PS-HypoPT patients with Alb-Ca > 8.9 mg/dl, both at the TMT-A test (mean score: 34.53–18.55; p < 0.0001) and at SF test (mean score: 41.94–48.68; p = 0.01) and also a significantly lower test performance compared with control patients’ group at TMT-A (mean score: 34.53–25.5; p = 0.0057). Conclusions Patients with chronic PS-HypoPT in conventional therapy do not show a severe cognitive impairment; however, cognitive functions namely visuo-spatial attention, executive function and semantic memory appear to be modulated by Alb-Ca and impaired by its low levels.

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The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism

Cited by 11 publications

References 27 publications

Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients

Effects of Treatment Adherence on Quality of Life in Hypoparathyroid Patients

What are predictors of impaired quality of life in patients with hypoparathyroidism?

Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism

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