The effects of ozone application on genotoxic damage and wound healing in bisphosphonate-applied human gingival fibroblast cells

Akdeniz, Sıdıka Sinem; Beyler, Esra; Korkmaz, Yonca; Yurtçu, Erkan; Ateş, Ufuk; Araz, Kenan; Şahin, Feride İffet; Torun, O Y

doi:10.1007/s00784-017-2163-6

Cited by 31 publications

(40 citation statements)

References 32 publications

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“…Many fields in dentistry have used OT to exploit the advantages of ozone, particularly its effects on wound healing and antimicrobial properties (Akdeniz et al, ; Alpan, Toker, & Ozer, ; Ozdemir, Toker, Balcı, & Ozer, ; Taşdemir, Taşdemir et al, ; Yılmaz et al, ). A few studies (Al Habashneh, Alsalman, & Khader, ; Yılmaz et al, ) have examined OT in non‐surgical periodontal therapy, but there has been no split‐mouth study of OT in periodontal therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Ozone has positive effects on oxygen metabolism, the antioxidant defense system, and microcirculation (Ahmedi, Ahmedi, Sejfija, Agani, & Hamiti, ). Many fields in dentistry have sought to exploit the proven advantages of OT (Akdeniz et al, ; Karaca, Ergun, & Ozturk, ; Mostafa & Zakaria, ). The principle of OT is the transformation of environmental diatomic oxygen molecules into ozone on contact with a special probe tip on the treated area (Kazancioglu, Kurklu, & Ezirganli, ; Sacco & Campus, ).…”

Section: Introductionmentioning

confidence: 99%

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The effects of ozone therapy on periodontal therapy: A randomized placebo‐controlled clinical trial

et al. 2019

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Objectives The aim of this randomized split‐mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non‐surgical periodontal therapy. Methods A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL, were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non‐surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin‐3 (PTX‐3), interleukin‐1β (IL‐1β), and high sensitivity C‐reactive protein (Hs‐CRP) were evaluated. All statistical data were analyzed using SPSS software. Results Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5 mm and CAL, and percentage of ≥3 mm CAL were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX‐3, Hs‐CRP, and IL‐1, were reduced at 3‐month follow‐up. Only the decrease in PTX‐3 levels between baseline and 3‐month follow‐up was statistically significant. Conclusions Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX‐3 levels were significantly lower at ozone sites compared to those at the control sites.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of ozone therapy on periodontal therapy: A randomized placebo‐controlled clinical trial

et al. 2019

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“…Ozone (O 3 ), consisting of three oxygen atoms, is a highly unstable gas (depending on conditions such as temperature and pressure), which cannot be stored. This component, as an antimicrobial agent, has high oxidation potential against bacteria, viruses, fungi, and protozoa (18,19). It also stimulates blood circulation and the immune system.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

Nabi

Sedighinejad

Mirbolouk

et al. 2018

Arch Clin Infect Dis

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Background: Treatment of chronic osteomyelitis is complex and includes long-term management with antibiotics and debridement. Inadequate blood supply, underlying diseases, and deep involvement of the infected area can cause classic treatments to fail and lead to serious complications, such as limb amputation. Recently, there has been increasing interest in the use of ozone therapy for infectious diseases. Objectives: This study was designed to investigate the beneficial effects of ozone therapy on chronic osteomyelitis. Methods: Sixty patients with chronic osteomyelitis were divided into two homogenized groups: ozone therapy and control. Ozone therapy at a concentration of 30 mg/mL was performed daily by ozone bagging, minor autohemotherapy, and ozone saline injection into the bone. Data were analyzed to determine recovery and erythrocyte sedimentation rates. Results: The recovery rate was 73.33% in the control group versus 86.66% in the ozone group (P = 0.31). No significant difference was found between the groups regarding the recovery rate (P = 0.86). However, considering the erythrocyte sedimentation rate, the results were significantly superior in the ozone group (P = 0.0001). Conclusions: These findings indicate that ozone therapy, as a promising complementary treatment, can be applied in chronic osteomyelitis management.

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“…A fundamental effect of ozone is improved oxygenation of cells. Furthermore, ozone plasma application activates blood circulation, increases hemoglobin concentration, enhances diapedesis and phagocytosis during inflammatory response, and stimulates all antimicrobial biologic reactions [17]. The reaction of fatty acid peroxidation increases the elasticity of the erythrocyte cell membrane.…”

Section: Introductionmentioning

confidence: 99%

“…The reaction of fatty acid peroxidation increases the elasticity of the erythrocyte cell membrane. Thanks to this, cells pass more easily through the capillaries, which significantly improves the metabolism of tissues [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch—a randomized clinical controlled trial

Matys

Jaszczak²,

Flieger³

et al. 2019

Lasers Med Sci

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The effect of ozone, diode laser irradiation, and presence of teeth crowding/spacing on pain perception in orthodontic patient was tested. Overall, 76 patients [55 women and 21 men; age 35.1(6.4) years] who met the inclusion criteria participated in the study. Immediately after fixed orthodontic appliance placement, the patients were exposed to a pain relief treatment (one single session) using either 635-nm diode laser (SmartM, Lasotronix, Warsaw, Poland) or ozone therapy (OzoneDTA, Apoza, New Taipei City, Taiwan) by placing the handpieces in the area of each teeth apex and interdental papillae, from the maxillary right first molar to the maxillary left first molar. Subjects were divided into three groups: control group (G1, n = 26), ozone (G2, n = 26, exposed to ozone therapy, generator probe type 3, working time per point 5 s, 23 points, application time 1 min and 55 s), and laser group (G3, n = 25, exposed to continuous mode diode laser, 400 mW, handpiece diameter 8 mm, spot area 0.5024 cm 2 , power density per second 1.59 W/cm 2 , dose 2 J per point, time: 5 s per point, 23 points, total energy per session 46 J, application time 1 min and 55 s). The level of teeth crowding was assessed using the Lundstrom indicator. The patients received a questionnaire for pain assessment (the Numeric Rating Scale, NRS-11, grade level 0-10) and recorded at 7 time points (1 h, 6 h, and 1, 2, 3, 4, and 5 days ) after the fixed orthodontic appliance placement. The mean pain values for the diode laser, ozone, and control group were 3.6 (1.31) (95% CI, 2.95-4.25), 5.25 (3.37) (95% CI, 3.52-6.98), and 5.75 (2.40) (95% CI, 4.69-6.81), respectively. We observed lower pain values in the diode laser group compared to the control group (p = 0.0237). The use of ozone in this study did not result in significant pain reduction in comparison to control (p = 0.8040) and laser groups (p = 0.1029). There were no differences in pain perception between patients with crowded teeth and non-crowded teeth in each group (G1, p = 0.66, G2, p = 0.86, G3, p = 0.24). The use of 635-nm diode laser led to decreased pain perception; however, ozone and presence of teeth crowding/spacing did not affect the pain perception in orthodontic patients during the first 5 days after the fixed orthodontic appliance placement.

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The effects of ozone application on genotoxic damage and wound healing in bisphosphonate-applied human gingival fibroblast cells

Abstract: Ozone gas plasma therapy may be helpful in prevention of gingival healing delay in MRONJ pathogenesis especially when applied simultaneously with surgical intervention.

Cited by 31 publications

References 32 publications

The effects of ozone therapy on periodontal therapy: A randomized placebo‐controlled clinical trial

The effects of ozone therapy on periodontal therapy: A randomized placebo‐controlled clinical trial

The Effectiveness of Ozone Therapy in Chronic Osteomyelitis: A Randomized Controlled Clinical Trial

Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch—a randomized clinical controlled trial

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