The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis

Zhang, Rongping; Wu, Runze; Gu, Yanping; Lu, Yibing

doi:10.1016/j.mce.2020.110903

Cited by 29 publications

(53 citation statements)

References 59 publications

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“…Mostly recognized for its potential to induce labour and lactation, oxytocin also stimulate beta cell function, 54 and in obese individuals, exogenous oxytocin has been shown to decrease food intake 55,56 and body weight 57 . In rodents, exogenous oxytocin increases thermogenesis 58,59 and reduces food intake, leading to weight loss 60 . Oxytocin levels are higher in obese compared with lean individuals, and oxytocin levels decrease after the bariatric procedure Roux‐en‐Y gastric bypass (RYGB) 61 .…”

Section: Endocrine Regulators Of Food Intake and Appetite In Humansmentioning

confidence: 99%

An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

Theilade

Christensen

Vilsbøll

et al. 2021

Diabetes Obesity Metabolism

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Obesity is one of the biggest health challenges of the 21st century, already affecting close to 700 million people worldwide, debilitating and shortening lives and costing billions of pounds in healthcare costs and loss of workability. Body weight homeostasis relies on complex biological mechanisms and the development of obesity occurs on a background of genetic susceptibility and an environment promoting increased caloric intake and reduced physical activity. The pathophysiology of common obesity links neuro‐endocrine and metabolic disturbances with behavioural changes, genetics, epigenetics and cultural habits. Also, specific causes of obesity exist, including monogenetic diseases and iatrogenic causes. In this review, we provide an overview of obesity mechanisms in humans with a focus on energy homeostasis, endocrine regulation of food intake and eating behavior, as well as the most common specific causes of obesity.

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Section: Endocrine Regulators Of Food Intake and Appetite In Humansmentioning

confidence: 99%

An overview of obesity mechanisms in humans: Endocrine regulation of food intake, eating behaviour and common determinants of body weight

Theilade

Christensen

Vilsbøll

et al. 2021

Diabetes Obesity Metabolism

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“…Importantly CS increases Oxt expression in skeletal muscle since thermogenesis in skeletal muscle plays an important role for whole body energy. In the Yuan et al [23] study, Oxt infusion has no effect on the reduction of food consumption in diet induced obese mice. The author explained this data set postulating that Oxt regulates thermogenesis.…”

Section: Introductionmentioning

confidence: 89%

“…Previous studies show that deletion of Oxt/Oxtr induces late on-set obesity in mice [15,16] and Oxt administration reduces body weight among different species [65][66][67]. Downstream of these results Yuan et al [23] formulates three possible hypothesis to explain this mechanism. The first explanation seems to be reduced food intake.…”

Section: Yuan Et Al's Theory and Oxytocin Regulation Of Thermogenesis In Skeletal Musclementioning

confidence: 98%

“…Oxt signaling is important for whole-body glucose metabolism and Oxt administration in humans reducing fasting respiratory quotient meaning that Oxt can induce a shift from carbohydrate to fat oxidation [21,22]. Recently, and about 10 years after these first discoveries, three different studies have been published by Yuan et al [23], Sun et al [24], Conte et al [19], each of them presenting a different theory on the role of Oxt in the regulation of energy metabolism and the paradox of normophagic obesity that we first described for Oxt −/− and Oxtr −/− mice [15,16]. Specifically, in Yuan et al [23], the author analyzed the role of Oxt in energy homeostasis after a cold stress (CS) challenge and found that Oxt dissipates stored energy in brown adipose tissue (BAT) and white adipose tissue (WAT) improving metabolic dysfunctions in obese mice.…”

Section: Introductionmentioning

confidence: 99%

“…In this review, we described and compared these three theories by Yuan et al [23], Sun et al [24], and Conte et al [19] on the role of Oxt in body composition and outside of pregnancy with the intent of incorporating them into one complete theory.…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin Involvement in Body Composition Unveils the True Identity of Oxytocin

Camerino

2021

IJMS

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The origin of the Oxytocin/Vasopressin system dates back about 600 million years. Oxytocin (Oxt) together with Vasopressin (VP) regulate a diversity of physiological functions that are important for osmoregulation, reproduction, metabolism, and social behavior. Oxt/VP-like peptides have been identified in several invertebrate species and they are functionally related across the entire animal kingdom. Functional conservation enables future exploitation of invertebrate models to study Oxt’s functions not related to pregnancy and the basic mechanisms of central Oxt/VP signaling. Specifically, Oxt is well known for its effects on uteri contractility and milk ejection as well as on metabolism and energy homeostasis. Moreover, the striking evidence that Oxt is linked to energy regulation is that Oxt- and Oxytocin receptor (Oxtr)-deficient mice show late onset obesity. Interestingly Oxt−/− or Oxtr−/− mice develop weight gain without increasing food intake, suggesting that a lack of Oxt reduce metabolic rate. Oxt is expressed in a diversity of skeletal muscle phenotypes and regulates thermogenesis and bone mass. Oxt may increases skeletal muscle tonicity and/or increases body temperature. In this review, the author compared the three most recent theories on the effects of Oxt on body composition.

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