The Effects of Oxygen Breathing in Patients with Acute Myocardial Infarction

Evidence for Oxygen Use in the Hospitalized Patient: Is More Really the Enemy of Good?

“…[64][65][66] Foster et al found that as P aO 2 increased, so did arterial pressure and systemic vascular resistance. 67 Kenmure et al 68 and Thomas et al 69 found an increase in blood pressure and decrease in cardiac output when patients suffering from a myocardial infarction breathed F IO 2 of 0.4. McNulty et al, using a Doppler flow wire, showed in 18 subjects that coronary vascular resistance increased by 41% and coronary blood flow decreased by 29% when the subjects breathed F IO 2 of 1.0 for 15 min.…”

A systematic review of the effectiveness of oxygen in reducing acute myocardial ischaemia

“…Of the 463 combined patients in the review only 96 (20.7%) were women. There were also 37 patients whose genders were not given: these were in two comparison groups totalling 29 patients (Foster et al. , 1969; Sukumalchantra et al.…”

“…In the majority of trials patients were used as their own controls, so this variable was constant. Detailed sub‐analysis of results based on degree of heart failure is carried out in two trials (Foster et al. , 1969; Sukumalchantra et al.…”

“…, 1996). The length and severity of the systemic hypoxaemia or the general condition of the patient may be determining factors (Foster et al. , 1969; Madias et al.…”

A randomised controlled trial of the effect of high concentration oxygen on myocardial ischaemia during exercise

“…However, there is also substantive evidence to suggest that high concentration oxygen therapy may be harmful when administered to patients with myocardial ischaemia who are not hypoxaemic [7]. Specifically, high concentration oxygen treatment increases coronary vascular resistance and reduces coronary blood flow [3,[8][9][10][11], increases systemic vascular resistance and blood pressure, and reduces cardiac output [12][13][14][15][16][17][18][19]. The magnitude of these physiological responses may be substantial, as illustrated by a recent systematic review and metaanalysis which reported that high concentration oxygen reduces coronary blood flow by 8 to 29% and increases coronary vascular resistance by 22% to 41% [11].…”