The Effects of Overfeeding on the Neuronal Response to Visual Food Cues in Thin and Reduced-Obese Individuals

Cornier, Marc‐Andre; Salzberg, Andrea K.; Endly, Dawnielle C.; Bessesen, Daniel H.; Rojas, Donald C.; Tregellas, Jason R.

doi:10.1371/journal.pone.0006310

Cited by 138 publications

(152 citation statements)

References 49 publications

(68 reference statements)

Supporting

Mentioning

144

Contrasting

Unclassified

Order By: Relevance

“…Several studies have evaluated neuronal responses to visual food cues at rest, showing changes in brain regions essential to the regulation of energy intake [48][49][50][51][52][53][54][55][56]. Killgore et al [51] observed significant activity in numerous food reward, inhibitory control, and visual brain regions (e.g., insula, amygdala, medial frontal gyrus, precuneus, etc.)…”

Section: Exercise and Neuronal Responsesmentioning

confidence: 99%

Exercise and Weight Loss: What Is the Evidence of Sex Differences?

Hagobian

Evero

2012

Curr Obes Rep

View full text Add to dashboard Cite

Regular physical activity, in the form of structured daily exercise, plays a large role in obesity management. Previous studies suggest that when sedentary men and women start an exercise training program, men lose more body weight than women. This has led researchers to reason that women are better at defending weight than men in response to exercise. In this article, we review exercise studies examining weight loss in men and women, and highlight hormonal, neuronal, and ad libitum energy intake responses to physical activity that is consistent with or in disagreement with sex differences in weight loss. The developing story may impact our view on the use of physical activity to influence body weight and whether a true sex difference is evident.

show abstract

Section: Exercise and Neuronal Responsesmentioning

confidence: 99%

Exercise and Weight Loss: What Is the Evidence of Sex Differences?

Hagobian

Evero

2012

Curr Obes Rep

View full text Add to dashboard Cite

show abstract

“…Although the majority of studies investigating food reward-processing differences between obese versus healthy-weight participants have been conducted during hunger or moderate deprivation, 17,[20][21][22]27 the excess of energy intake in obesity is at least partly because of eating in the absence of hunger, also called nonhomeostatic eating. 28,29 Therefore, the current study seeks to investigate food reward-processing differences between overweight participants and healthy-weight ones while they are satiated.…”

Section: Introductionmentioning

confidence: 99%

Reward activity in satiated overweight women is decreased during unbiased viewing but increased when imagining taste: an event-related fMRI study

et al. 2011

View full text Add to dashboard Cite

Objective: The aim of this functional magnetic resonance imaging (fMRI) study was to investigate reward-related brain activity in satiated overweight and healthy-weight participants in response to high-calorie palatable food pictures, when viewing the pictures without prior instructions (called unbiased viewing) versus imagining the taste of the shown pictures (called taste imagination). We predicted that neural activation in brain reward regions would be greater in overweight participants than in healthy-weight ones and that this difference between groups would be strongest during unbiased viewing. Method: Neural activation was measured using fMRI in 14 overweight (mean body mass index (BMI): 29.8 kg m À2 ) and 15 healthy-weight (mean BMI: 21.1 kg m À2 ) participants who were satiated, in response to palatable and unpalatable highcalorie and low-calorie food pictures, presented in an event-related design during two conditions: unbiased viewing (no prior instructions) versus taste imagination. Results: A group Â condition interaction was found in 14 brain regions involved in food reward processing during the presentation of high-calorie palatable food stimuli. During the taste imagination condition, neural activation in these regions was greater in the overweight participants than in the healthy-weight ones. Contrary to our expectations, the opposite pattern was observed during unbiased viewing: activation in reward regions in the overweight participants was reduced compared with the healthy-weight ones. In all brain reward regions except for the left amygdala, the group Â condition interaction was specific to high-calorie palatable food stimuli. Conclusion: Greater reward activity in the overweight participants compared with the control group when imagining taste may represent an increased reward response induced by high-calorie palatable food. During unbiased viewing, reduced reward activation in the overweight participants compared with those with a healthy weight may reflect avoidance of high-calorie palatable food stimuli. Taken together, this pattern of activation may reflect ambivalence in the overweight group between desire for (in the taste imagination condition) and avoidance of (in the unbiased viewing condition) high-calorie palatable food stimuli.

show abstract

“…Recent fMRI studies suggest obese and normal-weight individuals differ substantially in their neural activation in response to visual food cues (17,83,96,105 Moreover, no information was reported on the subject"s dietary restraint or previous dieting habits, so the findings could be attributed to this group of obese men attempting to suppress the rewarding signals of food (e.g. similar to that of successful dieters).…”

Section: Neuronal Response In Obese Individualsmentioning

confidence: 99%

“…Given no previous study has examined the brain response of normal-weight or over-weight individuals to visual food cues after a single bout of exercise, a priori ROI that have previously been reported in the regulation of food intake were used (e.g. dorsolateral PFC, OFC, insula and the hypothalamus) (16,17,50,83).…”

Section: Experimental Designmentioning

confidence: 99%

“…In our study, subjects were healthy, normal-weight and habitually active. In contrast, others used sedentary, overweight or obese individuals (17,71,83) or did not report physical activity levels (50). Previous studies have found that habitually active individuals have suppressed appetite hormones and no increase in food intake after exercise (54, 116).…”

Section: Conditionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Exercise on Brain Responses to Visual Food Cues: An fMRI Study

Evero¹

View full text Add to dashboard Cite

Impact of Exercise on Brain Responses to Visual Food Cues: An fMRI Study Nero Erezi EveroOn the basis of a strong body of data, the Institute of Medicine currently recommends at least 60 minutes of exercise per day to prevent body weight gain overtime. Previous studies have shown that there is no compensatory increase in food intake with this dose of exercise. Ultimately, the brain decides whether to alter food intake. Surprisingly, no published studies have assessed the impact of exercise on brain activation. Using functional magnetic resonance imaging (fMRI) and an appetite questionnaire, we investigated the effects of a single bout of aerobic exercise on brain responses to visual food cues and subjective appetite responses. After an overnight fast, 30 (17M, 13W), healthy, habitually active subjects (22.0±3.8 years, 23.6±2.4 kg/m 2 , 44.3±8.3 mL•kg -1 •min -1 ) either rested or exercised for 60 minutes, in a counterbalanced crossover design. Immediately after each condition, blood oxygen dependent levels were determined in response to visual food cues of different energy value during an fMRI scan. Exercise showed significantly greater activation (P < .005, uncorrected) in regions implicated in food inhibition (superior frontal gyrus, medial surface), and visual attention (precuneus, superior temporal gyrus, middle temporal gyrus and fusiform gyrus) regions.However, exercise did show a greater activation in a food reward region (medial orbitofrontal cortex). The rest condition only showed greater activation in a visual center (fusiform gyrus) and the midbrain. In addition, relative to no-exercise, subjective appetite responses were suppressed following the exercise bout. Taken altogether, these v data suggest exercise may impact the brain in a direction expected to suppress food intake and increase food attention, which is in line with previous behavioral, biological and fMRI data. These findings may explain, at least partially, why aerobic exercise does not lead to a compensatory increase in food intake.

show abstract

The Effects of Overfeeding on the Neuronal Response to Visual Food Cues in Thin and Reduced-Obese Individuals

Cited by 138 publications

References 49 publications

Exercise and Weight Loss: What Is the Evidence of Sex Differences?

Exercise and Weight Loss: What Is the Evidence of Sex Differences?

Reward activity in satiated overweight women is decreased during unbiased viewing but increased when imagining taste: an event-related fMRI study

Impact of Exercise on Brain Responses to Visual Food Cues: An fMRI Study

Contact Info

Product

Resources

About