The Effects of Oral Vitamin E on Induction and Consequence of Experimental Diabetes Mellitus in Rats

Abstract

Streptozotocin destroys the beta-cells of pancreas by generation of reactive oxygen species and vitamin E has documented antioxidant properties. To evaluate the preventive effect of vitamin E on induction of diabetes by streptozotocin and effect of oral vitamin E consumption on carbohydrate and lipid metabolism, forty male Wistar rats divided randomly to control, E1, E2 and E3 groups. The diet of E1, E2 and E3 groups were supplemented with 1, 2 and 4 g kg(-1) of vitamin E, respectively. Four days later all rats were made diabetic by IP injection of 45 mg kg-' streptozotocin and blood glucose was measured 72 h later to determine the severity of blood glucose elevation. Glycosylated hemoglobin, triglyceride, total cholesterol and HDL-c were measured and LDL-c and VIDL-c calculated in plasma of 6 diabetic rats with glucose more than 200 mg dL(-1) in each groups 21 days after streptozotocin injection. Vitamin E had no effect on diabetes induction by streptozotocin, but elevation of glycosylated Hb and reduction of LDL-c in group E3 were significant. Vitamin E also increased HDL-c although it was not statistically significant. We suggest that oral vitamin E consumption may have some beneficial effect on the correction of lipid metabolism disorders of diabetes, although it may worsen carbohydrate metabolism in mild diabetes.

Effects of oxidised oil and vitamin E on performance and some blood traits of heat-stressed male broilers

“…These results seem to agree with many previous reports in which higher TBARS levels were obtained in birds fed oxidised oil (Sheehy et al, 1993;1994;Engberg et al, 1996). Similar findings have also been reported in rats (Eder & Kirchgessner, 1999;Juskiewicz et al, 2000;Eder et al, 2003;Tabatabaei, 2008). However, Eder (1999a) suggested that the susceptibility of plasma lipids to lipid peroxidation was not significantly affected by feeding oxidised oil to miniature pigs.…”

Biological Effect of Sucralose in Diabetic Rats

“…In the current study, diabetic rats showed a significant increase of glucose associated to a significant decrease of insulin, level, compared to their respective values in the control group. This could be explained by the fact that STZ induces degeneration in Langerhans islet beta cells [33][34][35]. The administration of sucralose to diabetic rats has no effect on insulin while reduces glucose level, compared to diabetic rats receiving distilled water.…”

Pengaruh Pemberian Campuran Bee Pollen, Serbuk Rimpang Kencur, Serbuk Rimpang Kunyit, Biji Pinang Dan Daun Sirih Terhadap Volume Urin Pada Tikus Wistar Pasca Paparan Streptozotocin (Stz)

“…Penelitian yang dilakukan oleh Sreemantula et al, (2005) menyatakan bahwa suplementasi antioksidan berguna untuk mengontrol kadar glukosa darah dan mencegah terjadinya komplikasi DM. Konsumsi vitamin E secara oral memberikan efek baik pada gangguan metabolisme lipid pada DM (Tabatabaei et al, 2008).…”