The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study

Safety assessment of a highly bioavailable curcumin-galactomannoside complex (CurQfen) in healthy volunteers, with a special reference to the recent hepatotoxic reports of curcumin supplements: A 90-days prospective study

“…Once swell in the gastrointestinal tract, CGM has been shown to act as a self-emulsifying hydrogel with high mucoadhesive character, capable of delivering amphiphilic colloidal curcumin particles that can be absorbed quickly. CGM has already demonstrated its superior efficacy in a relatively low dosage [ [32] , [33] , [34] ], with improved brain bioavailability as revealed by its influence on brain waves [ 35 ], radioprotective [ 36 ] and neuroprotective effects [ 37 , 38 ]. CGM was reported to exhibit 45-fold enhancement in the bioavailability of free curcuminoids and 270-fold enhancement in the bioavailability of total curcuminoids (sum of conjugated and unconjugated), when compared to an equivalent dose of unformulated standard curcuminoids with 95 % purity [ 31 ].…”

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

“…Indeed, third-generation formulations have been developed recently and these formulations include curcumin galactomannan formulation or CurQfen (noncovalent complex between curcumin and fenugreek galactomannans), curcuRouge (Starch and curcumin formulation), Curcuwin Ultra (cellulosic derivatives and curcumin formulation), and Longvida (soy lecithin and curcumin formulation) (Figure ). ,, CurQfen was shown to be safe and well-tolerated and had no adverse side effects have been reported in clinical trials. ,− This formulation also improved α- and β-waves of EEG, memory improvement, and reduced choice-based-visual reaction time in healthy subjects . It also improved walking performance, VAS score, and WOMAC score, and inhibited the rise in hs-CRP, IL-1β, and IL-6 levels in osteoarthritis patients. , In addition, its antiobesity and anti-CVD properties were attributed to its increased levels of HDL and reduced levels of homocysteine within 12 weeks of treatment .…”

“…44,298−301 This formulation also improved αand β-waves of EEG, memory improvement, and reduced choice-based-visual reaction time in healthy subjects. 302 It also improved walking performance, VAS score, and WOMAC score, and inhibited the rise in hs-CRP, IL-1β, and IL-6 levels in osteoarthritis patients. 298,301 In addition, its antiobesity and anti-CVD properties were attributed to its increased levels of HDL and reduced levels of homocysteine within 12 weeks of treatment.…”

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

“…In another randomized controlled trial, curcumin (190 mg/day) and fenugreek fiber (300 mg/day) for 28 days enhanced the neuromuscular fatigue threshold after exercise in untrained college-aged subjects ( n = 47) . A randomized, double-blind, placebo-controlled clinical trial demonstrated that curcumin (1000 mg/day) reduced audio-reaction time, choice-based visual reaction time, and improved memory in 18 volunteers aged 30–65 years . This study also showed that curcumin-galactomannan (1000 mg/day) supplementation resulted in a remarkable increase in α- and β-waves of the brain and decreased the α/β ratio, audio-reaction time, choice-based visual reaction time, and improved memory in these volunteers .…”

“…A randomized, double-blind, placebo-controlled clinical trial demonstrated that curcumin (1000 mg/day) reduced audio-reaction time, choice-based visual reaction time, and improved memory in 18 volunteers aged 30–65 years . This study also showed that curcumin-galactomannan (1000 mg/day) supplementation resulted in a remarkable increase in α- and β-waves of the brain and decreased the α/β ratio, audio-reaction time, choice-based visual reaction time, and improved memory in these volunteers . In a study of the effect of environmental heat and antioxidant (curcumin) ingestion in firefighters ( n = 10 male adults), heat plus curcumin supplementation (1500 mg/dose) prior to exercise increased the levels of glutathione (GSH) in these subjects.…”