The Effects of N-Acetylcysteine on Antioxidant Enzyme Activities in Experimental Testicular Torsion

Çay, Ali; Alver, Ahmet; Küçük, Murat; Işik, Osman; Eminağaoğlu, M. Selçuk; Karahan, Süleyman Caner; Değer, Orhan

doi:10.1016/j.jss.2005.11.572

Cited by 81 publications

(37 citation statements)

References 25 publications

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“…Many studies concerning I/R injury have used NAC on the basis of its antioxidant characteristics. Ç ay et al (19) investigated the effects of NAC in a rat model of testicular T/D. They demonstrated that systemic administration of NAC inhibited lipid peroxidation during reperfusion of testicular tissue, reducing MDA levels, and preventing histopathological damage.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

Turkmen

Menteşe

Karagüzel

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

Turkmen

Menteşe

Karagüzel

et al. 2012

Fertility and Sterility

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“…L-Carnitine has been shown to be valuable also in the recovery of gastric mucosa, liver, neuron and kidney tissues, which were subjected to ischemia and reperfusion in different studies [11][12][13][14]. NAC has also been studied on ischemia-reperfusion injuries of tissues like testis, myocard, and kidney and was shown to be effective in the treatment of those injuries [15][16][17][18][19]. Although tissue damage diminishes by long period of reperfusion, our results show that, treatment with both Lcarnitine and NAC accelerates tissue recovery.…”

Section: Discussionmentioning

confidence: 99%

“…N-Acetyl cysteine (NAC) was introduced as a mucolytic drug in the 1960s [16]. Later, as a precursor of glutathione and as a well-known thiol containing antioxidant, NAC was discovered as a scavenger of FORs [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Later, as a precursor of glutathione and as a well-known thiol containing antioxidant, NAC was discovered as a scavenger of FORs [17,18]. NAC easily penetrates cell membranes and unlike cysteine, the rate-limiting amino acid in glutathione synthesis, has a very low toxicity [16]. Thus, from a clinical point of view, NAC is an attractive drug because of its scarce side effects and because there is considerable experience of its use in critically ill patients [19].…”

Section: Introductionmentioning

confidence: 99%

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Tissue damage in rat ovaries subjected to torsion and detorsion: effects of l-carnitine and N-acetyl cysteine

et al. 2008

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We aimed to evaluate histopathological changes, to detect HIF-1alpha staining intensities and to determine MDA levels in rat ovaries, which were subjected to torsion and detorsion and treated with L -carnitine or N-acetyl cysteine (NAC). Forty-eight prepubertal female Sprague-Dawley rats were divided into five groups (n = 8): 1, control; 2, ischemia; 3, reperfusion; 4, L -carnitine; and 5, NAC groups. In groups 3, 4 and 5, an ischemic period of 3 h was followed by reperfusion for 24 h. In groups 4 and 5, ischemia was performed and either L -carnitine or NAC was infused intraperitoneally 30 min before reperfusion. Ovarian tissues were examined histopathologically; tissue MDA levels and serum IL-6 levels were determined biochemically. HIF-1alpha was applied to all ovaries immunohistochemically. Total tissue damage scores, tissue MDA levels and HIF-1alpha scores, were significantly higher in group 2 (all P < 0.001) than group 4, and group 3 than group 4 (P < 0.001, P = 0.05 and P < 0.001, respectively). They were also significantly higher in group 2 (all P < 0.001) than group 5. When group 3 is compared to group 5, total tissue damage scores and tissue MDA levels were significantly higher in the former (P < 0.01 and P < 0.001, respectively). Serum IL-6 levels were significantly higher in group 2 when compared to groups 1, 4 and 5 (all P < 0.01). The degree of tissue damage of the torsioned ovaries decreased after a reperfusion period of 24 h in the torsioned ovaries. However, ovaries of both L -carnitine and NAC groups showed better recovery than the reperfusion group.

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“…2 Experimental studies have shown that spermatogonia and spermatocytes are the most sensitive cells for testicular ischemia. 3 Free-oxygen radicals are linked with ischemia reperfusion (I/R) injury. 1 These free-oxygen radicals exert their deleterious effects by destruction of the structural elements of the cell.…”

Section: Introductionmentioning

confidence: 99%

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

Kemahlı

Yildiz

Fırat

et al. 2016

CUAJ

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Introduction: The aim of this experimental study was to investigate the histopathological and biochemical effects of pyrrolidine dithiocarbamate, an antioxidant and inhibitor of NF-kβ, on ischemiareperfusion injury in rats. Methods: A total of 21 male Wistar-Albino rats were randomly distributed into three groups as sham group (Group 1), ischemia-reperfusion (I/R) group (Group 2) and I/R with pyrrolidine dithiocarbamate (PDTC) group (Group 3). Left testicles of rats in Groups 2 and 3 underwent testicular torsion of 720° for four hours and 100 mg/ kg of PDTC was administered intraperitoneally prior to detorsion in Group 3. An hour after detorsion process, left orchiectomies were performed and 5 ml of intracardiac blood samples were drawn from rats in all three groups. Histopathological examination of testis tissues performed and measurement of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in blood samples were taken. Results: Elevated levels of MDA and decreased SOD activity, together with decreased Johnson tubular biopsy scores consistent with I/R injury were observed in Group 2 (p<0.05). Group 1 and Group 3 were similar in terms of MDA levels, SOD activity, and Johnson scores (p>0.05). Conclusions: Our results indicated that PDTC may have beneficial effects for alleviation of I/R injury in testicular tissue in rats. Understanding the underlying mechanisms and exploration of its diagnostic and therapeutic potential requires further randomized, controlled trials on a larger scale.

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The Effects of N-Acetylcysteine on Antioxidant Enzyme Activities in Experimental Testicular Torsion

Cited by 81 publications

References 25 publications

A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

Tissue damage in rat ovaries subjected to torsion and detorsion: effects of l-carnitine and N-acetyl cysteine

An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

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