The effects of morphine and morphine conditioned context on 50kHz ultrasonic vocalisation in rats

Hamed, Adam; Taracha, Ewa; Szyndler, Janusz; Krząścik, Paweł; Lehner, Małgorzata; Maciejak, Piotr; Skórzewska, Anna; Płaźnik, Adam

doi:10.1016/j.bbr.2012.01.053

Cited by 38 publications

(30 citation statements)

References 24 publications

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“…High doses of naloxone reduced 50 kHz USVs and increased 22 kHz USVs (Burgdorf et al 2001b). Other studies reported a role for opioids in the number or characteristics of 50 kHz USVs (Hamed et al 2012; Simola et al 2012; Vivian and Miczek, 1993). Dopamine administration in the nucleus accumbens (Burgdorf et al 2001a) and indirect dopamine agonism by psychostimulants (Burgdorf et al 2001a; Brudzynski et al 2012; Thompson et al 2006; Williams and Undieh 2010; Wintink and Brudzynski 2001) have been shown to increase 50 kHz USVs.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats

et al. 2013

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Rationale-Fifty kilohertz ultrasonic vocalizations (USVs) have been sometimes shown to reflect positive affective-like states in rats. Rewarding events, such as access to palatable food or drugs of abuse, increase the number of anticipatory 50 kHz USVs. However, little is known about the predictability of USVs, subtypes of USVs involved, and underlying neurobiological mechanisms.Objectives-We examined whether cue-induced anticipatory 50 kHz USVs predict palatable food intake and tested the effects of dopamine D 1 and μ-opioid receptor antagonism on anticipatory USVs.Materials-Food-restricted rats received repeated sessions of a 2 min cue light immediately followed by 5 min access to palatable food. Ultrasonic vocalizations were recorded during cue presentation. After 24 pairing sessions, the rats were pretreated with the D 1 receptor antagonist SCH 23390 (5, 10, and 20 μg/kg) and μ-opioid receptor antagonist naltrexone (0.03, 0.06, 0.13, 0.25, 0.5, and 1 mg/kg) in a Latin-square design, and USVs were recorded during cue presentation.Results-Rats emitted 50 kHz USVs during cue presentation, and the number of USVs increased across sessions with robust and stable interindividual differences. Escalation in USVs was subtype-dependent, with non-trill calls significantly increasing over time. Palatable food intake was positively correlated with anticipatory 50 kHz USVs. Moreover, anticipatory USVs were dose-dependently prevented by antagonism of D 1 and μ-opioid receptors.Conclusions-These findings demonstrate that anticipatory 50 kHz USVs represent a stable phenotype of increased motivation for food, and dopamine and opioid systems appear to mediate anticipatory 50 kHz USVs.

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Section: Discussionmentioning

confidence: 99%

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats

et al. 2013

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“…For example, activation of drug-paired CSs enhance operant responses in the absence of drugs (Di Ciano and Everitt 2003), and can even maintain responding when delivered contingently (Rescorla and Solomon 1975;Tunstall and Kearns 2017). Moreover, in place conditioning, when a drug reinforcer is administered in a specific context, the contextual CS gains the ability to attract the animal when in a drug-free state (for review, see Tzschentke 1998), and can induce ultrasonic vocalizations similarly to acute injections of the drug (Ahrens et al 2009;Ma et al 2010;Hamed et al 2012). Drug-paired CSs also acquire the ability to elicit other behavioral responses (e.g., conditioned locomotion) and modify various physiological functions (e.g., heart and respiratory rates) (Bloch et al 1973;Fitzgerald et al 1984;Blanco et al 2012).…”

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confidence: 99%

Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats

et al. 2019

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To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance memory consolidation, the effects of post-training exposure to cocaine and nicotine were compared to the effects of post-training exposure to contextual stimuli that were paired with the effects of these drugs. Using the object recognition (OR) task, it was first demonstrated that both 10 and 20 mg/kg cocaine, and 0.2 and 0.4 mg/kg nicotine, enhanced recognition memory when administered immediately after, but not 6 h after the sample phase. To establish the drug CSs, rats were confined for 2 h in a chamber (the CS+) after injections of 20 mg/kg cocaine, or 0.4 mg/kg nicotine, and in another chamber (the CS−) after injections of vehicle. This was repeated over 10 d (5 drug/CS+ and 5 vehicle/CS− pairings in total). At the end of this conditioning period, when tested in a drug-free state, rats displayed conditioned hyperactivity in the CS+ relative to the CS−. More important, immediate, but not delayed, post-sample exposure to the cocaine CS+, or nicotine CS+, enhanced OR memory. Therefore, this study reports for the first time that contextual stimuli paired with cocaine and nicotine, like the drugs themselves, have the ability to enhance memory consolidation.

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“…It has previously been shown that some pharmacological treatments can alter USVs in rodents. For example, morphine has been demonstrated to reduce 50 kHz USVs52, whereas the GABA A receptor antagonist, pentylenetetrazol, can cause an increase in USVs in rats53. Therefore, FTY720 may increase 50 kHz USVs in mice through pharmacological actions on S1PRs in the CNS and/or in other systems where S1PRs are expressed.…”

Section: Discussionmentioning

confidence: 99%

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations

Sheridan

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2014

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Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The protective effects of FTY720 in EAE are primarily scored manually by examining weight loss and limb paralysis that begins around 10–12 days after immunisation. To our knowledge, pre-clinical effects of FTY720 on animal behaviour early in EAE have not been explored. Here, we developed an automated behaviour monitoring system to examine the early effects of FTY720 on subtle pre-symptomatic behaviour of mice induced with EAE. Our automated home-cage monitoring system (AHC-MS) enabled non-contact detection of movement and ultrasonic vocalisations (USVs) of mice induced with EAE, thus allowing detection of subtle changes in mouse behaviour before paralysis occurs. Mice receiving FTY720 emit longer USVs and display higher levels of motor activity than vehicle-treated EAE mice before clinical symptoms become apparent. Importantly, this study promotes the 3Rs ethics (replacement, reduction and refinement) in the EAE animal model and may also improve pre-screening of potentially novel MS therapies. In addition, this is the first report showing the early effects of FTY720 in EAE which underscores its protective effects.

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The effects of morphine and morphine conditioned context on 50kHz ultrasonic vocalisation in rats

Cited by 38 publications

References 24 publications

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats

Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations

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