The Effects of Mometasone Furoate and Desloratadine in Obstructive Sleep Apnea Syndrome Patients with Allergic Rhinitis

Abstract

Nasal obstruction due to nasal congestion causes increases in airway resistance and can lead to development of OSAS. We concluded that treating AR with Ns has both positive effects on OSAS and daily activity. However, adding Ah to this treatment did not show improved effects compared with placebo treatment.

Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature

“…Several nasal decongestants have been trialed for OSA severity. The effect on AHI of mometasone alone and in combination with the antihistaminic desloratadine was measured in patients with allergic rhinitis by Acar et al [42] in a four-arm (mometasone, desloratadine, mometasone + desloratadine and placebo) trial with 80 patients. While desloratadine alone or in combination with mometasone did not show significant improvement of OSA severity, mometasone alone did, with a reduction in AHI by 17% compared to placebo.…”

Rhinitis in the Elderly

“…[46] Two recent studies evaluated the effects of allergic rhinitis treatment for OSA, and both found significant improvements in OSA symptomatology. [47, 48] Underlying mechanisms of the improvement were thought to be related to improvements in nasal inflammation with a resultant decreased nasal obstruction. Although the mean age of the participants in these studies was approximately 49 years, the results may also be applicable to older adults – though again, further studies are needed.…”

Topical nasal treatment efficacy on adult obstructive sleep apnea severity: a systematic review and meta‐analysis

“…The primary outcome of interest, reported in all 8 studies in our systematic review, was AHI, providing posttreatment data for a total of 228 patients. [22][23][24][25][26][31][32][33] Three of these studies evaluated nasal steroids 24,31,32 and, of these, 2 were placebo-controlled. 24,32 Qualitatively, all nasal steroid studies showed statistically significant improvement in AHI compared with pretreatment or placebo.…”

“…Four studies showed a 1-to 4-point reduction in ESS scores with TNTs, 23,31-33 2 of which demonstrated a statistically significant improvement. 31,32 According to Patel et al, the minimum clinically important difference (MCID) for ESS scores in adult OSA patients who were treated with CPAP was approximately −2.65. Of the studies we reviewed, only 1 demonstrated a clinically significant improvement in ESS greater than the MCID.…”