Rhinitis in the Elderly

Baptist, Alan P.; Nyenhuis, Sharmilee M.

doi:10.1016/j.iac.2015.12.010

Cited by 48 publications

(44 citation statements)

References 79 publications

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“… 19 Antihistamines are effective in reducing rhinitis symptoms in the elderly, but cause adverse effects, such as urinary retention, dry mouth, constipation, arrhythmia and postural hypertension. 20 21 In the present study, total use of antihistamines tended to be lower in the treatment group than in the control group; therefore, SLIT may be beneficial for elderly rhinitis patients to reduce total medication use.…”

Section: Discussionsupporting

confidence: 42%

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

Kim

Lee

et al. 2018

Allergy Asthma Immunol Res

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PurposeThis study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR.MethodsA total of 45 patients aged ≥ 60 years with HDM-induced AR who had ≥ 3 A/H ratio on skin prick test and/or ≥ 0.35 IU/L to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15). Rhinoconjunctivitis total symptom score (RTSS), rhinoscopy score, Korean rhinoconjunctivitis quality of life questionnaire, rhinitis control assessment test, asthma control test scores, and adverse reactions, were assessed at the first visit (V1) and after 1 year of treatment (V5); for immunological evaluation, serum levels of HDM-specific immunoglobulin A/IgE/IgG1/IgG4 antibodies and basophil response to HDMs were compared between V1 and V5 in both groups.ResultsThere were no significant differences in demographics, RTSS, skin reactivity to HDMs, or serum total/specific IgE levels to HDMs (P < 0.05, respectively) between the 2 groups. Nasal symptom score and RTSS decreased significantly at year 1 in the 2 groups (P < 0.05). There were no significant differences in percent decrease in nasal symptom score and RTSS at year 1 between the 2 groups (P < 0.05); however, rhinoscopic nasal symptom score decreased significantly in the SLIT-treated group (P < 0.05). Immunological studies showed that serum specific IgA levels (not specific IgE/IgG) and CD203c expression on basophils decreased significantly at V5 in the SLIT-treated group (P = 0.011 and P = 0.001, respectively), not in the control group. The control group required more medications compared to the treatment group, but there were no differences in adverse reactions.ConclusionsIt is suggested that HDM-SLIT for 1 year could induce symptom improvement and may induce immunomodulation in elderly rhinitis patients.

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Section: Discussionsupporting

confidence: 42%

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

Kim

Lee

et al. 2018

Allergy Asthma Immunol Res

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“…In a retrospective study, Wang et al demonstrated that increasing age was associated with a decreased positivity in sIg 27 , which might be the cause of our result. Yet, other researches showed that both AR and NAR are more common among the elderly than the younger population 28,29 .…”

Section: Discussionmentioning

confidence: 92%

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Huang

Zhang

2020

Preprint

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Background It is difficult to discriminate allergic rhinitis (AR) and nonallergic rhinitis (NAR) in clinical practice due to the similar clinical manifestations. The study was to assess both the demographical and clinical features of AR and NAR in the real-world data of outpatients in China Methods It was a cross-sectional real-world study. AR and NAR were defined based on both subjective symptoms and objective specific serum IgE test. General demographic characteristics as well as clinical information was documented. Patients were further classified according the seasons of initial visiting hospital (during pollen seasons or not). A scoring system presented as nomograms for presence of AR was performed. Results In pollen season group, age distribution, the duration of rhinitis, comorbidity of asthma, food allergies and score of coughing were found significantly associated with AR. Besides, in non pollen season group, we found that ethnicity, age distributions, duration of rhinitis, comorbidity of asthma, food allergies, family history of allergy, together with scores of gritty eyes were associated factors of AR. Based on multivariate logistic model, we built two nomograms which included previously identified significant risk factors that could be easily acquired during clinical practice with predictive variables to assess their roles in predicting the risk of AR among outpatients with rhinitis. Conclusions The characteristics of patients with different phenotypes of chronic rhinitis are distinctive in different seasons and the developed monogram in this study might be beneficial for clinical practice.

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“…Although most reports published on the topic of aging of the nose are about nasal epithelial change, olfaction or taste, it may be deduced from previous reports that mucociliary clearance may change with aging. [7,26] The number of goblet cells decreases, resilient structures atrophy, and the basement membrane gets thicker with aging. [27] However, there is no significant agerelated change in gross or electron microscopic examination of the histopathology of the mucosa of either the septum or the turbinates.…”

Section: Discussionmentioning

confidence: 99%

“…[5] The prevalence in geriatric patients is suggested to be around 12%. [7] Epidemiologic data on rhinitis in the elderly are often neglected; however, the older population also has complaints of AR and nasal obstruction which decrease their quality of life. [8] From this point of view, studies are needed to raise the awareness of this disease in the elderly population since modern life has increased the tendency toward AR in older patients as well as in the younger age groups.…”

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confidence: 99%

Subjective feeling of nasal obstruction and its response to nasal steroids in the elderly

Önder¹

2018

Tr-ENT

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Objectives: This study aims to compare the effectiveness of topical nasal steroids for nasal obstruction symptoms between advanced age patients and young-middle age patients based on acoustic rhinometry values and correlations with mucociliary clearance. Patients and Methods: Our study population consisted of 27 advanced aged patients (15 males, 12 females; mean age 67 years; range, 65 to 76) (group 1) and 36 young-middle aged patients (20 males, 16 females; mean age 36.1 years; range, 15 to 49 years) (group 2). Patients with a history of allergic rhinitis (AR) with positive skin prick tests were referred from the Department of Respiratory Medicine. All patients were evaluated with objective and subjective methods before and after using topical nasal steroids for six weeks. We used rhinometric evaluation and saccharin test as objective methods and assessed patients with nasal obstruction symptom evaluation (NOSE) and visual analog scale (VAS) as subjective methods. Results: Baseline subjective scores of group 1 were significantly lower than group 2 (p<0.05). Percent change of VAS and NOSE scores were markedly higher in group 2 compared to group 1 (p<0.05). There was no significant difference between groups in terms of the change in saccharin time following nasal steroid treatment (p>0.05). Baseline total minimum cross-sectional area (MCA3) and total volume of nasal cavity (VOL3) values of group 1 were significantly higher than group 2 (p<0.05). The change of MCA3 and VOL3 values did not differ between the groups before and after treatment with nasal steroids (p>0.05). Conclusion: In this study, we have shown that the elderly have reduced awareness of their nasal symptoms of AR. We have demonstrated that topical treatment with nasal steroids was more effective in the young-middle age group subjectively.

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Rhinitis in the Elderly

Cited by 48 publications

References 79 publications

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

Developing Nomograms for Identifying Allergic Rhinitis Among Chronic Rhinitis: A Real-world Study

Subjective feeling of nasal obstruction and its response to nasal steroids in the elderly

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