The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial

Berger, Richard S.; Fu, Jen-Tso; Smiles, Kenneth A.; Turner, C. B.; Schnell, Beverly; Werchowski, K. M.; Lammers, Karen M.

doi:10.1046/j.1365-2133.2003.05435.x

Cited by 69 publications

(37 citation statements)

References 16 publications

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“…[9] Zinc has been shown to have an antiandrogenic potential and it specifically inhibits 5α-reductase type 1 and 2 activity, thus promoting hair growth. [242526] It also has considerable effect on hair growth in androgenic alopecia in a randomized, clinical study. [25] It is difficult to explain the likelihood of low serum zinc levels in FAGA in the studied sample in comparison to healthy control, however, low dietary zinc intake or imbalance diet in genetically susceptible individuals are suggested.…”

Section: Discussionmentioning

confidence: 99%

Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

Dhaher

Yacoub

Jacob³

2018

Indian J Dermatol

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Background:Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role.Aim of the Study:This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls.Patients and Methods:A case–control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. The participants were divided into two groups: The first group consisted of 27 women with FAGA and the second was age-matched 28 healthy women control group. The serum and hair zinc and iron assays were done for all participants.Results:Both hair and serum zinc levels in FAGA group were significantly lower than that in the control (103.4±25.5 ppm vs. 143.5±33.1 ppm for hair and 65.6±14.2 μg/dl vs. 128.4±41.4 μg/dl for serum). Hair iron level in FAGA was significantly lower than in control (17.9±3.8 ppm vs. 26.9±7.4 ppm, P>0.05). Serum iron level in FAGA group was lower than in the control, but it was not significant statistically (88.9±22.3 μg/dl vs. 100.9±18.9 μg/dl). Except for the hair iron, there was no significant correlation between zinc and iron concentrations in hair and serum with severity of alopecia.Conclusions:Zinc and iron levels in serum and hair were lower in FAGA compared to that of normal individuals indicating that trace elements might play an important role in the etiopathogenesis of FAGA.

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Section: Discussionmentioning

confidence: 99%

Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

Dhaher

Yacoub

Jacob³

2018

Indian J Dermatol

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“…For example, comparison of the hairs from D/SD and normal populations demonstrated D/SD-derived hair to be more narrow, with a more brittle surface and less shine (18,19). D/SD can also contribute to increased rates of hair loss (4,20), which may be directly due to the presence of Malassezia (20,21); anti-dandruff shampoos with anti-fungal actives appear to reduce hair loss even in androgenic alopecia populations (22,23), ñirther supporting a potential involvement of Malassezia.…”

Section: Signs and Symptoms Of Dandruff And Seborrheic Dermatitismentioning

confidence: 99%

“…Taken together, these molecular biomarker observations provide a further insight into the picture of the pathophysiology of the D/SD condition and offer more detailed evidence of resolution with commercially available treatments. While there is a consistency between resolution of signs and symptoms of D/SD and the normalization of the biomarkers [22,32], we sought to assess the statistical significance of the correlations. The commonly assessed variable of flake reduction as quantified by the adherent scalp flake score (ASFS) (44) was used as the accepted clinical endpoint.…”

Section: Biomolecular Changesmentioning

confidence: 99%

A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis – Towards a More Precise Definition of Scalp Health

Schwartz¹,

Messenger²,

Tosti³

et al. 2013

Acta Derm Venerol

113

108

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Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper-proliferative epidermal responses. The objective of this report is to review published literature from in vivo studies of D/SD populations to provide a more complete description of overall scalp health. New biomolecular capabilities establish a depth of pathophysiological understanding not previously achievable with traditional means of investigation. Biomarkers representing inflammation, hyper-proliferation and barrier function are all perturbed by the D/SD condition and robustly respond to therapeutic resolution. These biomarkers can be sampled noninvasively, enabling their use in routine clinical evaluations as either surrogate endpoints or complementary ones to classical signs/symptoms to broaden the etiological learning.

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“…However, the 1% pyrithione zinc group had only a modest improvement in hair growth, with hair counts less than half of the MXD group. No increase in hair count was noted between the combination therapy versus MXD alone [102].…”

Section: Zincmentioning

confidence: 80%

Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

Hosking

Juhász

Mesinkovska

2018

Skin Appendage Disord

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The treatment of alopecia is limited by a lack of therapies that induce and sustain disease remission. Given the negative psychosocial impact of hair loss, patients that do not see significant hair restoration with conventional therapies often turn to complementary and alternative medicine (CAM). Although there are a variety of CAM treatment options on the market for alopecia, only a few are backed by multiple randomized controlled trials. Further, these modalities are not regulated by the Food and Drug Administration and there is a lack of standardization of bioactive in gredients in over-the-counter vitamins, herbs, and supplements. In this article, we provide a comprehensive review of the efficacy, safety, and tolerability of CAM, including natural products and mind and body practices, in the treatment of hair loss. Overall, there is a need for additional studies investigating CAM for alopecia with more robust clinical design and standardized, quantitative outcomes.

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The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial

Abstract: Hair count results show a modest and sustained improvement in hair growth with daily use of a 1% pyrithione zinc shampoo over a 26-week treatment period.

Cited by 69 publications

References 16 publications

Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis – Towards a More Precise Definition of Scalp Health

Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

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