Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

Hosking, Anna-Marie; Juhász, Margit; Mesinkovska, Natasha Atanaskova

doi:10.1159/000492035

Cited by 70 publications

(73 citation statements)

References 101 publications

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“…The literature says that the use of invasomes yields long-term effects that are self-satisfactory. Today, patients also use alternative and complementary therapies to try to find a safe, natural, and efficient cure for hair restoration [52]. In this context, the FDA approved the finasteride, a 5α reductase inhibitor, and now this is commonly preferred for the treatment of alopecia.…”

Section: Used In Alopecia Treatmentmentioning

confidence: 99%

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Nangare

Dugam

2020

Futur J Pharm Sci

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Background Scientists are constantly looking for the introduction of unique drug delivery systems for the existing drug molecule. Since the skin is one of the primary and essential organs of the human body, it needs successful research development for the delivery of the drug. While the skin is assumed a human body’s multifunctional organ, it has minimal permeability across the stratum corneum (SC). Since this is an influential barrier for the active agent, several carrier platforms to surmount this obstacle have been created. Invasomes are the liposomal vesicles, which incorporate small quantities of ethanol and terpenes or a mixture of terpenes, as potentials for improved penetration of the skin. The rate of penetration of invasomes through the skin is significantly greater than that of liposomes and ethosomes. Invasomes focus on providing a series of benefits namely enhanced drug effectiveness, increased conformity, and ease for patients. Main body The present article portrays insights of invasomes which include composition and preparation methods of invasomes. The article gives a brief review of the penetration mechanism, synthesis process, and characterizations of invasomes. The article gives a point by point audit about pharmaceutical applications, viz. anticancer, antihypertensive, anti-acne, vitamin analog, anticholinergic, antioxidant, etc. The pharmacokinetic properties of invasomes have also been described. Conclusion The key goal of an invasome-based delivery system is not only to strengthen the efficacy and safety of the drug but also to dramatically increase patient conformity and the therapeutic value to a significant extent. The delivery of drugs via the skin membrane in advanced drug delivery systems is a fascinating fact. Many pharmaceutical studies have shown that plentiful drug molecules are less soluble, have less bioavailability and stability, have less penetration, etc. Therefore, a new form of dosage with exceptional characteristics like invasomes can be created. Graphical abstract

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Section: Used In Alopecia Treatmentmentioning

confidence: 99%

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Nangare

Dugam

2020

Futur J Pharm Sci

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“…Vitamins, amino acids and minerals being very common options. 20 Biotin has been linked to hair loss but unfortunately there are no clinical trials correlating efficacy of biotin supplementation with hair growth. 21 Further, clinicians advise caution in using biotin supplement for hair loss as it can interacts with troponin, N-terminal pro-brain natriuretic peptide tests, and interfere with thyrotropin and thyroid hormone assays, leading to misdiagnosis of thyroid levels and cardiac syndromes.…”

Section: Introductionmentioning

confidence: 99%

“…Further, people often turn towards herbal extracts, which have lower side effects and better compliance. 20 Hair serum (investigational product) is a hair growth formulation containing Saberry ® (Emblica officinalis extract, synonymous with Phyllanthus emblica, more commonly known as Amla, standardized for 10% β-glucogallin), Cococin™ (freeze-dried Cocos nucifera water solids) and PeptiSeLect ® (γ-L-Glutamyl-L-selenomethionine, CAS no. 879546-05-1) in the form of water-soluble powder as active ingredients.…”

Section: Introductionmentioning

confidence: 99%

<p>Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall</p>

Majeed¹,

Majeed²,

Nagabhushanam³

et al. 2020

CCID

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Background: Hair fall is a widespread problem among all genders, ages, and ethnicity with both physical and psychological effects. Objective: This clinical study was designed to evaluate the efficacy and safety of a hair serum formulation containing amla extract, freeze-dried coconut water, and the micronutrient selenium along with sandalwood odorant and peanut shell extract in healthy male and female volunteers with hair fall. Methods: A total of 42 subjects were enrolled and completed the study and they used the test product daily for 90 days. TrichoScan ® was used to evaluate the efficacy of the test product for improving hair growth rate, hair density, anagen hair, telogen hair, and the density of vellus and terminal hair. Hair thinning and hair fall reduction were compared to its basline by both dermatologists and subject self-assessment questionnaires. Result and Discussion: After 90 days of test product application, there was a significant improvement in hair growth rate (<0.0001), hair density (<0.0001), vellus hair density (<0.0001), and terminal hair density (<0.0001) in comparison to baseline. There was a significant reduction in hair fall with bulb (<0.0001) and without bulb (<0.0001), and hair thinning (<0.0001) compared to the baseline measurement. Adverse events were not recorded during the study. No skin intolerance was reported during the study, and the test product was considered dermatologically safe to use.

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“…Nutraceuticals have been hitherto shown to be safe and effective treatment options, so that an increasing number of reports have focused on natural products among nutritional and antioxidant therapies as alternatives for hair loss treatment. Nonetheless, few of these have clinically proved to be effective [38]. In this context, recent preclinical evidence and clinical trials have shown an Annurca apple extract (AMS) as a nutraceutical able to effectively counteract adult baldness and patterned hair loss caused by various factors, including androgenetic and metabolic ones.…”

Section: Discussionmentioning

confidence: 99%

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

et al. 2019

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Hair disorders may considerably impact the social and psychological well-being of an individual. Recent advances in the understanding the biology of hair have encouraged the research and development of novel and safer natural hair growth agents. In this context, we have previously demonstrated-at both preclinical and clinical level-that an Annurca apple-based dietary supplement (AMS), acting as a nutraceutical, is endowed with an intense hair-inductive activity (trichogenicity), at once increasing hair tropism and keratin content. Herein, in the framework of preclinical investigations, new experiments in primary human models of follicular keratinocytes and dermal papilla cells have been performed to give an insight around AMS biological effects on specific hair keratins expression. As well as confirming the biocompatibility and the antioxidant proprieties of our nutraceutical formulation, we have proven an engagement of trichokeratins production underlying its biological effects on human follicular cells. Annurca apples are particularly rich in oligomeric procyanidins, natural polyphenols belonging to the broader class of bioflavonoids believed to exert many beneficial health effects. To our knowledge, none of the current available remedies for hair loss has hitherto shown to stimulate the production of hair keratins so clearly.

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Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

Cited by 70 publications

References 101 publications

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

<p>Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall</p>

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

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