The effects of meldonium on microrheological  abnormalities of erythrocytes in  rats  with  obesity : An experimental study

Kulikov, Evgeny Vladimirovich; Zavalishina, Svetlana Yuryevna; Vatnikov, Yury Anatolyevich; Seleznev, S.B.; Паршина, Валентина; Voronina, Yuliya Yurevna; Попова, И. А.; Бондарева, И. Б.; Petrukhina, Olesia Anatolyevna; Troshina, Natalya Igorevna; Glagoleva, T

doi:10.15562/bmj.v9i2.1150

Cited by 12 publications

(5 citation statements)

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“…Hematological parameters are now considered important markers of the status of a living organism [12]. In view of their serious biological significance, to maintain homeostasis, it is necessary to continue their detailed study in different species of productive animals throughout ontogeny [13].…”

Section: Discussionmentioning

confidence: 99%

The severity of platelet activity in young cattle of the Kholmogory breed at the end of early ontogenesis

Vorobyeva

2023

E3S Web Conf.

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Of great scientific interest is the assessment of the functionality of platelets in dairy calves at the end of early ontogenesis. 44 healthy calves of the Kholmogory breed were observed, obtained from completely healthy cows after their 2nd-3rd pregnancy. During the observation period, the young animals developed an acceleration of the process of platelet aggregation in vitro. This was accompanied in calves by an increase in the number of activated platelets in the blood and the number of their aggregates of different sizes. An increase in the functionality of platelets occurred in calves during the phase of plant nutrition due to an increase in the amount of all adenosine phosphates, an increase in the synthesis of thromboxane in them, an increase in the content of actin and myosin in them, and an intensification of their self-assembly in the case of the participation of platelets in hemostasis. The increase in hemostatic capabilities noted in calves of the Kholmogory breed is of great importance for the success of their growth and development processes during the phase of plant nutrition.

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Section: Discussionmentioning

confidence: 99%

The severity of platelet activity in young cattle of the Kholmogory breed at the end of early ontogenesis

Vorobyeva

2023

E3S Web Conf.

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“…The ongoing scientific research is increasingly aimed at studying in detail the main stages of the implementation of aging and the processes of formation of age-related pathology with a deep consideration of the mechanisms of gerontogenesis on various models (Klebanov et al, 2019). Modern researchers attach particular importance to monitoring various parameters of blood cells (Kulikov et al, 2020) and especially the most numerous group -erythrocytes (Zavalishina et al, 2018) in different conditions of the body (Zavalishina et al, 2019) and of course in the course of aging (Vakhtin, 2009). The significance of these studies is that aging affects the state of all cells in the body, as a rule, leading to a weakening of their work, with the occurrence of dysfunctions, and sometimes pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Physiological Features of Erythrocytes in the Aging Organism

Tkacheva¹,

Медведев²,

Vorobyeva³

et al. 2023

J Biochem Technol

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The progression of aging affects various blood parameters, which can weaken the viability of the body. Clarification of various aspects of this process requires additional observations, especially with the use of animals. The study was conducted on 43 healthy outbred male rats aged 24 months. Also, 32 healthy outbred male rats 3 months old, which formed the control group, were taken under observation. The examined 24-month-old rats showed standard aging phenomena. In their erythrocytes, there was an increase in lipid peroxidation caused by a weakening of the activity of their antioxidant defense. In the blood of two-year-old rats, there was a decrease in the level of erythrocyte-discocytes. This was accompanied in them by an excess content of erythrocytes in the blood, which had a changed shape to varying degrees. In rats of the older group, erythrocyte aggregation was increased, as indicated by an increase in the numberof erythrocytes that entered the aggregates in the blood and an increase in the number of most erythrocyte aggregates with a decrease in the level of free erythrocytes. For two-year-old rats, low content of erythrocytesdisconcytes in the blood and an excess number of erythrocytes with a modified shape, as well as an increase in their aggregation, are characteristics. An important reason for these changes is the weakening of the antioxidant protection of erythrocytes, leading to a pronounced activation of lipid peroxidation in them.

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“…Their influence provides a number of changes in the body, some of which have a positive effect, and some of which have a clearly negative effect. These effects have been monitored in humans [4], in productive animals [5] and in non-productive living organisms [6], as well as in different cell populations [7].…”

Section: Introductionmentioning

confidence: 99%

The influence of lead ions, cationic synthetic surfactants and their combinations on the pigment composition of tissues of plant organisms in water bodies Ceratophyllum demersum and Egeria densa

Makurina,

Goryacheva,

Medvedev

et al. 2023

E3S Web of Conf.

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The mass of man-made chemical elements entering water bodies along with wastewater is gradually increasing, causing a lot of negative consequences. Plant organisms of water bodies are among the first to experience the effects of any anthropogenic pollutants and especially heavy metals and surfactants, the amount of which increases in the water of rivers and lakes. Changes in the ratio of the pool of green and yellow enzymes in aquatic plants are considered as a reliable diagnostic indicator of the development of disorders in plant cells due to technogenic influences. Changes in the content of photosynthetic pigments in plants of two species (Ceratophyllum demersum and Egeria densa) were monitored when they were exposed to very common technogenic substances (lead ions and a solution of cationic synthetic surfactants). The changes found in the quantitative content of photosynthetic pigments in aquatic plants are caused by the appearance and development of stress and some adaptation to it. Under these conditions, the structures of proteins and lipids of thylakoid membranes change, the level of ATP decreases, free radical processes are activated and the intensity of photosynthesis is inhibited. Thus, the action of lead ions, a solution of cationic synthetic surfactants, and especially their combination have a very negative effect on the tissues of Ceratophyllum demersum and Egeria densa, which is expressed in a change in the content of photosynthetic pigments and their ratio.

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The effects of meldonium on microrheological abnormalities of erythrocytes in rats with obesity : An experimental study

Cited by 12 publications

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The severity of platelet activity in young cattle of the Kholmogory breed at the end of early ontogenesis

The severity of platelet activity in young cattle of the Kholmogory breed at the end of early ontogenesis

Physiological Features of Erythrocytes in the Aging Organism

The influence of lead ions, cationic synthetic surfactants and their combinations on the pigment composition of tissues of plant organisms in water bodies Ceratophyllum demersum and Egeria densa

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