The effects of medium-strength electric impulses on human blood

Filipič, Bratko; Kovacs, Kristine; Somogyvári, Ferenc; Ihan, Alojz; Ocsovszky, I.; Koren, Simon; Tóth, Szabolcs

doi:10.1016/s0302-4598(00)00079-9

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Therefore, we named them "interferon-like molecules." In our experiments, we also found [14] that medium-strength square-wave impulses of direct ionic current (DC) can result in a short-term direct antiviral resistance to virus infections and in a consequence to alter the membrane properties of the target cells [15]. We therefore decided to study the changes in the expression of membrane-bound surface marker molecules that are on the surface of the immune competent cells in the human blood [16][17][18].…”

Section: Introductionsupporting

confidence: 52%

Square-Wave Electric Impulses of 10 ms and 100 V/cm of Field Force, Produced by PGen-1 Impulse Generator Device, Affect the Proliferation Patterns of Different Animal Cells

Filipič¹,

Gradišnik²,

Kovacs³

et al. 2020

Electromagnetic Field Radiation in Matter

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Section: Introductionsupporting

confidence: 52%

Square-Wave Electric Impulses of 10 ms and 100 V/cm of Field Force, Produced by PGen-1 Impulse Generator Device, Affect the Proliferation Patterns of Different Animal Cells

Filipič¹,

Gradišnik²,

Kovacs³

et al. 2020

Electromagnetic Field Radiation in Matter

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“…It should be noted that blood circulation through blood vessels and capillaries is the basis of the functioning of the human body, and a change in the electrohydrodynamics of blood in a pulsed electric field can lead to various pathologies. In this way, pulsed electric fields of medium intensity (~100 V/cm) stimulate blood coagulation, as was demonstrated in [8]. Therefore, this effect should be taken into account in the development of hemodynamic models.…”

Section: Discussionmentioning

confidence: 91%

“…Moreover, taking into account the fact that living systems themselves generate electric fields and pulses, whereas external pulsed electric fields, in their turn, also affect living systems and enzymes [8][9][10], the data obtained in the present study can be interesting for use in modeling pathological processes in human body upon the impact of pulsed electric fields: for instance, in the development of hemodynamic models.…”

Section: Introductionmentioning

confidence: 99%

Influence of a Pulsed Electric Field on Charge Generation in a Flowing Protein Solution

et al. 2018

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It is known that a charge is generated in water and protein solutions upon their motion; this phenomenon is also observed in analytical systems for atomic force microscopy (AFM)-based fishing. At that, the efficiency of protein fishing correlates with the value of charge, generated upon the motion of the analyzed solution. Earlier, we demonstrated that a pulsed electric field can well be used for the enhancement of the efficiency of AFM-based fishing of low-abundant protein. In this paper, we have demonstrated the influence of a pulsed electric field on the stimulation of the electric charge generation in a solution of low-abundant proteins observed in the injector part of an AFM-based fishing system at 23 • C and 38 • C. Taking this effect into account is important for the development of novel highly sensitive flow-based diagnostic systems, as well as for the development of models describing the influence of a pulsed electric field on pathological processes in the body, hemodynamics, and physicochemical properties of solutions.

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Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin

2006

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

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Be deu tung der Be stim mung von Lym pho zy ten-Sub po pu latio nen in der Um welt me di zin Mit tei lung der Kom mis si on "Me tho den und Qua li täts si che rung in der Um welt me di zin" Bundesgesundheitsbl -GesundheitsforschGesundheitsschutz 2006 · 49:468-484 DOI 10.1007/s00103-006-1248 Ein lei tungUm welter kran kun gen wer den im mer wie der mit Al te ra tio nen im mu no lo gischer Pro zes se in Ver bin dung ge bracht [2]. In den letz ten Jah ren stan den im Focus des In ter es ses mög li che Aus wir kungen um welt me di zi ni scher Ex po si tio nen auf die re la ti ven An tei le von Lym pho zyten-Sub po pu la tio nen. De ren An a ly se mittels Durch fluss zy to me trie an hand spe zi fischer Ober flä chen mar ker ist heu te -noch vor dem Lym pho zy ten trans for ma ti ons test (LTT) und der Be stim mung von Zy to kinen -die Haupt me tho de der im mu no logi schen zel lu lä ren Di ag nos tik (. Abb. 1) und hat da her auch in die Di ag nos tik von Um welter kran kun gen Ein gang ge fun den [3]. Schon lan ge ist be kannt, dass die Lympho zy ten in Un ter grup pen ein ge teilt werden müs sen (T-, B-und na tür li che Kil lerzel len), aber erst seit dem nach ge wie sen wur de, dass sie durch de fi nier te Ober flä-chen mo le kü le cha rak te ri siert sind, war es mög lich ge wor den, sie mit tels aus ge feilter Me tho den wie der Durch fluss zy to metrie zu be stim men. Ver än de run gen in der An zahl ein zel ner Sub po pu la tio nen kann man vor al lem bei Im mun de fek ten, Leukämi en, Au toim mun-und all er gi schen Erkran kun gen so wie bei Man gel-/Stoff wechse ler kran kun gen be obach ten [4,5,6]. Beson ders bei der Klas si fi zie rung von Leukämi en kommt die ser Me tho de große Bedeu tung zu.Auf den Stel len wert der Be stim mung von Lym pho zy ten-Sub po pu la tio nen bei um welt me di zi ni schen Fra ge stel lun gen soll in die ser Stel lung nah me ein ge gangen wer den, un ter be son de rer Be rück-sich ti gung der Ein flüs se von che mi schen Sub stan zen und phy si ka li schen Fak to ren. Auf bio lo gi sche Agen ti en (z. B. Schim melpil ze) wird hier nicht ein ge gan gen, da diese das The ma wei te rer Ab hand lun gen der o. g. Kom mis si on des RKI sein sol len. CD-No men kla turZel len be sit zen Ober flä chen mo le kü le, die über mo no klo na le An ti kör per iden tifi ziert und da mit auch be stimm ten Zellent wick lun gen zu ge ord net wer den kön-nen. Mo no klo na le An ti kör per, die gleiche Ober flä chen struk tu ren er ken nen, wer den in in ter na tio na len Work shops einem "Clus ter of Dif fe ren tia ti on" (CD) zuge ord net. Dies ver ein facht die Klas si fi zierung von Mo le kü len, die in ver schie de nen Fach dis zi pli nen mit un ter schied li chen Primär na men be nannt wer den. Mit der 8. Revi si on wur den wei te re Clus ter auf ge nommen, wo mit -bei Ver bleib von frei en Posi tio nen für er war te te zu sätz li che Mo lekü le ein zel ner Mo le kül grup pen -be reits CD339 er reicht wur de (8th In ter na tio nal Work shop and Con fe rence on Hu man Leuko cy te Dif fe ren...

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The effects of medium-strength electric impulses on human blood

Cited by 5 publications

References 19 publications

Square-Wave Electric Impulses of 10 ms and 100 V/cm of Field Force, Produced by PGen-1 Impulse Generator Device, Affect the Proliferation Patterns of Different Animal Cells

Square-Wave Electric Impulses of 10 ms and 100 V/cm of Field Force, Produced by PGen-1 Impulse Generator Device, Affect the Proliferation Patterns of Different Animal Cells

Influence of a Pulsed Electric Field on Charge Generation in a Flowing Protein Solution

Bedeutung der Bestimmung von Lymphozyten-Subpopulationen in der Umweltmedizin

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