The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

Öztosun, Muzaffer; Akgül, Emin Özgür; Çakır, Erdinç; Çaycı, Tuncer; Uysal, Bülent; Ogur, Recai; Özcan, Ayhan; Özgürtaş, Taner; Güven, Ahmet; Korkmaz, Ahmet

doi:10.3109/0886022x.2012.692752

Cited by 12 publications

(14 citation statements)

References 35 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In animal models, it had been already demonstrated that ozone therapy could reduce oxidative stress in I/R injury of different organs, such as heart, liver and kidney. [16][17][18] And our in vitro results were in accordance with those of in vivo. We found that kidney cells subjected to H/R caused an elevation of oxidative stress accompanied by increased MDA production and LDH leaking ratio, and reduction in SOD activities.…”

Section: Discussionsupporting

confidence: 87%

The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells

et al. 2014

View full text Add to dashboard Cite

Ozone (O3) has been viewed as a novel treatment for different diseases in these years and oxidative stress and apoptosis play a key role in the pathogenesis of kidney diseases including renal ischemia and reperfusion (I/R). In the present study, we investigated the role of ozone oxidative preconditioning (OzoneOP) in attenuating oxidative stress and apoptosis in a hypoxia/reoxygenation (H/R) injury model using rat kidney cells. We induced H/R injury in kidney cells treated with or without OzoneOP. Oxidative stress parameters such as superoxide dismutase (SOD), malondialdehyde (MDA) and lactate dehydrogenase (LDH) were determined, as well as some apoptotic proteins. We observed that oxidative stress and apoptosis were increased in H/R group compared to OzoneOP group; however, these changes were significantly decreased by the treatment with OzoneOP. We concluded that OzoneOP can protect the kidney cells against H/R injury and its mechanism may be through the reduction of oxidative stress and apoptosis.

show abstract

Section: Discussionsupporting

confidence: 87%

The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Degeneration in the germinal epithelium, spermatogonia, and spermatids seen in the I/R group was prevented by taurine and/or ozone therapy applications, particularly in the taurine + ozone + I/R group. This protective effect of ozone therapy was previously shown in experimental renal I/R studies (19,20). However, to the best of our knowledge, the present study is the first study about the protective effect of ozone therapy in a testicular I/R model in adult rats.…”

Section: Discussionmentioning

confidence: 35%

Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model

Aydos¹,

Başar²,

Kul³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: To investigate the effect of ozone and/or taurine treatment comparatively on testicular damage due to ischemia/ reperfusion (I/R) injury in an experimental torsion model in rats.Materials and methods: Adult Wistar rats with and without torsion/detorsion were used. In order to monitor the effect of ozone and/ or taurine treatment on testicular damage due to I/R injury, following histopathological investigation apoptotic indexes were scored by TUNEL method. Moreover, tumor necrosis factor receptor 1 (TNFR1), caspase 3, caspase 8, endothelial nitric oxide synthase (eNOS), tumor necrosis factor alpha (TNFα), and cytochrome C immunostainings were performed and the levels of malondialdehyde, glutathione peroxidase, superoxide dismutase, catalase, total sulfhydryl, and nitric oxide were determined in the testicular tissue.Results: Intraperitoneal ozone and/or taurine treatment prevented both histopathological damage and increase in the apoptotic index. Torsion did not exert an effect on the levels of TNFα and cytochrome C. Ozone and/or taurine treatment prevented increases in TNFR1, caspase 3, and caspase 8. The level of oxidative stress markers was unchanged. The increases in NO level and eNOS expression were prevented by ozone and/or taurine treatment in I/R groups. Conclusion:Using ozone therapy and/or taurine before reperfusion may be a solution for germ cell degeneration resulting from testicular torsion and related infertility.

show abstract

“…Other studies have shown that O 3 can activate the antioxidant system, decrease tissue hypoxia, and increase the host immunity and characteristics of microcirculation and general health status of the exposed population (Elvis and Ekta, 2011). The protective properties of non-toxic dose exposure to O 3 on health outcomes including cardiovascular complications, liver injuries, renal injuries, diabetes and its related complications, and radiation induced toxicity have been documented (Delgado-Roche et al, 2013; Ajamieh et al, 2002; Gul et al, 2012; Oztosun et al, 2012; Al-Dalain et al, 2001; Gultekin et al, 2013). However, we can only speculate that our findings reflect negative association of term LBW with O 3 exposure.…”

Section: Discussionmentioning

confidence: 99%

The effects of air pollution on adverse birth outcomes

Roussos-Ross

et al. 2014

Environmental Research

155

View full text Add to dashboard Cite

Background Air pollution has been shown to have adverse effects on many health outcomes including cardiorespiratory diseases and cancer. However, evidence on the effects of prenatal exposure is still limited. The purpose of this retrospective cohort study is to evaluate the effects of prenatal exposure to air pollutants including particulate matter with aerodynamic diameter less than 2.5 micrometer (PM2.5) and ozone (O3) on the risk of adverse birth outcomes (ABOs) including term low birth weight (LBW), preterm delivery (PTD) and very PTD (VPTD). Methods Singleton births from 2004–2005 in Florida were included in the study (N=423,719). Trimester-specific exposures to O3 and PM2.5 at maternal residence at delivery were estimated using the National Environmental Public Health Tracking Network data, which were interpolated using Hierarchical Bayesian models. Results After adjustment for potential confounders such as demographics, medical and lifestyle factors PM2.5 exposures in all trimesters were found to be significantly and positively associated with the risk of all ABOs. Second-trimester exposure had the strongest effects. For an interquartile range (IQR) increase in PM2.5 during the second trimester, the risk of term LBW, PTD and VPTD increased by 3% [95% confidence interval (CI): 1–6%)], 12% (11–14%) and 22% (18–25%), respectively. O3 was also found to be positively associated with PTD and VPTD with the strongest effects over the whole pregnancy period [3% (1–5%) for PTD and 13% (7–19%) for VPTD for each IQR increase]. However, O3 was observed to have protective effects on term LBW. Results were consistent for multi-pollutant models. Conclusion PM2.5 has consistent adverse effects on ABOs whereas O3 has inconsistent effects. These findings warrant further investigation.

show abstract

The Effects of Medical Ozone Therapy on Renal Ischemia/Reperfusion Injury

Abstract: Our results clearly showed that OT has beneficial effect to protect kidney against IRI. The serum neopterin levels might be used as a marker to detect the degree of renal IRI.

Cited by 12 publications

References 35 publications

The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells

The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells

Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model

The effects of air pollution on adverse birth outcomes

Contact Info

Product

Resources

About