The effects of LPS on the cellular composition of the splenic white pulp in responder C3H/He and non-responder C3H/HeJ mice

Groeneveld, P. H. P.; Koopman, Gerrit; Rooijen, Nico van

doi:10.1007/bf02912096

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…In the present study, the periarterial lymphatic sheath of the spleen of the LPS group showed aggregation and thinning in shape, with a decrease in the quantity of lymphocytes. The histological changes of spleen demonstrate that the number of T lymphocytes in the inner periarterial lymphatic sheath decreases markedly after LPS injection, which is consistent with the results of previous studies (Groeneveld et al, 1985;Castro et al). The reduction of intrasplenic T cells may be due to the increase of apoptosis which was related to LPS-activated B cells.…”

Section: Discussionsupporting

confidence: 90%

Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

et al. 2014

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SUMMARY:The histological changes in the spleen and the immunohistochemical expression of visfatin in lipopolysaccharidestimulated piglets are reported to examine the relation between visfatin and inflammation. The results are as follows: (1) After LPS treated, the spleen displayed thicker capsules and trabecula, the thinner periarterial lymphatic sheath, and the more expandable splenic sinusoid, with an increase in the number of splenic nodules, lymphocytes, ellipsoids of the marginal zone, red blood cells and macrophagocytes. (2) Visfatinpositive cells were mainly distributed in the red pulp of the spleen, with less in splenic nodules and periarterial lymphatic sheath. In the LPStreated group, the signal intensity and quantity of the visfatin-positive cells were significantly higher in the red pulp and the ellipsoids of the spleen (P<0.01), whereas lower in the periarterial lymphatic sheath. These results indicate that LPS stimulation induces inflammation, causing the histological changes of the piglet spleen and activating humoral immune response. Moreover, variation of visfatin in the spleen suggests that lymphocytes and macrophages are the potent source of visfatin which participates in the humoral immune response in the inflammation.

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Section: Discussionsupporting

confidence: 90%

Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

et al. 2014

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In vivo effects of toxic and detoxified endotoxin alone or in combination with muramyl dipeptide on lymphoid and non-lymphoid cells in the spleen of Meth A sarcoma-bearing mice

Kuper¹,

Groeneveld

Bloksma

1986

Virchows Archiv B Cell Pathol

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Effects of Interferon on the Lymphocyte Subset in the Blood and Lymphoid Organs in Mice

Kawasaki¹,

Moriyama²,

Hirao³

et al. 1986

Journal of Interferon Research

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The effects of mouse interferon-alpha/beta (MuIFN) or poly(I):poly(C) injection on the lymphocytes in the blood, thymus, and spleen of C3H/HeN mice were examined. A single injection of MuIFN (2 X 10(6) to 2 X 10(7) IU/kg of MuIFN) or poly(I):poly(C) (0.12-1.2 mg/kg) caused a significant lymphocytopenia without any evidence of direct cytotoxic effects on lymphocytes in the blood or lymphoid organs, a significant decrease in the number of T cells both in the thymus and spleen along with a significant increase in the number of non-T cells in the splenic white pulp, and a differential decrease in the number of blood T-cell subsets ("suppressor/cytotoxic" subset was decreased continuously whereas "helper" subset only transiently). The differential effect on T-cell subsets could explain the complicated effects of IFN on the cell-mediated immune response.

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The effects of LPS on the cellular composition of the splenic white pulp in responder C3H/He and non-responder C3H/HeJ mice

Cited by 4 publications

References 19 publications

Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

Distribution and Expression of Visfatin-Positive Cells in the Spleen of Lipopolysaccharide-Stimulated Piglets

In vivo effects of toxic and detoxified endotoxin alone or in combination with muramyl dipeptide on lymphoid and non-lymphoid cells in the spleen of Meth A sarcoma-bearing mice

Effects of Interferon on the Lymphocyte Subset in the Blood and Lymphoid Organs in Mice

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