The effects of low molecular weight dextran infusion in humans

Hemodynamic findings in patients with intravascular red cell aggregation

“…The finding may indicate that dextran has a specific pharmacological effect beside the plasma volume expanding effect. The same finding is seen in normal subjects after dextran infusion (7,10,17).…”

“…The marked increase in right atrial and PCV pressures together with an increased cardiac output after dextran in-fusion are described earlier (7,10,17).…”

Influence of Blood Viscosity on Blood Flow and the Effect of Low Molecular Weight Dextran

“…Though this was originally suggested by Poiseuille (1846), based on his studies of Newtonian fluids in rigid tubes, this relationship has never been investigated directly in humans. Gelin et al (1961), Carey et al (1965, and Gianelli et al (1965) measured the effect of various intravenous infusions on blood flow but did not correlate the changes in blood flow with the changes in viscosity or P.C.V.…”

Effect of Low Molecular Weight Dextran on Acrocyanosis and Scleroderma

“…Flemma [6] found no preventive effect of LMWD on bio-clcctrically induced thromboses in dogs. Giannelli et al [11] found no effect of LMWD infusion on circulatory, ventilatory and acid-base data obtained during right heart catheterization.…”