Effect of Low Molecular Weight Dextran on Acrocyanosis and Scleroderma

Zackheim, Herschel S.; Farber, Emmanuel; Aschheim, Emil

doi:10.1159/000253904

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…98 A trial of low molecular weight dextran to improve the rheologic properties of blood in acrocyanosis showed no effect. 166 In most cases, vasoactive drugs can be avoided. Unlike Raynaud’s patients, some patients with acrocyanosis were reported to improve with the use of beta-blockers, presumably due to blocking of peripheral catecholamine actions; however, this seems unlikely and we were unable to verify this singular report.…”

Section: Treatmentmentioning

confidence: 99%

Acrocyanosis: The Flying Dutchman

2011

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Acrocyanosis is symmetric, painless, discoloration of different shades of blue in the distal parts of the body that is marked by symmetry, relative persistence of the skin color changes with aggravation by cold exposure, and frequent association with local hyperhidrosis of hands and feet. Described over a century ago and despite seeming familiarity, it remains a poorly understood condition that shares much in clinical presentation with other conditions characterized by skin color changes in the distal parts of the body. The diagnosis remains mostly clinical, and pathological mechanisms vary suggesting that acrocyanosis may not be a single entity. We performed an extensive literature review to summarize existing knowledge about the demographics, pathology, diagnosis, and treatment of this condition.

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Section: Treatmentmentioning

confidence: 99%