The Effects of Long-Term Herbal Treatment for Pediatric AIDS

Michio, Tani; Nagase, Mahiko; Nishiyama, Tadao; Yamamoto, Tatsutaka; Mătuşa, R

doi:10.1142/s0192415x02000065

Cited by 8 publications

(4 citation statements)

References 21 publications

(16 reference statements)

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“…The low viraemia (19,000) accounted for total reduction of HIV and total increase in CD4 count as seen in table and figure I. Tani et al (2002) reported that herbal remedies improved the quality of life paediatric infected patients with increase in CD4 count and decrease in viral load over a period of 8years therapy, α-zam reduced viral (HIV-RNA) load to undetectable level in many patients in shorter period in this study.…”

Section: Discussionsupporting

confidence: 51%

Virologic And Immunologic Outcome Of Treatment Of Hiv Infectionwith A Herbal Concoction, Α-Zam, Among Clients Seeking Herbal Remedy In Nigeria

Onifade¹,

Jewell²,

Onifade³

2010

Afr. J. Trad. Compl. Alt. Med.

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This study was to determine the effectiveness (CD4 count and viral load) of a safe herbal concoction, α-Zam used by clients seeking herbal remedy for treatment of HIV infection in Nigeria. 51 patients taking α-Zam as complementary and alternative therapy through the herbal therapist were studied for a period of 16 months. Preliminary medical and laboratory examinations using WHO and CDC criteria were done after confirmation of HIV infection by Western blotting in the nearest teaching hospitals to the residence of the patients. Regular visits were paid to the patients after commencement of the α-Zam to assess the side-effects, drug interactions, toxicity and effectiveness of the herbal remedy. There was a statistical significance (P<0.05) between pre-treatment and post-treatment CD4 count. 4 (7.8%) of the patients had average increase in CD4 count of 262±16 cell/µL, 23 (45.1%) patients with average increase 310±16 cell/µL, 16 (31.4%) patients with average increase 456±25 cell/µL and 8 (15.7%) patients with average increase 510±36 cell/µL( %) were at WHO staging

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Section: Discussionsupporting

confidence: 51%

Virologic And Immunologic Outcome Of Treatment Of Hiv Infectionwith A Herbal Concoction, Α-Zam, Among Clients Seeking Herbal Remedy In Nigeria

Onifade¹,

Jewell²,

Onifade³

2010

Afr. J. Trad. Compl. Alt. Med.

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“…The Ministry of Health of South Africa is actively promoting the use of traditional medicines with antiretroviral treatments and recommended two plants remedies which have been used for HIV/AIDS treatment: Hypoxis hemerocallidea and Sutherlandia frutescens [ 393 ]. Also, in Romania it was noticed that children with AIDS who were treated with natural herbal remedies showed a decrease in mortality rate [ 393 ]. Furthermore, in blood samples of 30 adults who used an extract of Alternanthera pungens , a significant increase of CD4 and CD8 lymphocytes was observed [ 394 ].…”

Section: Human Clinical Trialsmentioning

confidence: 99%

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

Salehi

Şener

et al. 2018

IJMS

128

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Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.

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“…For example, Scutellaria baicalensis georgi and its identified components (that is, baicalein and baicalin) have been shown to inhibit infectivity and replication of HIV 184 . Some preliminary evidence of efficacy has recently been published 185 .…”

Section: Prevention Of Cancer Progressionmentioning

confidence: 99%

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

Sagar

Wong

2008

Current Oncology

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Traditional Chinese Medicine (TCM) is a whole system containing therapeutic interventions that individually induce biomodulation at the physiologic, chemical, and molecular levels. The theory of TCM proposes a synergy between specific interventions selected as part of a care plan based on TCM diagnostic theory. Combining TCM with the modern practice of oncology seems, in conjunction with biomedical interventions (surgery, radiotherapy, chemotherapy, and pharmaceuticals), to have potential advantages through the synergy of biomodulation. Biomodulation approaches are broadly categorized as modification of tumour response and reduction of adverse effects; modulation of immunity; prevention of cancer progression; and enhancement of symptom control. Although the database of preclinical studies is rapidly expanding, good-quality clinical trials are notably scarce.Laboratory studies suggest that some herbs increase the effectiveness of conventional chemotherapy without increasing toxicity. A healthy immune system is necessary for control of malignant disease, and the immune suppression associated with cancer contributes to its progression. Many Chinese herbs contain glycoproteins and polysaccharides (among them, constituents of Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Astragalus membranaceus, Panax ginseng, and various other medicinal mushrooms) that can modulate metastatic potential and the innate immune system. Phytochemicals such as specific polysaccharides have been shown to boost the innate immune system, especially through interaction with Tolllike receptors in mucosa-associated lymphoid tissue. This intervention can potentially improve the effectiveness of new anticancer vaccines. An increase in virusassociated cancers presents a major public health problem that requires novel therapeutic strategies. A number of herbal therapies have both antiviral activity and the ability to promote immunity, possibly inhibiting the initiation and promotion of virus-associated cancers.The mechanisms learned from basic science should be applied to clinical trials both of specific interventions and of whole-system care plans that safely combine the TCM approach with the conventional biomedical model. In Western medicine, the combination of TCM herbs with drug therapies is controversial, given lack of knowledge concerning whether a drug is favourably enhanced or whether adverse effects occur. Using initial data from the preclinical studies, future clinical research needs to evaluate the combinations, some of which are showing favourable synergy.

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The Effects of Long-Term Herbal Treatment for Pediatric AIDS

Cited by 8 publications

References 21 publications

Virologic And Immunologic Outcome Of Treatment Of Hiv Infectionwith A Herbal Concoction, Α-Zam, Among Clients Seeking Herbal Remedy In Nigeria

Virologic And Immunologic Outcome Of Treatment Of Hiv Infectionwith A Herbal Concoction, Α-Zam, Among Clients Seeking Herbal Remedy In Nigeria

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

Chinese Medicine and Biomodulation in Cancer Patients—Part Two

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