The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice

Abstract

Taken together, our results indicate that lobeline attenuated nicotine withdrawal-induced depression-like behavior likely by targeting brain nAChRs, noradrenergic neurotransmission, and/or hippocampal BDNF. Thus, lobeline may have some potential to prevent smoking relapse by counteracting nicotine withdrawal-induced depression in humans.

Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests

“…#P<0.05 and ##P<0.01 compared with the nicotine (0.2 mg/kg)-administered group animals can also lead to depressive symptoms after few days or weeks (Iniguez et al 2009;Mannucci et al 2006). For example, withdrawal from chronic nicotine increased immobility time in the FST (Roni and Rahman 2014). However, it is said that nicotine administration can typically exert antidepressant effect both in human and animal studies.…”

BDNF During Withdrawal

“…The increase BDNF levels observed following methamphetamine treatment seem to be involved in a depression-like phenotype, since the immobility time of the treated animals was higher in the tail-suspension test and the forced swim test compared to control, as well as a lower sucrose preference (Ren et al, 2015). Similarly an increase in the duration of the immobility time in the forced swim test during early withdrawal was also observed following cocaine (Filip et al, 2006) and nicotine administration (Roni & Rahman, 2014). With cocaine exposure, the temporal regulation of BDNF was also studied after a single cocaine injection.…”

“…In contrast, 48 h after the end of nicotine treatment, other authors found an increase in BDNF protein levels in hippocampus and a trend toward increased pCREB (Roni & Rahman, 2014). This discrepancy may result from differences into the protocols, as Kenny used passive injections of nicotine for 7 days, whereas in the latter study it was a voluntary consumption of nicotine (mice drank nicotine solution for 21 days) (Roni & Rahman, 2014).…”

The effects of lobeline on depression-like behavior and hippocampal cell proliferation following chronic stress in mice

“…Consistent with an increase in ACh leading to stress, clinical studies showed that blockade of brain nicotinic ACh receptor (nAChR) may improve mood in depressed patients [11,12]. Recently, we have demonstrated that lobeline reduces depressionlike behavior as well as ethanol drinking behavior in mice [13][14][15][16][17][18][19]. The observations from receptor binding studies suggest that lobeline is a non-selective nAChR antagonist with high affinity for ␣4␤2 and ␣3␤2 nAChRs [20].…”