Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests

Haj‐Mirzaian, Arya; Kordjazy, Nastaran; Haj-Mirzaian, Arvin; Ostadhadi, Sattar; Ghasemi, Mehdi; Amiri, Shayan; Faizi, Mehrdad; Dehpour, Ahmad Reza

doi:10.1007/s00213-015-4004-0

Cited by 51 publications

(22 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the NMDA receptor antagonists, such as (+)-MK-801 (0.3mg/kg) and CGP 37849 (5mg/kg), improved deficits in sucrose intake under the chronic mild stress model (Papp and Moryl, 1994), indicating possible antianhedonia effects for the NMDA receptor antagonists. Taken together, it is likely that (+)-MK-801 promotes antidepressant effects in rodent models of depression (Papp and Moryl, 1994; Haj-Mirzaian et al, 2015; this study), although these data are inconsistent with a recent report from Zanos et al (2016).…”

Section: Discussioncontrasting

confidence: 99%

“…It is reported that the NMDA receptor antagonists, including ketamine (1mg/kg) and (+)-MK-801 (0.05mg/kg), are able to attenuate the depression-like phenotype seen in the early-life social isolation stress model (Haj-Mirzaian et al, 2015), suggesting involvement of the NMDA receptor in the depression-like behaviors induced in this model. Furthermore, the NMDA receptor antagonists, such as (+)-MK-801 (0.3mg/kg) and CGP 37849 (5mg/kg), improved deficits in sucrose intake under the chronic mild stress model (Papp and Moryl, 1994), indicating possible antianhedonia effects for the NMDA receptor antagonists.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Yang

Ren

et al. 2016

IJNPPY

View full text Add to dashboard Cite

Background:Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression.Methods:The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stress model were examined.Results:In the tail suspension and forced swimming tests, both stereoisomers significantly attenuated increased immobility time in susceptible mice. In the sucrose preference test, (+)-MK-801, but not (-)-MK-801, significantly enhanced reduced sucrose consumption 2 or 4 days after a single dose. However, no antianhedonia effects were detected 7 days after a single dose of either stereoisomer.Conclusions:Both stereoisomers of MK-801 induced rapid antidepressant effects in the social defeat stress model, although neither produced a long-lasting effect (7 days).

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Yang

Ren

et al. 2016

IJNPPY

View full text Add to dashboard Cite

show abstract

“…Although the reasons underlying the negative effect of ketamine are unknown, the experimental protocols (e.g., different animal models, experimental apparatus, dose of ketamine, and observational protocol) may contribute to the negative result. In addition, we did not perform the OF test after ketamine injection in the experiment 2 because the total distance, indicating the motor function in the OF test, is not affected by a single sub-anesthetic dose of ketamine in our previous studies 35, 47, 64 and other reports 46, 78 . Together, it seems that ketamine may not have beneficial effects on motor function deficits after SNI surgery.…”

Section: Discussionmentioning

confidence: 97%

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Xie

Wang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Although pain is frequently accompanied with depression, little is known about the risk factors contributing to individual differences to the comorbidity of pain and depression. In this study, we examined whether cytokines and brain-derived neurotrophic factor (BDNF) might contribute to the individual differences in the development of neuropathic pain-induced depression. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups by the data from depression-related behavioral tests. Rats with depression-like phenotype displayed higher levels of pro-inflammatory cytokines (e.g., interleukin (IL)-1β, IL-6) as well as imbalance of pro/anti-inflammatory cytokines compared with rats without depression-like phenotype and sham-operated rats. Levels of BDNF in the prefrontal cortex of rats with depression-like phenotype were lower than those of rats without depression-like phenotype and sham-operated rats. A single dose of ketamine ameliorated depression-like behaviors in the rats with depression-like phenotype. Interestingly, higher serum levels of IL-1β and IL-6 in the rat with depression-like phenotype were normalized after a single dose of ketamine. These findings suggest that alterations in the inflammatory cytokines and BDNF might contribute to neuropathic pain-induced depression, and that serum cytokines may be predictable biomarkers for ketamine’s antidepressant actions.

show abstract

“…The criteria of considering the animals as immobile included stopping the struggle and staying immobile and floating in the water. After a 2 min adaptation period, the duration of immobility was measured in the last 4 min of the experiment …”

Section: Methodsmentioning

confidence: 99%

Involvement of opioid system in antidepressant‐like effect of the cannabinoid CB₁ receptor inverse agonist AM‐251 after physical stress in mice

Ostadhadi

Haj‐Mirzaian

Nikoui

et al. 2016

Clin Exp Pharma Physio

Self Cite

View full text Add to dashboard Cite

Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251. Stress was induced by intermittent foot-shock stimulation for 30 min. Then, using the forced swimming test (FST) and tail suspension test (TST), the immobility time was measured. Results show that the immobility time was significantly prolonged in animals subjected to foot-shock stress, compared with non-stressed controls (P < 0.01). Also, the serum corticosterone level was significantly increased after stress induction (P < 0.001). Administration of AM-251 (0.5 and 0.3 mg/kg, intraperitoneally (i.p.)), significantly decreased the immobility time of stressed mice in the FST (P < 0.001 and P < 0.01, respectively) and TST (P < 0.01 and P < 0.05, respectively). The lowest dose of AM-251 (0.1 mg/kg), naltrexone (0.3 mg/kg), and morphine (1.0 mg/kg) did not show any significant effect on stressed animals (P > 0.05). Co-administration of AM-251 with sub-effective dose of naltrexone decreased the effective dose of this cannabinoid inverse agonist, to 0.1 mg/kg (P < 0.01). On the other hand, administration of the sub-effective dose of morphine reversed the anti-immobility effect of AM-251 (0.5 mg/kg; P < 0.001). In conclusion, the present study for the first time reveals the possible role of opioid signalling in the antidepressant-like properties of AM-251 in a foot-shock stress model.

show abstract

Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests

Abstract: Our study has for the first time confirmed that the antidepressant-like effect of nicotine on mice is NMDA-mediated, and nicotine presumably exerts this effect by antagonizing the glutamatergic NMDA receptors.

Cited by 51 publications

References 72 publications

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Involvement of opioid system in antidepressant‐like effect of the cannabinoid CB₁ receptor inverse agonist AM‐251 after physical stress in mice

Contact Info

Product

Resources

About

Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests

Abstract: Our study has for the first time confirmed that the antidepressant-like effect of nicotine on mice is NMDA-mediated, and nicotine presumably exerts this effect by antagonizing the glutamatergic NMDA receptors.

Cited by 51 publications

References 72 publications

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Involvement of opioid system in antidepressant‐like effect of the cannabinoid CB1 receptor inverse agonist AM‐251 after physical stress in mice

Contact Info

Product

Resources

About

Involvement of opioid system in antidepressant‐like effect of the cannabinoid CB₁ receptor inverse agonist AM‐251 after physical stress in mice