The effects of lithium on muscle contractile function in humans

Tarnopolsky, Mark A.; Hicks, Audrey L.; Winegard, Karen J.

doi:10.1002/(sici)1097-4598(199603)19:3<311::aid-mus5>3.0.co;2-g

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…described by Edwards et al (8) and as shown by our laboratory in the past (31). Twitch contraction characteristics.…”

Section: Resultsmentioning

confidence: 84%

“…A silver strip ground electrode (6 ϫ 50 mm) was placed between the cathode and the G 1 electrode. The lower leg was then firmly secured to a custommade dynamometer with the knee angle at 90°and the ankle at 10°of plantar flexion, as previously described (31).…”

Section: Subjectsmentioning

confidence: 99%

“…The mechanical data included PTT, MVC, and TETT, whereas the electrical data included the M-wave amplitude. The amplitude was measured from the negative to the positive peak (31).…”

Section: Subjectsmentioning

confidence: 99%

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Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers

Tarnopolsky¹,

Cupido

2000

Journal of Applied Physiology

170

151

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The mechanism of action underlying the ergogenic effect of caffeine is still unclear. Caffeine increases the force of muscular contraction during low-frequency stimulation by potentiating calcium release from the sarcoplasmic reticulum. Studies have also suggested an enhancement of lipid oxidation and glycogen sparing as potential mechanisms. Given that several studies have found an ergogenic effect of caffeine with no apparent metabolic effects, it is likely that a direct effect upon muscle is important. Twelve healthy male subjects were classified as habitual (n = 6) or nonhabitual (n = 6) caffeine consumers based on a 4-day diet record analysis, with a mean caffeine consumption of 771 and 14 mg/day for each group, respectively. Subjects were randomly allocated to receive caffeine (6 mg/kg) and placebo (citrate) in a double-blind, cross-over fashion approximately 100 min before a 2-min tetanic stimulation of the common peroneal nerve in a custom-made dynamometer (2 trials each of 20 and 40 Hz). Tetanic torque was measured every 30 s during and at 1, 5, and 15 min after the stimulation protocol. Maximal voluntary contraction strength and peak twitch torque were measured before and after the stimulation protocol. Caffeine potentiated the force of contraction during the final minute of the 20-Hz stimulation (P<0.05) with no effect of habituation. There was no effect of caffeine on 40-Hz stimulation strength nor was there an effect on maximal voluntary contraction or peak twitch torque. These data support the hypothesis that some of the ergogenic effect of caffeine in endurance exercise performance occurs directly at the skeletal muscle level.

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“…described by Edwards et al (8) and as shown by our laboratory in the past (31). Twitch contraction characteristics.…”

Section: Resultsmentioning

confidence: 84%

Section: Subjectsmentioning

confidence: 99%

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Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers

Tarnopolsky¹,

Cupido

2000

Journal of Applied Physiology

170

151

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“…The interaction lithium-neuromuscular blockers was also described in psychiatric patients, with an increase in the duration of the neuromuscular blockade produced by succinylcholine and pancuronium 4,24 . Besides, it was also observed, in human skeletal muscle, a negative effect of lithium on the excitation-contraction process 15 . The responses regarding the influence of lithium on different neuromuscular blockers suggest that the mechanism of action of those blockers might not be identical.…”

Section: Discussionmentioning

confidence: 88%

“…A interação lítio-bloqueadores neuromusculares também foi descrita em pacientes psiquiátricos, tendo sido observado aumento na duração do bloqueio neuromuscular produzido pela succinilcolina e pelo pancurônio 4,24 . Adicionalmente, também foi observado em músculo esquelético de humanos, efeito negativo do lítio sobre o processo excitação-contração 15 . As diferentes respostas em relação à influência do lítio nos efeitos dos diferentes bloqueadores neuromusculares sugerem que o mecanismo de ação dos bloqueadores pode não ser idêntico.…”

Section: Discussionunclassified

Influência do lítio no bloqueio neuromuscular produzido pelo atracúrio e pelo cisatracúrio: estudo em preparações nervo frênico-diafragma de rato

Fernandes¹,

Braga²,

Braga³

et al. 2007

Rev. Bras. Anestesiol.

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RESUMOFernandes SCA, Braga AFA, Braga FSS, Loyola YCS, Souza SR, Barcelos CC -Influência do Lítio no Bloqueio Neuromuscular Produzido pelo Atracúrio e pelo Cisatracúrio. Estudo em Preparações Nervo Frênico-Diafragma de Rato. JUSTIFICATIVA E OBJETIVOS:O lítio, fármaco amplamente utilizado nos distúrbios bipolares, pode interagir com os bloqueadores neuromusculares. Os mecanismos para explicar os seus efeitos na transmissão neuromuscular e a interação com bloqueadores neuromusculares são controversos. O objetivo deste trabalho foi avaliar, em diafragma de rato, os efeitos do lítio sobre a resposta muscular à estimulação indireta e a possível interação com os bloqueadores neuromusculares. MÉTODO:Utilizaram-se ratos com peso entre 250g e 300g, sacrificados sob anestesia com uretana. A preparação nervo frênico-diafragma foi montada de acordo com a técnica descrita por Bulbring. O diafragma foi mantido sob tensão, ligado a um transdutor isométrico e submetido à estimulação indireta de 0,1 Hz de freqüência. As contrações do diafragma foram registradas em fisiógrafo. Da análise da amplitude das respostas musculares avaliaram-se: os efeitos dos fármacos: lítio (1,5 mg.mL -1 ); atracúrio (20 µg.mL -1 ) e cisatracúrio (3 µg.mL -1 ) empregados isoladamente; da associação lítio-bloqueadores neuromusculares; e do lítio no bloqueio neuromuscular produzido pelo atracúrio (35 µg.mL -1 ) e cisatracúrio (5 µg.mL -1 ). Os efeitos foram avaliados antes e 45 minutos após a adição dos fármacos. Também foram estudados os efeitos do lítio nos potenciais de membrana (PM) e potenciais de placa terminal em miniatura (PPTM). RESULTADOS:O lítio isoladamente não alterou a amplitude das respostas musculares, mas diminuiu significativamente o bloqueio neuromuscular produzido pelo atracúrio e cisatracúrio. Não alterou o PM e ocasionou aumento inicial da freqüência dos PPTM. CONCLUSÕES:O lítio empregado isoladamente não comprometeu a transmissão neuromuscular e aumentou a resistência ao efeito do atracúrio e cisatracúrio. Não mostrou ação sobre a fibra muscular, sendo que as alterações nos potenciais de placa terminal em miniatura evidenciaram ação pré-sináptica. Unitermos BACKGROUND AND OBJECTIVES:Lithium is widely used for the treatment of bipolar disorders and can interact with neuromuscular blockers. There is a controversy about the mechanisms by which it affects neuromuscular transmission and its interaction with neuromuscular blockers. The objective of this study was to evaluate, on the rat diaphragm, the effects of lithium on the muscular response and indirect stimulation, and the possible interaction with neuromuscular blockers. METHODS: Rats weighing between 250 and 300 g were sacrificed under urethane anesthesia. The phrenic nerve-diaphragm preparation was assembled according to the Bulbring technique. The diaphragm was kept under tension, connected to an isometric transducer, and submitted to indirect stimulation with a frequency of 0.1 Hz. The contractions of the diaphragm were registered on a physiograph. The analysis of the amplitu...

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A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies

1997

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Fatigue in patients with mitochondrial cytopathies is associated with decreased basal and postactivity muscle phosphocreatine (PCr). Creatine monohydrate supplementation has been shown to increase muscle PCr and high‐intensity power output in healthy subjects. We studied the effects of creatine monohydrate administration (5 g PO b.i.d. × 14 days → 2 g PO b.i.d. × 7 days) in 7 mitochondrial cytopathy patients using a randomized, crossover design. Measurements included: activities of daily living (visual analog scale); ischemic isometric handgrip strength (1 min); basal and postischemic exercise lactate; evoked and voluntary contraction strength of the dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 min); and aerobic cycle ergometry with pre‐ and post‐lactate measurements. Creatine treatment resulted in significantly (P < 0.05) increased handgrip strength, NIDFT, and postexercise lactate, with no changes in the other measured variables. We concluded that creatine monohydrate increased the strength of high‐intensity anaerobic and aerobic type activities in patients with mitochondrial cytopathies but had no apparent effects upon lower intensity aerobic activities. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1502–1509, 1997

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The effects of lithium on muscle contractile function in humans

Cited by 8 publications

References 33 publications

Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers

Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers

Influência do lítio no bloqueio neuromuscular produzido pelo atracúrio e pelo cisatracúrio: estudo em preparações nervo frênico-diafragma de rato

A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies

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