The Effects of Lithium on Calcium and Parathormone Levels: A Cross-sectional Study with Healthy Controls

Tunçel, Özlem Kuman; Akdeniz, Fisun; Özbek, Süha Süreyya; Kavukçu, Gülgün; Kocabaş, Gökçen Ünal

doi:10.5080/u23677

Cited by 2 publications

(2 citation statements)

References 15 publications

(22 reference statements)

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“…On the 7th day of the supportive treatment for lithium poisoning, TSH was 3.56 mIU/L, and this value is maintained in the ongoing follow-ups of the patient, and the patient did not receive thyroid replacement therapy. In addition, the incidence of hypercalcemia due to lithiumassociated hyperparathyroidism (LIH) was found in a wide range of 3.6-62% (22). In our case, PTH and serum calcium levels were within normal limits.…”

Section: Discussionmentioning

confidence: 54%

Ciddi Nörolojik Bulgularla Birlikte Giden Lityum Zehirlenmesi Olgusu

TUĞ,

ŞAHİN CAN,

ALTUNÖZ

et al. 2023

Balıkesir Medical Journal

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Lithium is used for the treatment of bipolar disorder and some other psychiatric disorders. Due to the narrow therapeutic range, intoxications are common. In this case, chronic lithium intoxication with severe neurological symptoms was discussed in light of the literature. A 72-year-old female patient. The patient had been receiving psychiatric treatment for 7 years with the diagnosis of unipolar depression. In the 6th month of lithium use, she was brought by her relatives with complaints of drowsiness, tremor, muscle twitching, and difficulty walking. On examination, consciousness was confused, there was no cooperation orientation and there was general rigidity, tremor, fasciculations, and ataxic gait. Vital signs; blood pressure 147/92 mmHg, heart rate 69 bpm, SpO2: 94%. The laboratory tests: lithium 2.98 mEq/L, potassium 5.8 mmol/l, sodium 129 mmol/l, creatinine 1.66 mg/dl, urea 166 mg/dl. The patient was transferred to the internal medicine clinic with the diagnosis of lithium intoxication. Lithium treatment was discontinued. On the 7th day, her neurological symptoms improved with supportive treatment, and biochemical parameters returned to normal. A lithium concentration of more than 3.5 mEq/L was defined as severe poisoning. Neurological findings are prominent in severe poisonings. Especially, geriatric population is at greater risk. In our case; age, use of three different groups of diuretics as antihypertensive treatment, and urinary tract infection were defined as factors that predispose to poisoning. In this case, it's emphasized that although the lithium blood level isn't very high, severe neurological symptoms can be seen clinically in the presence of risk factors.

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Section: Discussionmentioning

confidence: 54%

Ciddi Nörolojik Bulgularla Birlikte Giden Lityum Zehirlenmesi Olgusu

TUĞ,

ŞAHİN CAN,

ALTUNÖZ

et al. 2023

Balıkesir Medical Journal

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“…[17,18] A previous study also showed that potential deleterious conditions can be prevented by assessing PTH and calcium levels before and during lithium therapy. [19] The aim of this research was to investigate the endocrinological effects of experimental subacute lithium application at different concentrations on serum T3, T4, TSH, PTH and calcium levels and thyroid tissue and to reveal the relations between them. Our research is also important as one of the rare biochemical analyses of these hormones and histological examinations of thyroid tissue.…”

Section: Introductionmentioning

confidence: 99%

Dose Dependent Effects Of Lithium Carbonate On Rat Thyroid Hormones, Parathormon and Calcium Levels With Thyroid Tissue

Topçu¹

2020

South Clin Ist Euras

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The aim of this research was to investigate the effects of subacute use of lithium carbonate (Li 2 CO 3 ), on serum T3, T4, thyroid stimulating hormone (TSH), parathyroid hormone (PTH) and calcium (Ca) levels and thyroid tissue. In addition, this research is important as one of the rare studies in which thyroid tissue was subjected to histological examination.Methods: Thirty-two male Sprague Dawley rats were assigned into groups consisting of eight animals each, based on weight; Group 1: Sham control, Group 2: Li 2 CO 3 +25 mg/kg, Group 3: Li 2 CO 3 +50 mg/kg and Group 4: Li 2 CO 3 +100 mg/kg. Li 2 CO 3 was administered orally at varying concentrations, at 1 mL per day for 30 days. Serum samples were separated from blood obtained by intracardiac intervention. Serum T3, T4, TSH, PTH and Ca levels were measured by using an autoanalyzer and chemiluminescence. Thyroid tissue was examined under light microscopy after routine histopathological procedures.Results: T3, T4, PTH and Ca levels increased in rats treated with high-dose Li 2 CO 3 , whereas TSH levels were very low in all groups. In addition, thyroid tissue exhibited concentration-dependent histological alterations. Conclusion:Li 2 CO 3 , which was administered subacute high dose in rats, caused of increased T4 and T3 hormones levels, hyperparathyroidism and hypercalcemia in the early period. These results now need to be supported by further experimental and clinical studies.

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The Effects of Lithium on Calcium and Parathormone Levels: A Cross-sectional Study with Healthy Controls

Cited by 2 publications

References 15 publications

Ciddi Nörolojik Bulgularla Birlikte Giden Lityum Zehirlenmesi Olgusu

Ciddi Nörolojik Bulgularla Birlikte Giden Lityum Zehirlenmesi Olgusu

Dose Dependent Effects Of Lithium Carbonate On Rat Thyroid Hormones, Parathormon and Calcium Levels With Thyroid Tissue

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