Dose Dependent Effects Of Lithium Carbonate On Rat Thyroid Hormones, Parathormon and Calcium Levels With Thyroid Tissue

Abstract

The aim of this research was to investigate the effects of subacute use of lithium carbonate (Li 2 CO 3 ), on serum T3, T4, thyroid stimulating hormone (TSH), parathyroid hormone (PTH) and calcium (Ca) levels and thyroid tissue. In addition, this research is important as one of the rare studies in which thyroid tissue was subjected to histological examination.Methods: Thirty-two male Sprague Dawley rats were assigned into groups consisting of eight animals each, based on weight; Group 1: Sham control, Group 2: Li 2 CO 3 +25 mg/kg, Group 3: Li 2 CO 3 +50 mg/kg and Group 4: Li 2 CO 3 +100 mg/kg. Li 2 CO 3 was administered orally at varying concentrations, at 1 mL per day for 30 days. Serum samples were separated from blood obtained by intracardiac intervention. Serum T3, T4, TSH, PTH and Ca levels were measured by using an autoanalyzer and chemiluminescence. Thyroid tissue was examined under light microscopy after routine histopathological procedures.Results: T3, T4, PTH and Ca levels increased in rats treated with high-dose Li 2 CO 3 , whereas TSH levels were very low in all groups. In addition, thyroid tissue exhibited concentration-dependent histological alterations. Conclusion:Li 2 CO 3 , which was administered subacute high dose in rats, caused of increased T4 and T3 hormones levels, hyperparathyroidism and hypercalcemia in the early period. These results now need to be supported by further experimental and clinical studies.

Pomegranate (Punica granatum) peel alleviates lithium‐induced alterations in the thyroid gland of rats by modulating apoptosis and oxidative stress

“…LC shows five times greater concentration in the thyroid gland than in other organs (McDermott et al, 1986). LC may reduce the uptake of iodine by the thyroid gland, prevent iodotyrosinase coupling, and antagonize hormone release from the gland (Topcu, 2020). This could be attributed to the reduction of colloidal pinocytosis from the follicular lumen, which could impair colloid droplet formation (van der Vaart et al, 2021), as observed by PAS staining.…”