The Effects of Lidocaine on Canine Cerebral Metabolism and Circulation Related to the Electroencephalogram

Sakabe, Takefumi; Maekawa, Taira; Ishikawa, Toshizo; Takeshita, Hiroshi

doi:10.1097/00000542-197405000-00004

Cited by 91 publications

(26 citation statements)

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“…The destruction of microtubules by colchicine and vinblastin may be associated with an increase in the number of neurofilaments (Wisniewski, Terry & Hirano, 1970); hence, axonal flow may be blocked either by the destruction of microtubules or by the increased numbers of neurofilaments (Fink et al 1973;Byers, Fink, Kennedy, Middaugh & Hendrickson, 1974) or by the blocking of the oxidative metabolism by lidocaine, an agent frequently used in these experiments (Cullen & Haschke, 1974;Sakabe, Maekawa, Ishikawa & Takeshita, 1974;Novotny & Bianchi, 1967). Our data indicate that the increase in neurofilaments is independent of the destruction of microtubules (Table 2).…”

Section: Discussionmentioning

confidence: 99%

The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles.

Friede¹,

Ho²

1977

The Journal of Physiology

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SUMMARYAxonal transport of mitochondria was studied in frog sciatic nerves incubated in agents selected for their known or alleged effect on microtubules or axonal flow.Quantitative data on mitochondria, microtubules, neurofilaments, endoplasmic reticulum, and cross-sectional area of the axon indicate that axonal transport of mitochondria is dependent on microtubules. When more than half of the microtubules are destroyed, the axonal transport of mitochondria is diminished in proportion to the destruction of microtubules.Axonal transport of mitochondria is not related to neurofilaments and endoplasmic reticulum.Changes in the cross-sectional area of axons, even upon reduction to half the normal size, do not noticeably affect mitochondrial transport.Cyanide which blocks oxidative metabolism also blocks axonal transport of mitochondria, but analysis of fine structure indicates that cyanide is destructive to microtubules as well.

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Section: Discussionmentioning

confidence: 99%

The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles.

Friede¹,

Ho²

1977

The Journal of Physiology

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“…Genel anestezi nedeniyle oluşan öksürük, topikal veya intravenöz lidokain ile önlenebilir (47). Lidokain serebrovasküler rezistansı artırarak serebral kan akımını ve oksijen tüketimini azaltır sonuç olarak serebral basınç azalır (48,49). İntravenöz lidokainin GİB'yi de azalttığını gösteren çalışmalar mevcuttur (50,51).…”

Section: Oftalmik Cerrahide Genel Anesteziunclassified

Oftalmik cerrahide anestezi

Bor¹,

Certug²

2015

Ege Tıp Dergisi

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ÖzAnestezistler için oküler cerrahide birçok uygun anestezi tekniği mevcuttur. Günümüzde genel anestezi yöntemi bilinen temel ilaçları içermesine rağmen (intravenöz anestezikler ve inhalasyon anestezikleri, opiyoidler ve kas gevşeticiler) göz cerrahisinde daha az sıklıkla uygulanan anestezi yöntemidir. Genel anestezi; mental retarde, uyum sağlamada güçlüğü olan, yaşlı ve çocuk hastalar ile lokal anesteziyi reddeden hastalara uygulanmaktadır. Rejyonel veya genel anestezi yöntemi anestezistin deneyimine bağlıdır. Göz cerrahisi hasta grubunda artan yaş ve komorbitide, her tekniğin dikkatli yönetimini ve cerrah ile anestezistin iyi bir iletişimini gerektirir. Göz cerrahisinde uygulanan anestezi yöntemi ve yönetimi cerrahinin güvenliği ve başarısında kritik rol oynar.Anahtar Sözcükler: Oftalmik anestezi. Abstract Many anesthetic techniques are available in ocular surgery for the anestesiologists.Currently general anesthesia includes basic products (intravenous and inhalation anesthetics, opioids, and neuromuscular blockers) but less utilised in ophthalmology. General anaesthesia is indicated in debile, uncooperative or senile patients, in patients who refuse loco-regional procedures and in children. Regional or general anesthetic methods depends on the experience of the anesthetist. Increasing aging and comorbidity in the ophthalmic patient population needs careful management of each technique and therefore sufficient communication between anaesthesiologist and surgeon is essential.Ocular anesthetic techniques and managements play a critical role for the success and safety of ophthalmic surgery.

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“…At lower doses, lidocaine seems to decrease CBF, whereas at higher (preseizure) doses it has been proven to increase CBF significantly [5]. Increased cerebral oxygen metabolic rates may also increase CBF [6].…”

Section: Introductionmentioning

confidence: 99%

Influence of intravenously administered lidocaine on cerebral blood flow in a baboon model standardized under controlled general anaesthesia using single-photon emission tomography and technetium-99m hexamethylpropylene amine oxime

et al. 1993

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The baboon under general anaesthesia as a model to assess drug-induced cerebral blood flow changes (delta CBF) using single-photon emission tomography (SPET) offers great in vivo possibilities but has to comply with demands on control of anaesthesia-related influencing factors, such as PaCO2 changes. The model sought in this study and described here allows control of PaCO2, in the baboon under thiopentone anaesthesia by ventilation, and was evaluated for the functional dependence of delta CBF vs delta PaCO2, using SPET technetium-99m hexamethylpropylene amine oxime (HMPAO) and the split-dose method together with controlled ventilation. During the experiment the model was validated for normal reactivity to PaCO2 changes, and subsequently applied to investigate the mechanisms (still uncertain) of CBF increase known to follow administration of the local anaesthetic lidocaine. Six baboons received 6 mg/kg lidocaine intravenously. CBF was measured between two consecutive SPET acquisitions (split-dose method) respectively relating to HM-PAO distributions in the brain before and after the injection of lidocaine. Meanwhile the animals were maintained at constant respiratory rate and volume. The results indicate that the correlation between delta CBF and the ensuing fall in PaCO2 deviated from the baseline pattern from the model and confirmed a cerebrovascular contribution to the lidocaine-induced CBF increase. This agreed well with mean and systolic blood pressure changes and heart rate.

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The Effects of Lidocaine on Canine Cerebral Metabolism and Circulation Related to the Electroencephalogram

Cited by 91 publications

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The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles.

The relation of axonal transport of mitochondria with microtubules and other axoplasmic organelles.

Oftalmik cerrahide anestezi

Influence of intravenously administered lidocaine on cerebral blood flow in a baboon model standardized under controlled general anaesthesia using single-photon emission tomography and technetium-99m hexamethylpropylene amine oxime

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