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Bosman H, Dormehl IC, Hugo N, Redelinghuys IF, Theron JJ. The effect of intravenous administration of melatonin on cardiovascular parameters of the baboon (Pupio ursinus). J . Pineal Res. 1991: I1:179-Abstract: Melatonin (0.3 to 0.4 mgikg) dissolved in 0.5 ml dirnethylsulphoxide (DMSO) was injected i.v. into six baboons, and their cardiovascular parameters were monitored. Left ventricular end-diastolic and end-systolic volumes, stroke volume, cardiac output, and left ventricular ejection fraction were measured, using conventional radionuclide ventricuiography, and compared to normal values previously established. These parameters were also measured after an i.v. administration of only DMSO. The only statistical significant change due to melatoqin was the increase in the cardiac output and left ventricular ejection fraction. With the reduced heart rate the increase in cardiac output implies a positive inotropic action on the heart by melatonin. There are indications that DMSO possibly suppresses I cardiovascular actions of melatonin.

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A phage which attacks many motile strains of the Proteus-providence group did not replicate on aflagellate or paralysed mutants. The phage consisted of an hexagonal head, a tail and one tail fibre and resembled q~X~. Electron micrographs demonstrated adsorption of the phage to the flagellar shaft of the host and the presence of phage at the flagellar base. Some of the latter phage possessed empty heads, and we postulate that the phage injects its nucleic acid at the base. This phage and ~X~ had a slight serological relationship.