The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial

Akbari, Neda; Asadimehr, Neda; Kiani, Zahra

doi:10.1016/j.ctim.2020.102401

Cited by 17 publications

(26 citation statements)

References 19 publications

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“…Five different types of herbal medicine, in the form of gel, orabase, solution, and mouthwash, were used. The experimental period of these trials ranged from 5 to 10 d [10,[17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…The heterogeneity was assessed subjectively by N. ) and p<0.001 [17]. All studies reported no adverse effects [10,[17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…In the studies included in this review, the treatment duration ranged from 5-10 d. [10,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Glucocorticoids, which have proven efficacy and safety, are often among the first choices for localized treatment. However, their long-term use may facilitate oral infection with Candida albicans, mucosal atrophy, susceptibility to infection, and gastrointestinal complication [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Efficacy and Safety of Herbal Medicine Therapy in Recurrent Aphthous Stomatitis: A Systematic Review

HASANAH

Hidayat

2021

Int J App Pharm

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Recurrent aphthous stomatitis is the most common oral mucous ulcerative lesion with challenging treatment. Herbal medicine therapy can propose clinical efficacy and safety due to its large biological activities. The objective was to review the clinical efficacy and safety of herbal medicine therapy in terms of ulcer size, pain score, healing duration, and adverse effects in recurrent aphthous stomatitis. A systematic was conducted based on the PRISMA statement. The search was performed using four electronic databases, namely PubMed, Cochrane, Science Direct, and Google Scholar for articles published from 2016 until 2021 using specific keywords. The search was limited to randomized controlled trials (RCTs), in English, full text, and study in humans. The main outcome is expected to be ulcer size, pain score, healing duration, and adverse effects. Quality assessment of selected articles was conducted using the Quality Appraisal of Randomized Trials Checklist (Cochrane Risk of Bias tool). The methodology quality of studies was evaluated using the Cochrane Handbook for Systematic Review of Interventions and Rev Man software. Five articles were eligible for analysis. The population of the sample study ranged from 34-70 patients of 15-65 y old. The herbs used were Aloe vera (Aloe barbadensis Miller), curcumin (Curcuma longa), licorice (Glycyrrhiza glabra), tobacco (Nicotiana tabacum L.), and pomegranate (Punica granatum Linn.). This review showed that there is some evidence of the clinical efficacy and safety of herbal medicine therapy in improved outcomes of recurrent aphthous stomatitis treatment with minimum adverse effects.

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Section: Resultsmentioning

confidence: 99%

“…The heterogeneity was assessed subjectively by N. ) and p<0.001 [17]. All studies reported no adverse effects [10,[17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…In the studies included in this review, the treatment duration ranged from 5-10 d. [10,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Efficacy and Safety of Herbal Medicine Therapy in Recurrent Aphthous Stomatitis: A Systematic Review

HASANAH

Hidayat

2021

Int J App Pharm

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“…Among the oleanane-type triterpenes, glycyrrhizin, under the form of licorice extract, an ancient remedy for gastro-duodenal ulcers, was investigated for its wound healing potential in recurrent aphthous stomatitis; a controlled randomized double blind clinical trial evaluated the effect of licorice mouthwash containing diphenhydramine, results indicating a significant reduction in the severity of pain and healing time [184]. Licorice extract and glycyrrhizin in combination with gentian root and willow bark extract were also studied for their implication in atopic dermatitis in a clinical trial that enrolled 10 patients; the general observation was a strong reduction of the inflammatory process in the affected area, comparable with 1% hydrocortisone acetate treatment [185].…”

Section: Clinical Trialsmentioning

confidence: 99%

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

et al. 2020

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Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.

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Natural Oral Care Products for the Treatment of Stomatitis

Kattimani,

Panga,

Gnanavel

et al. 2023

Pharmacological Studies in Natural Oral Care

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The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial

Cited by 17 publications

References 19 publications

Clinical Efficacy and Safety of Herbal Medicine Therapy in Recurrent Aphthous Stomatitis: A Systematic Review

Clinical Efficacy and Safety of Herbal Medicine Therapy in Recurrent Aphthous Stomatitis: A Systematic Review

Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches

Natural Oral Care Products for the Treatment of Stomatitis

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